Version 2.78

Part Descriptions

LP269367-1   CBA IFA
In cell binding assays or cell-based assays (CBA) also known as cell-based immunoassays, the DNA coding for a particular antigen is transfected into cultured cells, which are then used directly as substrate for antibody detection by immunofluorescence. The advantage of CBA IFA over conventional immunoassays is that purification and stability of the antigen is not required and they provide an in vivo substrate. Source: Regenstrief LOINC,

LP39188-5   Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome. PMID: 17706564 Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. [http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html] Source: Regenstrief LOINC

Fully-Specified Name

Component
Aquaporin 4 water channel Ab.IgG
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
CBA IFA

Additional Names

Short Name
AQP4 H2O channel IgG CSF Ql CBA IFA
Display Name
Aquaporin 4 water channel IgG Cell binding immunofluorescent assay Ql (CSF)
Consumer Name Alpha Get Info
Aquaporin 4 water channel IgG antibody, Spinal fluid

Example Answer List: LL2038-9

Source: Quest Diagnostics Inc.
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.65
Last Updated
Version 2.69
Change Reason
Release 2.67: COMPONENT: Updated "receptor" to "water channel" per current scientific nomenclature
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG50124-3 Aquaporin 4 water channel Ab.IgG|PrThr|Pt|CSF

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Receptor de Acuaporina 4 IgG:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:CBA IFA (inmunofluorescencia indirecta de estudio basqado en células)
es-MX Spanish (Mexico) Acuaporina 4 canal de agua Ab.IgG:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Ensayo inmunofluorescente de unión a células
fr-FR French (France) Aquaporine 4 récepteur anticorps IgG:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Immunofluorescence CBA
it-IT Italian (Italy) Acquaporina 4, canale idrico Ab.IgG:PrThr:Pt:LCS:Ord:CBA IFA
Synonyms: anticorpi IgG anticorpo Canale idrico dell''acquaporina 4 Fluorescenza indiretta degli anticorpi (IFA) Liquido cerebrospinale Presenza o Soglia Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant
zh-CN Chinese (China) 水通道蛋白 4 受体 抗体.IgG:存在情况或阈值:时间点:脑脊液:序数型:CBA IFA
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 Devic 氏综合征 IgG Devic 综合征 IgG Devic氏综合征 Ab.IgG Devic氏综合征抗体.IgG Devic综合征 Ab.IgG Devic综合征抗体.IgG H2O NMO Ab.IgG NMO 抗体.IgG 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 G 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 细胞结合分析免疫荧光法;CBA IFA 法 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 视神经脊髓炎 Ab.IgG 视神经脊髓炎 IgG 间接荧光抗体 间接荧光抗体试验

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=90818-6