Version 2.80

Term Description

This term represents a ratio (allelic ratio), following PCR amplification, of a patient's FLT3 gene DNA having internal tandem duplication to that same patient's wild type FLT3 gene DNA not having such duplication. The result is expressed as a signal ratio of peak band intensities and correlates to cells with and without mutated DNA. A ratio of 100.00 is the maximum and indicates a patient specimen has 100% FLT3-mutated tumor with no healthy cells. A ratio between 0.03 and 0.05 indicates low levels of disease.

Part Descriptions

LP200463-0   FLT3 gene internal tandem
The FLT3 gene (fms-related tyrosine kinase 3) [HGNC Gene ID:3765] is located on chromosome 13q12. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] [NCBI Gene ID:2322] FLT3 mutations occur in approximately 1/3 of patients with AML. About 70% are internal tandem duplications, and the rest are due to variants in the tyrosine kinase domain of FLT3, primarily at Asp835 (D835). PMID: 17124058 Source: Regenstrief LOINC

LP228449-7   FLT3 gene internal tandem duplication
The FLT3 gene (fms-related tyrosine kinase 3) [HGNC Gene ID:3765] is located on chromosome 13q12. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] [NCBI Gene ID:2322] FLT3 mutations occur in approximately 1/3 of patients with AML. About 70% are internal tandem duplications, and the rest are due to variants in the tyrosine kinase domain of FLT3, primarily at Asp835 (D835). PMID: 17124058 Source: Regenstrief LOINC

Fully-Specified Name

Component
FLT3 gene internal tandem duplication/normal
Property
Ratio
Time
Pt
System
Bld/Tiss
Scale
Qn
Method
Molgen

Additional Names

Long Common Name
FLT3 gene internal tandem duplication/Normal [Ratio] in Blood or Tissue by Molecular genetics method
Short Name
FLT3 ITD Dp/Nor Bld/T-Rto
Display Name
FLT3 gene internal tandem dup/Normal Molgen (Bld/Tiss) [Ratio]
Consumer Name Alpha Get Info
FLT3 gene internal tandem/Normal, Blood or tissue specimen

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.66
Last Updated
Version 2.71 (MIN)
Change Reason
Release 2.71: DefinitionDescription: Updated to add additional information;
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Εσωτερικός διαδοχικός διπλασιασμός γονιδίου FLT3 διπλασιασμός/Φυσιολογικό:Ratio:Pt:Αίμα/Ιστός:Qn:Μοριακή γενετική
Synonyms: Ratio Γονίδιο Γονίδιο FLT3 Εσωτερικός διαδοχικός διπλασιασμός γονιδίου FLT3
es-ES Spanish (Spain) Gen FLT3 duplicación interna en tandem Duplicación/Normal:Fracción:Punto temporal:Sangre o tejido:Qn:Genética molecular
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Duplicación interna en tándem del gen FLT3 / normal:Proporción:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-FR French (France) FLT3 gène duplication ITD/gène normal:Ratio:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
it-IT Italian (Italy) Doppio gene interno FLT3, duplicazione/Normale:Rapporto:Pt:Sangue/Tess:Qn:Molgen
Synonyms: Gene FLT3 Genetica molecolare Mutazione genica Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) FLT3-gen interne tandem duplicatie/normaal:verhouding:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek
Synonyms: FLT3 gen FLT3 gen interne tandem molgen
tr-TR Turkish (Turkey) FLT3 geni internal tandem dublikasyon/Normal:Oran:Zmlı:Kan/Dk:Kant:Molgen
zh-CN Chinese (China) FLT3 基因内部串联 复制/正常:比率:时间点:全血/组织:定量型:分子遗传学类实验室方法
Synonyms: FL 细胞因子受体前体;FLK2;fms-相关性酪氨酸激酶 3;STK1;STK-1;干细胞酪氨酸激酶 1 FLT3 基因内部串联重复;FLT3 基因内部串联重复突变;FLT3 gene internal tandem duplication;内部串联重复突变;内部串联重复;内部串联突变;internal tandem duplications;ITD 全血或组织;血液/组织;血液或组织 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 基因复制;基因重复;重复 对照 对照标准 对照物 对照的 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 来自于不同体系的两个观察指标之比;比;比值 正常的 血;血液 遗传基因;遗传因子;吉恩;生物基因

Example Units

Unit Source
{ratio} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=92844-0