Version 2.77

85477-8 Influenza virus A RNA [Presence] in Upper respiratory specimen by NAA with probe detection

Part Descriptions

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. PMID: 20542248 ] PMID: 25812763
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A RNA
Property
PrThr
Time
Pt
System
Respiratory system specimen.upper
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
FLUAV RNA Upper resp Ql NAA+probe
Display Name
FLUAV RNA NAA+probe Ql (Upper resp)
Consumer Name Alpha Get Info
Influenza A (Flu A), Upper respiratory

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.77
Change Reason
Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC;
Order vs. Observation
Both

Example Answer List LL2021-5

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Invalid Copyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value) LA15841-2

Member of these Panels

LOINC Long Common Name
85476-0 Influenza virus A and B and Respiratory syncytial virus RNA panel - Upper respiratory specimen by NAA with probe detection
92882-0 Influenza virus types A and B panel - Upper respiratory specimen by NAA with probe detection

Member of these Groups Get Info

LOINC Group Group Name
LG32757-3 Influenza virus
LG34064-2 Influenza virus A RNA|PrThr|Sys:ANYResp

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Influenza-Virus A RNA:Nachweis oder Schwellenwert:Zeitpunkt:Probenmaterial vom oberen Respirationstrakt:Ordinal:Zielfragmentamplifikation mit Sondendetektion
es-MX Spanish (Mexico) ARN del virus de la influenza A:Presencia o umbral:Punto temporal:Muestra respiratoria superior:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Influenza virus A ARN:Présence/Seuil:Ponctuel:Voies respiratoires supérieures:Qualitatif:PCR amplification de cible
nl-NL Dutch (Netherlands) Influenzavirus A RNA:aanwezigheid:moment:bovenste luchtwegen:ordinaal:probe-detectie
Synonyms: bovenste ademhalingsstelsel; systema respiratorium superior probe.amp.tar systema respiratorium; ademhalingsstelsel

85478-6 Influenza virus B RNA [Presence] in Upper respiratory specimen by NAA with probe detection

Part Descriptions

LP14240-3   Influenza virus B
Influenza virus from the family Orthomyxoviridae are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C viruses are medically relevant to humans. Influenza A and B viruses have a similar structure whereby these viruses each contain eight discrete single-stranded RNA gene segments, each encoding at least one protein. While having a close phylogenetic relationship, influenza virus types A and B manifest very differently. While IAV infects birds, humans and other mammals, influenza B only infects humans and seals. Although both viruses cause human respiratory infection seasonally in temperate climate regions and more continually in the tropics, influenza B is normally less prevalent and causes less severe disease than IAV viruses. Research is ongoing to determine the evolutionary and epidemiological factors that shape the genetic diversity of influenza B virus. PMID: 25812763 [CDC:flu/about/viruses/types] Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus B RNA
Property
PrThr
Time
Pt
System
Respiratory system specimen.upper
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
FLUBV RNA Upper resp Ql NAA+probe
Display Name
FLUBV RNA NAA+probe Ql (Upper resp)
Consumer Name Alpha Get Info
Influenza B (Flu B), Upper respiratory

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.77
Change Reason
Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC;
Order vs. Observation
Both

Example Answer List LL2021-5

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Invalid Copyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value) LA15841-2

Member of these Panels

LOINC Long Common Name
85476-0 Influenza virus A and B and Respiratory syncytial virus RNA panel - Upper respiratory specimen by NAA with probe detection
92882-0 Influenza virus types A and B panel - Upper respiratory specimen by NAA with probe detection

Member of these Groups Get Info

LOINC Group Group Name
LG32757-3 Influenza virus
LG34065-9 Influenza virus B RNA|PrThr|Sys:ANYResp

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Influenza-Virus B RNA:Nachweis oder Schwellenwert:Zeitpunkt:Probenmaterial vom oberen Respirationstrakt:Ordinal:Zielfragmentamplifikation mit Sondendetektion
es-MX Spanish (Mexico) ARN del virus de la influenza B:Presencia o umbral:Punto temporal:Muestra respiratoria superior:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Influenza virus B ARN:Présence/Seuil:Ponctuel:Voies respiratoires supérieures:Qualitatif:PCR amplification de cible
nl-NL Dutch (Netherlands) Influenzavirus B RNA:aanwezigheid:moment:bovenste luchtwegen:ordinaal:probe-detectie
Synonyms: bovenste ademhalingsstelsel; systema respiratorium superior probe.amp.tar systema respiratorium; ademhalingsstelsel