Version 2.78

Part Descriptions

LP411023-7   HTR2A gene.c.614-2211T>C
The rs7997012 (c.614-2211T>C) variant is located in intron 2 of the HTR2A gene and codes for the 5-HT2A serotonin receptor. The variant has been identified as a marker of citalopram response. Patients with depression who are genotype AA are associated with increased likelihood of response when treated with citalopram as compared to genotype GG.[NCBI ClinVar ID: RCV000211197][OMIM: 182135#0003] Source: Regenstrief LOINC

LP40502-4   HTR2A gene
The HTR2A gene is located on chromosome 13 at position q14-q21 and encodes one of the receptors for serotonin, a neurotransmitter with many roles.[HGNC Gene ID:5293] Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] [NCBI Gene ID: 3356] Source: National Center for Biotechnology Information (NCBI) Gene, HTR2A gene

Fully-Specified Name

Component
HTR2A gene.c.614-2211T>C
Property
Geno
Time
Pt
System
Bld/Tiss
Scale
Nom
Method
Molgen

Additional Names

Short Name
HTR2A c.614-2211T>C Geno Bld/T
Display Name
HTR2A gene c.614-2211T>C genotype Molgen (Bld/Tiss)
Consumer Name Alpha Get Info
HTR2A gene c.614-2211T>C genotype, Blood or tissue specimen

Example Answer List: LL3030-5

Source: Regenstrief LOINC
Answer Code Score Answer ID
T/T (wild type) LA21504-8
T/C (heterozygous) LA21505-5
C/C (homozygous) LA21506-3

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.68
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen HTR2A c.614-2211T> C:Genotipo:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MX Spanish (Mexico) Gen HTR2A c.614-2211T> C:Genotipo:Punto temporal:Sangre o tejido:Nominal:Genética molecular
fr-FR French (France) HTR2A gène mutation c.614-2211T>C:Génotype:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) HTR2A, gene.c.614-2211T>C:Geno:Pt:Sangue/Tess:Nom:Molgen
Synonyms: Farmacogenomica Gene HTR2A c.614-2211T>C Genetica molecolare Genotipo Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
zh-CN Chinese (China) HTR2A 基因.c.614-2211T>C:基因型:时间点:全血/组织:名义型:分子遗传学类实验室方法
Synonyms: 5-HT-2A 5-羟基色胺受体 2A 基因 5-羟色胺受体 2A 基因 5-羟色胺受体 2A 基因（5-hydroxytryptamine receptor 2A gene，5-HT-2A） C 型;丙;丙型 五羟色胺受体 2A 基因 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 血清素受体 2A 基因 血清素受体 2A 基因（serotonin receptor 2A gene） 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93190-7