Version 2.74

Part Description

LP14372-4   Coproporphyrin 3
Coproporhyrin III is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin III is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. [PMID: 3327428] Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Corproporphyrin III

Fully-Specified Name

Coproporphyrin 3

Additional Names

Short Name
Copro3 Ur-mCnc
Display Name
Coproporphyrin 3 (U) [Mass/Vol]
Consumer Name Alpha
Coproporphyrin 3, Urine

Basic Attributes

First Released
Version 1.0i
Last Updated
Version 2.73
Order vs. Observation
Common Test Rank

Member of these Groups Get Info

LOINC Group Group Name
LG36352-9 Coproporphyrin 3|MCnc|Urine
LG45546-5 Coproporphyrin 3|Pt|Urine

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 粪卟啉 III:质量浓度:时间点:尿液:定量型:
Synonyms: Ⅲ Copro;Coproporph;四羧基卟啉 Copro3;粪卟啉 3;粪卟啉Ⅲ III 三 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 叁 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积)
es-AR Spanish (Argentina) coproporfirina 3:concentración de masa:punto en el tiempo:orina:cuantitativo:
fr-CA French (Canada) Coproporphyrine 3:Concentration de masse:Temps ponctuel:Urine:Quantitatif:
et-EE Estonian (Estonia) Koproporfüriin 3:MCnc:Pt:U:Qn:
Synonyms: Juhuslik Kvantitatiivne Uriin
pt-BR Portuguese (Brazil) Coproporfirina 3:MCnc:Pt:Urina:Qn:
Synonyms: ; Copro3; Coproporphyrin III; Coproporphyrins; Copro; Tetracarboxyporphyrin; Coproporph; Tetracarboxyl porphyrin; Tetracarboxylporphyrin; Tetracarboxylporphyrins; Mass concentration; Level; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry
es-ES Spanish (Spain) Coproporfirina 3:Concentración de masa:Punto temporal:Orina:Qn:
ko-KR Korean (Korea, Republic Of) 코프로포르피린 3:질량농도:검사시점:뇨:정량:
it-IT Italian (Italy) Coproporfirina 3:MCnc:Pt:Urine:Qn:
Synonyms: Chimica Concentrazione di Massa Punto nel tempo (episodio)
fr-FR French (France) Coproporphyrine 3:Masse/Volume:Ponctuel:Urine:Numérique:
tr-TR Turkish (Turkey) Koproporfirin 3:KütlKons:Zmlı:İdrar:Kant:
ru-RU Russian (Russian Federation) Копропорфирин 3:МассКонц:ТчкВрм:Моча:Колич:
Synonyms: Количественный Массовая концентрация Точка во времени;Момент
nl-NL Dutch (Netherlands) coproporfyrine 3:massa/volume:moment:urine:kwantitatief:
fr-BE French (Belgium) Coproporphyrine 3:Concentration de masse:Temps ponctuel:Urine:Quantitatif:
es-MX Spanish (Mexico) Coproporfirina 3:Concentración de masa:Punto temporal:Orina:Cuantitativo:

Example Units

Unit Source
ng/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

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