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Part Description

LP14372-4   Coproporphyrin 3
Coproporhyrin III is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin III is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Corproporphyrin III

LOINC Names Get Info

Fully-Specified Name
Coproporphyrin 3:MCnc:Pt:Urine:Qn:
Long Common Name
Coproporphyrin 3 [Mass/volume] in Urine
Short Name
Copro3 Ur-mCnc
Display Name
Coproporphyrin 3 (U) [Mass/Vol]
Consumer Name Alpha Get Info
Coproporphyrin 3, Urine

Part Model Get Info

  • Component
    Coproporphyrin 3
    LP14372-4
    • Analyte
      Coproporphyrin 3
      LP14372-4
      • Component Numerator
        Coproporphyrin 3
        LP14372-4
        • Component Numerator Core
          Coproporphyrin 3
          LP14372-4
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    MCnc
    LP6827-2
  • Time
    Pt
    LP6960-1
  • System
    Urine
    LP7681-2
    • System Core
      Urine
      LP7681-2
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 1.0i
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Observation
Common Test Rank Get Info
9195

Member of these Groups Get Info

LOINC GroupGroup Name
LG36352-9Coproporphyrin 3|MCnc|Urine
LG45546-5Coproporphyrin 3|Pt|Urine

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Koproporfyrin 3:Hmotnostní koncentrace:Časový bod:Moč:Kvantitativní:
de-ATGerman (Austria)Synonyms: Koproporphyrin III /U
el-GRGreek (Greece)Κοπροπορφυρίνη 3:MCnc:Pt:Ούρα:Qn:
Synonyms: CHEM MCnc Pt Qn Κοπροπορφυρίνη Κοπροπορφυρίνη 3 Ούρα
es-ARSpanish (Argentina)coproporfirina 3:concentración de masa:punto en el tiempo:orina:cuantitativo:
es-ESSpanish (Spain)Coproporfirina 3:Concentración de masa:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Coproporfirina 3:Concentración de masa:Punto temporal:Orina:Cuantitativo:
et-EEEstonian (Estonia)Koproporfüriin 3:MCnc:Pt:U:Qn:
Synonyms: Juhuslik Kvantitatiivne Uriin
fr-CAFrench (Canada)Coproporphyrine 3:Concentration de masse:Temps ponctuel:Urine:Quantitatif:
fr-FRFrench (France)Coproporphyrine 3:Masse/Volume:Ponctuel:Urine:Numérique:
fr-BEFrench (Belgium)Coproporphyrine 3:Concentration de masse:Temps ponctuel:Urine:Quantitatif:
it-ITItalian (Italy)Coproporfirina 3:MCnc:Pt:Urine:Qn:
Synonyms: Chimica Concentrazione di Massa Punto nel tempo (episodio)
ko-KRKorean (Korea, Republic Of)코프로포르피린 3:질량농도:검사시점:뇨:정량:
nl-NLDutch (Netherlands)coproporfyrine 3:massa/volume:moment:urine:kwantitatief:
pt-BRPortuguese (Brazil)Coproporfirina 3:MCnc:Pt:Urina:Qn:
Synonyms: ; Copro3; Coproporphyrin III; Coproporphyrins; Copro; Tetracarboxyporphyrin; Coproporph; Tetracarboxyl porphyrin; Tetracarboxylporphyrin; Tetracarboxylporphyrins; Mass concentration; Level; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry
ru-RURussian (Russian Federation)Копропорфирин 3:МассКонц:ТчкВрм:Моча:Колич:
Synonyms: Количественный Массовая концентрация Точка во времени;Момент
tr-TRTurkish (Turkey)Koproporfirin 3:KütlKons:Zmlı:İdrar:Kant:
zh-CNChinese (China)粪卟啉 III:质量浓度:时间点:尿液:定量型:
Synonyms: Ⅲ Copro;Coproporph;四羧基卟啉 Copro3;粪卟啉 3;粪卟啉Ⅲ III 三 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 叁 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积)

Example Units

UnitSource
ng/mLExample UCUM Units
ng/mLREGENSTRIEF

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=9345-0