94359-7

Glutamate decarboxylase 65 IgG+IgM Ab [Moles/volume] in Cerebrospinal Fluid by Immunoassay

Active

Part Description

LP18489-2 Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. PMID: 7532143 GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years. PMID: 11114103 GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located. PMID: 22412264 Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases. PMID: 22405456 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Glutamate decarboxylase 65 Ab.IgG+IgM:SCnc:Pt:CSF:Qn:IA
Long Common Name: Glutamate decarboxylase 65 IgG+IgM Ab [Moles/volume] in Cerebrospinal Fluid by Immunoassay
Short Name: GAD65 IgG+IgM CSF IA-sCnc
Display Name: Glutamate decarboxylase 65 IgG+IgM IA (CSF) [Moles/Vol]
Consumer Name Alpha Get Info: Glutamate decarboxylase 65 IgG+IgM, Spinal fluid

Part Model Get Info

Component
Glutamate decarboxylase 65 Ab.IgG+IgM
LP417806-9
- Analyte
  Glutamate decarboxylase 65 Ab.IgG+IgM
  LP417806-9
  - Component Numerator
    Glutamate decarboxylase 65 Ab.IgG+IgM
    LP417806-9
    - Component Numerator Core
      Glutamate decarboxylase 65
      LP18489-2
    - Component Numerator Core Suffix
      Ab.IgG+IgM
      LP32404-3
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
SCnc
LP6860-3
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
CSF
LP7156-5
- System Core
  CSF
  LP7156-5
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IA
LP217197-5

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.68
Last Updated: Version 2.83 (MIN)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
94707-7	Dementia autoimmune Ab panel - Cerebrospinal Fluid
94708-5	Encephalopathy autoimmune Ab panel - Cerebrospinal Fluid
94709-3	Epilepsy autoimmune Ab panel - Cerebrospinal Fluid
94712-7	Movement disorder autoimmune Ab panel - Cerebrospinal Fluid
94353-0	Myelopathy autoimmune Ab panel - Cerebrospinal Fluid
101416-6	Pediatric autoimmune central nervous system disorders evaluation panel - Cerebrospinal Fluid

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Glutamátdekarboxyláza 65 IgG+IgM:Látková koncentrace:Časový bod:Mozkomíšní mok:Kvantitativní:Imunoanalýza
el-GR	Greek (Greece)	Γλουταμινική αποκαρβοξυλάση 65 Αντισώματα IgG+IgM:SCnc:Pt:ΕΝΥ:Qn:IA Synonyms: IA Pt Qn SCnc SERO Ανοσοσφαιρίνη G Ανοσοσφαιρίνη M Αντίσωμα Αντισώματα IgG Αντισώματα IgG & IgM Αντισώματα IgG+IgM Γλουταμινική αποκαρβοξυλάση Γλουταμινική αποκαρβοξυλάση 65 Γλουταμινικό οξύ ΕΝΥ
es-ES	Spanish (Spain)	Glutamato decarboxilasa 65 IgG+IgM:Concentración de sustancia:Punto temporal:Líquido Cefalorraquideo:Qn:IA Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Glutamato descarboxilasa 65 IgG + IgM:Concentración de sustancias:Punto temporal:Fluído espinal cerebral:Cuantitativo:Inmunoensayo
et-EE	Estonian (Estonia)	Glutamaadi dekarboksülaasi 65 vastased antikehad.IgG+IgM:SCnc:Pt:CSF:Qn:IA Synonyms: Aine kontsentratsioon Immuunglobuliin G Immuunglobuliin M Juhuslik Kvantitatiivne Liikvor
fr-FR	French (France)	Glutamate décarboxylase 65 Ac IgG+IgM:Moles/Volume:Ponctuel:Liquide céphalorachidien:Numérique:Immunoanalyse
fr-BE	French (Belgium)	Glutamate décarboxylase 65 Anticorps.IgG+IgM:Concentration de substance:Temps ponctuel:LCR:Quantitatif:IA Synonyms: Anticorps
fr-CA	French (Canada)	Glutamate décarboxylase 65, IgG+IgM:Concentration de substance:Temps ponctuel:LCR:Quantitatif:IA
it-IT	Italian (Italy)	Glutammato decarbossilasi 65 Ab.IgG+IgM:SCnc:Pt:LCS:Qn:IA Synonyms: anticorpi IgG anticorpi IgG e IgM Anticorpi IgG+IgM anticorpo Concentrazione di Sostanza GAD65 Immunoassay Liquido cerebrospinale Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	glutamaatdecarboxylase 65 As.IgG + IgM:mol/volume:moment:liquor cerebrospinalis:kwantitatief:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	Dekarboksylaza glutaminianu 65 Ab.IgG+IgM:stężenie molowe:punkt w czasie:płyn mózgowo-rdzeniowy:ilościowy:metoda immunologiczna Synonyms: Dekarboksylaza kwasu glutaminowego o masie 65 kDa;GAD 65 kDa Dekarboksylaza kwasu glutaminowego;GAD IgG IgM Przeciwciała do dekarboksylazy glutaminianowej 65 przeciwciała IgG Przeciwciała IgG do dehydrogenazy glutaminianowej 65 przeciwciała IgG i IgM Przeciwciała IgG i IgM do dekarboksylazy glutaminianowej 65
ru-RU	Russian (Russian Federation)	Глутаматдекарбоксилаза 65 Ат.IgG+IgM:МолКонц:ТчкВрм:ЦСЖ:Колич:IA Synonyms: Антитело Количественный Молярность;Молярная объёмная концентрация Точка во времени;Момент Цереброспинальная жидкость
tr-TR	Turkish (Turkey)	Glutamat dekarboksilaz 65 Ab.IgG+IgM:SubKons:Zmlı:BOS:Kant:İA Synonyms: Ak Ak.IgG Ak.IgG+IgM İmmünölçüm, immünoassay
zh-CN	Chinese (China)	谷氨酸脱羧酶-65 抗体.IgG+IgM:物质的量浓度:时间点:脑脊液:定量型:免疫测定法 Synonyms: Ab.IgG;IgG;抗体 IgG Ab.IgG+IgM;IgG+IgM;抗体 IgG+抗体 IgM Ab;自身抗体 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 GAD65;GAD-65;谷氨酸脱羧酶 65;谷氨酸脱羧酶 65（Glutamate Decarboxylase 65，GAD65，Glutamic acid decarboxylase-65，GAD-65） GADA Glu 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验免疫球蛋白 G 免疫球蛋白 M 可用数量表示的;定量性;数值型;数量型;连续数值型标尺抗体.IgG & IgM;抗体.IgG+IgM 时刻;随机;随意;瞬间脊液脊髓液脑脊液（Cerebral spinal fluid，CSF）脑脊髓液血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类谷氨酸脱羧酶 65 Ab 谷氨酸脱羧酶 65 抗体谷氨酸脱羧酶-65 Ab 麸胺酸去羧酶;麸胺酸去羧基酶;麸氨酸去羧基酶;GAD

Example Units

Unit	Source
nmol/L	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.