94446-2
HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC)
Active
48767-8 Annotation comment [Interpretation] Narrative
Term Description
This is an observation code indicating that a particular observation represents a free text annotation comment that can be appended to some other observation such as a lab result.
Source: Regenstrief LOINC
Observation Required in Panel
Optional
Type of Entry
Question expects user entry - requires response [Q]
Fully-Specified Name
- Component
- Annotation comment
- Property
- Imp
- Time
- Pt
- System
- {system}
- Scale
- Nar
- Method
Additional Names
- Short Name
- Annotation comment Imp
Basic Attributes
- Class
- DOC.MISC
- Type
- Clinical
- First Released
- Version 2.21
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 690
Member of these Panels
LOINC | Long Common Name |
---|---|
48769-4 | Continuity of Care panel |
55168-9 | Data Elements for Emergency Department Systems (DEEDS) Release 1.1 |
102116-1 | ESR1 gene mutation panel - Tissue by Molecular genetics method |
102117-9 | Gastrointestinal stromal tumor multigene mutation panel - Tissue by Molecular genetics method |
86535-2 | Healthcare associated infection report - recommended CDA R3 set |
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
94440-5 | HLA-DP and DQ and DR (class II) IgG panel - Serum or Plasma by Flow cytometry (FC) |
101400-0 | Metanephrine, Normetanephrine, 3-Methoxytyramine panel - 24 hour Urine |
93321-8 | PT mixing study panel - Platelet poor plasma by Coagulation assay |
98412-0 | Retrograde ejaculation evaluation panel - Urine |
102118-7 | Rhabdomyolysis and Metabolic myopathy multigene panel - Blood or Tissue by Molecular genetics method |
102119-5 | Skeletal muscle channelopathy multigene panel - Blood or Tissue by Molecular genetics method |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-MX | Spanish (Mexico) | Comentario de anotación: |
fr-FR | French (France) | Commentaire: |
fr-CA | French (Canada) | Annotation commentaire: |
fr-BE | French (Belgium) | Annotation commentaire: |
it-IT | Italian (Italy) | Annotazioni e commenti: Synonyms: Documentazione miscellanea Impressione/interpretazione di studio Miscellanea Punto nel tempo (episodio) |
nl-NL | Dutch (Netherlands) | verklarend commentaar: |
ru-RU | Russian (Russian Federation) | Аннотация комментарий: Synonyms: Впечатление/интерпретация исследования Описательный Поясняющий комментарий Точка во времени; |
zh-CN | Chinese (China) | 注释: Synonyms: {体系} 印象是一种诊断陈述, |
94441-3 HLA-A and B and C (class I) IgG Ab [Identifier] in Serum or Plasma by Flow cytometry (FC)
Part Descriptions
LP190813-8 HLA-A & B & C (class I)
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.
Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- HLA-A & B & C (class I) Ab.IgG
- Property
- Prid
- Time
- Pt
- System
- Ser/Plas
- Scale
- Nom
- Method
- Flow cytometry
Additional Names
- Short Name
- HLA-A+B+C (class I) IgG SerPl FC
- Display Name
- HLA-A and B and C (class I) IgG FC Nom
- Consumer Name Alpha Get Info
- HLA-A and B and C (class I) IgG antibody, Blood
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Observation
Example Answer List LL5520-3
Answer | Code | Score | Answer ID |
---|---|---|---|
Anti-A1 | LA23858-6 | ||
Anti-A2 | LA23859-4 | ||
Anti-A3 | LA23860-2 | ||
Anti-A9 | LA23861-0 | ||
Anti-A11 | LA23863-6 | ||
Anti-A28 | LA23864-4 | ||
Anti-A29 | LA23865-1 | ||
Anti-B7 | LA23870-1 | ||
Anti-B12 | LA23872-7 | ||
Anti-B13 | LA23873-5 | ||
Anti-B22 | LA23876-8 | ||
Anti-B27 | LA23877-6 | ||
Anti-B35 | LA23878-4 | ||
Anti-B41 | LA23880-0 | ||
Anti-Cw1 | LA23886-7 | ||
Anti-Cw4 | LA23888-3 | ||
Anti-Cw5 | LA23889-1 | ||
Anti-Cw3 | LA23890-9 | ||
Anti-Cw7 | LA23892-5 |
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-A, B, C (clase I) IgG: |
es-MX | Spanish (Mexico) | HLA-A y B y C (clase I) Ab.IgG: |
fr-FR | French (France) | HLA-A et B et C (classe I) anticorps IgG: |
it-IT | Italian (Italy) | HLA-A & B & C (classe I) Ab.IgG: Synonyms: anticorpi IgG anticorpo Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi HLA-A e B e C (classe I) Plasma Presenza o Identità Punto nel tempo (episodio) Siero Siero o Plasma |
nl-NL | Dutch (Netherlands) | HLA A & B & C (klasse I) As.IgG: Synonyms: antistof; |
zh-CN | Chinese (China) | HLA-A 与 B 与 C (I 类) 抗体.IgG: Synonyms: A 型 A,B 型; |
94442-1 HLA-A and B and C (class I) IgG with prozone effect [Identifier] in Serum or Plasma by Flow cytometry (FC)
Term Description
Sometimes high titer antibody can be associated with low levels of detection (low mean fluorescence intensity, MFI, for the Luminex HLA bead assay), a phenomenon often referred to as the "prozone" effect. This term is intended to report those antibodies that were not detected with original sample, but became detectable after dilution or assay treatment. Some laboratories refer to these "prozone antigens observed", meaning those antigens for which the patient's antibody exhibited prozone effect.
Source: Regenstrief LOINC
Part Descriptions
LP417651-9 HLA-A & B & C (class I) Ab.IgG with prozone effect
HLA antibodies showing the prozone effect represent antibody specificities against HLA antigens that were not apparent in undiluted patient specimen, but became apparent after dilution. This so called prozone effect has been attributed to a number of putative mechanisms, including complement factor, antibody agglutination or competing IgM. Prozone effect can often be reversed with serum dilution or treatment with heat, EDTA, or DTT.
Source: Regenstrief LOINC
LP417651-9 HLA-A & B & C (class I) Ab.IgG with prozone effect
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.
Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- HLA-A & B & C (class I) Ab.IgG with prozone effect
- Property
- Prid
- Time
- Pt
- System
- Ser/Plas
- Scale
- Nom
- Method
- Flow cytometry
Additional Names
- Short Name
- HLA class I Ab.IgG prozone SerPl FC
- Display Name
- HLA-A & B & C (class I) Ab.IgG with prozone effect FC Nom
- Consumer Name Alpha Get Info
- HLA-A & B & C (class I) Ab.IgG with prozone effect, Blood
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Observation
Example Answer List LL5520-3
Answer | Code | Score | Answer ID |
---|---|---|---|
Anti-A1 | LA23858-6 | ||
Anti-A2 | LA23859-4 | ||
Anti-A3 | LA23860-2 | ||
Anti-A9 | LA23861-0 | ||
Anti-A11 | LA23863-6 | ||
Anti-A28 | LA23864-4 | ||
Anti-A29 | LA23865-1 | ||
Anti-B7 | LA23870-1 | ||
Anti-B12 | LA23872-7 | ||
Anti-B13 | LA23873-5 | ||
Anti-B22 | LA23876-8 | ||
Anti-B27 | LA23877-6 | ||
Anti-B35 | LA23878-4 | ||
Anti-B41 | LA23880-0 | ||
Anti-Cw1 | LA23886-7 | ||
Anti-Cw4 | LA23888-3 | ||
Anti-Cw5 | LA23889-1 | ||
Anti-Cw3 | LA23890-9 | ||
Anti-Cw7 | LA23892-5 |
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-A, B, C (clase I) con efecto prozona por Ac IgG: |
es-MX | Spanish (Mexico) | HLA-A & B & C (clase I) Ab.IgG con efecto prozona: |
fr-FR | French (France) | HLA-A et B et C (classe I) anticorps IgG avec effet prozone: |
it-IT | Italian (Italy) | HLA-A & B & C (classe I) Ab.IgG con effetto prozona: Synonyms: Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi HLA-A e B e C (classe I) HLA-Ae B e C (classe I) Ab.IgG con effetto prozona Plasma Presenza o Identità Punto nel tempo (episodio) Siero Siero o Plasma |
nl-NL | Dutch (Netherlands) | HLA A & B & C (klasse I) As.IgG met prozoneffect: |
pl-PL | Polish (Poland) | HLA-A & B & C (klasa I) Ab.IgG z efektem prozony: Synonyms: IgG Przeciwciała do antygenu I układu grupowego krwi Ii Przeciwciała IgG do HLA-A, B i C (klasa I) Przeciwciała IgG do HLA-A, B i C (klasa I) ze efektem prozony |
zh-CN | Chinese (China) | HLA-A 与 B 与 C (I 类) 抗体.IgG 伴前带效应: Synonyms: A 型 A,B 型; |
94430-6 HLA-A and B and C (class I) IgG low risk [Identifier] in Serum or Plasma by Flow cytometry (FC)
Term Description
Laboratories that perform HLA antibody testing often report the specific antibodies found in categories based on the "amount" of each antibody found (called mean fluorescent intensity, MFI, for the common Luminex bead method). Theoretically, the antibodies present in higher concentrations, which are more likely to react with donor antigens, will have higher MFI values. Since risk stratification based on MFI range is not standardized and the exact cutoffs vary from lab to lab, this term is intended to report those HLA antibodies found in the lower risk stratification of MFI values, but still detectable and possibly having a risk of rejection (For one lab this range was 500 < MFI < 1999).
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- HLA-A & B & C (class I) Ab.IgG low risk
- Property
- Prid
- Time
- Pt
- System
- Ser/Plas
- Scale
- Nom
- Method
- Flow cytometry
Additional Names
- Short Name
- HLA class I Ab.IgG low risk SerPl FC
- Display Name
- HLA-A & B & C (class I) Ab.IgG low risk FC Nom
- Consumer Name Alpha Get Info
- HLA-A & B & C (class I) Ab.IgG low risk, Blood
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Observation
Example Answer List LL5520-3
Answer | Code | Score | Answer ID |
---|---|---|---|
Anti-A1 | LA23858-6 | ||
Anti-A2 | LA23859-4 | ||
Anti-A3 | LA23860-2 | ||
Anti-A9 | LA23861-0 | ||
Anti-A11 | LA23863-6 | ||
Anti-A28 | LA23864-4 | ||
Anti-A29 | LA23865-1 | ||
Anti-B7 | LA23870-1 | ||
Anti-B12 | LA23872-7 | ||
Anti-B13 | LA23873-5 | ||
Anti-B22 | LA23876-8 | ||
Anti-B27 | LA23877-6 | ||
Anti-B35 | LA23878-4 | ||
Anti-B41 | LA23880-0 | ||
Anti-Cw1 | LA23886-7 | ||
Anti-Cw4 | LA23888-3 | ||
Anti-Cw5 | LA23889-1 | ||
Anti-Cw3 | LA23890-9 | ||
Anti-Cw7 | LA23892-5 |
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-A, B, C (class I) bajo riesgo por Ac IgG: |
es-MX | Spanish (Mexico) | HLA-A & B & C (clase I) Ab.IgG bajo riesgo: |
fr-FR | French (France) | HLA-A et B et C (classe I) anticorps IgG MFI faible: |
it-IT | Italian (Italy) | HLA-A & B & C (classe I) Ab.IgG, rischio basso: Synonyms: Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi HLA-A e B e C (classe I) Plasma Presenza o Identità Punto nel tempo (episodio) Rischio basso di HLA-A & |
nl-NL | Dutch (Netherlands) | HLA A & B & C (klasse I) As.IgG laag risico: |
pl-PL | Polish (Poland) | HLA-A & B & C (klasa I) Ab.IgG niskiego ryzyka: Synonyms: IgG Przeciwciała do antygenu I układu grupowego krwi Ii Przeciwciała IgG do HLA-A, B i C (klasa I) Przeciwciała IgG do HLA-A, B i C (klasa I) niskiego ryzyka |
zh-CN | Chinese (China) | HLA-A 与 B 与 C (I 类) 抗体.IgG 低度风险: Synonyms: A 型 A,B 型; |
94450-4 HLA-A and B and C (class I) IgG intermediate risk [Identifier] in Serum or Plasma by Flow cytometry (FC)
Term Description
Laboratories that perform HLA antibody testing often report the specific antibodies found in categories based on the "amount" of each antibody found (called mean fluorescent intensity, MFI, for the common Luminex bead method). Theoretically, the antibodies present in higher concentrations, which are more likely to react with donor antigens, will have higher MFI values. Since risk stratification based on MFI range is not standardized and the exact cutoffs vary from lab to lab, this term is intended to report those HLA antibodies found in an intermediate risk stratification of MFI values (For one lab this was 4999 > MFI > 2000, but some laboratories use other values).
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- HLA-A & B & C (class I) Ab.IgG intermediate risk
- Property
- Prid
- Time
- Pt
- System
- Ser/Plas
- Scale
- Nom
- Method
- Flow cytometry
Additional Names
- Short Name
- HLA class I Ab.IgG med risk SerPl FC
- Display Name
- HLA-A & B & C (class I) Ab.IgG intermediate risk FC Nom
- Consumer Name Alpha Get Info
- HLA-A & B & C (class I) Ab.IgG intermediate risk, Blood
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Observation
Example Answer List LL5520-3
Answer | Code | Score | Answer ID |
---|---|---|---|
Anti-A1 | LA23858-6 | ||
Anti-A2 | LA23859-4 | ||
Anti-A3 | LA23860-2 | ||
Anti-A9 | LA23861-0 | ||
Anti-A11 | LA23863-6 | ||
Anti-A28 | LA23864-4 | ||
Anti-A29 | LA23865-1 | ||
Anti-B7 | LA23870-1 | ||
Anti-B12 | LA23872-7 | ||
Anti-B13 | LA23873-5 | ||
Anti-B22 | LA23876-8 | ||
Anti-B27 | LA23877-6 | ||
Anti-B35 | LA23878-4 | ||
Anti-B41 | LA23880-0 | ||
Anti-Cw1 | LA23886-7 | ||
Anti-Cw4 | LA23888-3 | ||
Anti-Cw5 | LA23889-1 | ||
Anti-Cw3 | LA23890-9 | ||
Anti-Cw7 | LA23892-5 |
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-A, B, C (class I) riesgo intermedio por Ac IgG: |
es-MX | Spanish (Mexico) | HLA-A & B & C (clase I) Ab.IgG riesgo intermedio: |
fr-FR | French (France) | HLA-A et B et C (classe I) anticorps IgG MFI moyenne: |
it-IT | Italian (Italy) | HLA-A & B & C (classe I) Ab.IgG, rischio intermedio: Synonyms: Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi HLA-A e B e C (classe I) Plasma Presenza o Identità Punto nel tempo (episodio) Rischio intermedio di HLA-A & |
nl-NL | Dutch (Netherlands) | HLA A & B & C (klasse I) As.IgG intermediair risico: |
pl-PL | Polish (Poland) | HLA-A & B & C (klasa I) Ab.IgG średniego ryzyka: Synonyms: IgG Przeciwciała do antygenu I układu grupowego krwi Ii Przeciwciała IgG do HLA-A, B i C (klasa I) Przeciwciała IgG do HLA-A, B i C (klasa I) średniego ryzyka |
zh-CN | Chinese (China) | HLA-A 与 B 与 C (I 类) 抗体.IgG 中度风险: Synonyms: A 型 A,B 型; |
94449-6 HLA-A and B and C (class I) IgG high risk [Identifier] in Serum or Plasma by Flow cytometry (FC)
Term Description
Laboratories that perform HLA antibody testing often report the specific antibodies found in categories based on the "amount" of each antibody found (called mean fluorescent intensity, MFI, for the common Luminex bead method). Theoretically, the antibodies present in higher concentrations, which are more likely to react with donor antigens, will have higher MFI values. Since risk stratification based on MFI range is not standardized and the exact cutoffs vary from lab to lab, this term is intended to report those HLA antibodies found in the higher risk stratification of MFI values (For one lab this was MFI > 5000, but some laboratories use 10,000 or another value).
Source: Regenstrief LOINC
Part Descriptions
LP417652-7 HLA-A & B & C (class I) Ab.IgG high risk
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.
Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- HLA-A & B & C (class I) Ab.IgG high risk
- Property
- Prid
- Time
- Pt
- System
- Ser/Plas
- Scale
- Nom
- Method
- Flow cytometry
Additional Names
- Short Name
- HLA class I Ab.IgG high risk SerPl FC
- Display Name
- HLA-A & B & C (class I) Ab.IgG high risk FC Nom
- Consumer Name Alpha Get Info
- HLA-A & B & C (class I) Ab.IgG high risk, Blood
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Observation
Example Answer List LL5520-3
Answer | Code | Score | Answer ID |
---|---|---|---|
Anti-A1 | LA23858-6 | ||
Anti-A2 | LA23859-4 | ||
Anti-A3 | LA23860-2 | ||
Anti-A9 | LA23861-0 | ||
Anti-A11 | LA23863-6 | ||
Anti-A28 | LA23864-4 | ||
Anti-A29 | LA23865-1 | ||
Anti-B7 | LA23870-1 | ||
Anti-B12 | LA23872-7 | ||
Anti-B13 | LA23873-5 | ||
Anti-B22 | LA23876-8 | ||
Anti-B27 | LA23877-6 | ||
Anti-B35 | LA23878-4 | ||
Anti-B41 | LA23880-0 | ||
Anti-Cw1 | LA23886-7 | ||
Anti-Cw4 | LA23888-3 | ||
Anti-Cw5 | LA23889-1 | ||
Anti-Cw3 | LA23890-9 | ||
Anti-Cw7 | LA23892-5 |
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-A, B, C (clase I) alto riesgo por Ac IgG: |
es-MX | Spanish (Mexico) | HLA-A & B & C (clase I) Ab.IgG alto riesgo: |
fr-FR | French (France) | HLA-A et B et C (classe I) anticorps IgG MFI forte: |
it-IT | Italian (Italy) | HLA-A & B & C (classe I) Ab.IgG, rischio elevato: Synonyms: Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi HLA-A e B e C (classe I) Plasma Presenza o Identità Punto nel tempo (episodio) Rischio elevato di HLA-A & |
nl-NL | Dutch (Netherlands) | HLA A & B & C (klasse I) As.IgG hoog risico: |
pl-PL | Polish (Poland) | HLA-A & B & C (klasa I) Ab.IgG wysokiego ryzyka: Synonyms: IgG Przeciwciała do antygenu I układu grupowego krwi Ii Przeciwciała IgG do HLA-A, B i C (klasa I) Przeciwciała IgG do HLA-A, B i C (klasa I) wysokiego ryzyka |
zh-CN | Chinese (China) | HLA-A 与 B 与 C (I 类) 抗体.IgG 高度风险: Synonyms: A 型 A,B 型; |
94445-4 HLA-A IgG Ab [Identifier] in Serum or Plasma by Flow cytometry (FC)
Term Description
This term will report antibodies detected against specific HLA antigens at the serologic type level. However, some high specificity assays,such as the Luminex single bead system, can detect epitopes at a more detailed molecular allele-equivalent level. Therefore, many laboratories using this assay will report, along with the serotype, the molecular type, and also the mean fluorescence intensity (MFI) in a single answer. This term is intended to cover the existing reporting formats for HLA-A antibody specificity.
Source: Regenstrief LOINC
Part Descriptions
LP193956-2 HLA-A Ab.IgG
HLA-A, along with HLA-B and HLA-C, is a class I major histocompatibility complex (MHC) receptor, which are keys to antigen presentation in the immune system. It is coded by the HLA-A gene located at human chromosome 6p21.3. The class I molecules are heterodimers composed of one alpha subunit (the product of the class I gene) and a beta subunit, beta2 microglobulin. The high variability of this class of molecules is likely key to protecting the humans from pathogens, as it is more likely that a subset of the population will be highly immune to any given pathogen, and this diversity is reflected in the hundreds to thousands of possible alleles. However, the variability in HLA is also the reason for transplant rejection, and the detection of HLA antibodies in the transplant recipient has become a critical pre-transplant assessment. [https://www.genecards.org/cgi-bin/carddisp.pl?gene=HLA-A]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- HLA-A Ab.IgG
- Property
- Prid
- Time
- Pt
- System
- Ser/Plas
- Scale
- Nom
- Method
- Flow cytometry
Additional Names
- Short Name
- HLA-A IgG SerPl FC
- Display Name
- HLA-A IgG FC Nom
- Consumer Name Alpha Get Info
- HLA-A IgG antibody, Blood
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Observation
Example Answer List LL5522-9
Answer | Code | Score | Answer ID |
---|---|---|---|
Anti-A2 (A*02:01) | LA30696-1 | ||
Anti-A2 (A*02:03) | LA30697-9 | ||
Anti-A11 (A*11:01) | LA30698-7 | ||
Anti-A25 (A*25:01) | LA30699-5 | ||
Anti-A29 (A*29:02) | LA30700-1 | ||
Anti-A36 (A*36:01) | LA30701-9 | ||
Anti-A68 (A*68:02) | LA30702-7 | ||
Anti-A74 (A*74:01) | LA30703-5 |
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-A IgG: |
es-MX | Spanish (Mexico) | HLA-A Ab.IgG: |
fr-FR | French (France) | HLA-A anticorps IgG: |
fr-BE | French (Belgium) | HLA-A Anticorps. IgG: Synonyms: Anticorps |
fr-CA | French (Canada) | HLA-A, IgG: |
it-IT | Italian (Italy) | HLA-A Ab.IgG: Synonyms: anticorpi IgG anticorpo Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi Plasma Presenza o Identità Punto nel tempo (episodio) Siero Siero o Plasma |
nl-NL | Dutch (Netherlands) | HLA-A As.IgG: Synonyms: antistof; |
ru-RU | Russian (Russian Federation) | HLA-A Ат.IgG: Synonyms: Антитело Номинальный; |
tr-TR | Turkish (Turkey) | HLA-A Ab.IgG: Synonyms: Ak Ak.IgG Akış hücremetresi |
zh-CN | Chinese (China) | HLA-A 抗体.IgG: Synonyms: A IgG A 型 A 型抗体 Ab.IgG; |
94444-7 HLA-B IgG Ab [Identifier] in Serum or Plasma by Flow cytometry (FC)
Term Description
This term will report antibodies detected against specific HLA antigens at the serologic type level. However, some high specificity assays,such as the Luminex single bead system, can detect epitopes at a more detailed molecular allele-equivalent level. Therefore, many laboratories using this assay will report, along with the serotype, the molecular type, and also the mean fluorescence intensity (MFI) in a single answer. This term is intended to cover the existing reporting formats for HLA-B antibody specificity.
Source: Regenstrief LOINC
Part Descriptions
LP18320-9 HLA-B
Human Leukocyte Antigen B*27 (subtypes B*2701-2724) is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6. It presents microbial antigens to T-cells and is strongly associated with certain immunity diseases (SpA spondyloarthropathies). In the general population, about 8% Caucasian, 4% African, 2-9% Chinese, and 0.1-0.5% Japanese have the HLA-B27 antigen. In Northern Scandinavia (Lapland), 24% of people are HLA-B27 positive while 1.8% have ankylosing spondylitis (AS). Mystery:The relationship between HLA-B27 and many diseases has not yet been fully elucidated. Though it is associated with a wide range of pathology, it does not appear to be the sole mediator in development of disease. For example, while nearly all people with ankylosing spondylitis (AS) are HLA-B27 positive, only a fraction of people with HLA-B27 ever develop AS.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, HLA-B (Wikipedia)
Fully-Specified Name
- Component
- HLA-B Ab.IgG
- Property
- Prid
- Time
- Pt
- System
- Ser/Plas
- Scale
- Nom
- Method
- Flow cytometry
Additional Names
- Short Name
- HLA-B IgG SerPl FC
- Display Name
- HLA-B IgG FC Nom
- Consumer Name Alpha Get Info
- HLA-B IgG antibody, Blood
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Observation
Example Answer List LL5526-0
Answer | Code | Score | Answer ID |
---|---|---|---|
Anti-B7 (B*07:02) | LA30704-3 | ||
Anti-B75 (B*15:02) | LA30705-0 | ||
Anti-B18 (B*18:01) | LA30706-8 | ||
Anti-B27 (B*27:08) | LA30707-6 | ||
Anti-B37 (B*37:01) | LA30708-4 | ||
Anti-B57 (B*57:01) | LA30709-2 | ||
Anti-B57 (B*57:03) | LA30710-0 | ||
Anti-B82 (B*82:01) | LA30711-8 |
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-B IgG: |
es-MX | Spanish (Mexico) | HLA-B Ab.IgG: |
fr-FR | French (France) | HLA-B anticorps IgG: |
fr-BE | French (Belgium) | HLA-B Anticorps. IgG: Synonyms: Anticorps |
fr-CA | French (Canada) | HLA-B, IgG: |
it-IT | Italian (Italy) | HLA-B Ab.IgG: Synonyms: anticorpi IgG anticorpo Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi Plasma Presenza o Identità Punto nel tempo (episodio) Siero Siero o Plasma |
nl-NL | Dutch (Netherlands) | HLA-B As.IgG: Synonyms: antistof; |
ru-RU | Russian (Russian Federation) | HLA-B Ат.IgG: Synonyms: Антитело Номинальный; |
tr-TR | Turkish (Turkey) | HLA-B Ab.IgG: Synonyms: Ak Ak.IgG Akış hücremetresi |
zh-CN | Chinese (China) | HLA-B 抗体.IgG: Synonyms: Ab.IgG; |
94443-9 HLA-C IgG Ab [Identifier] in Serum or Plasma by Flow cytometry (FC)
Term Description
This term will report antibodies detected against specific HLA antigens at the serologic type level. However, some high specificity assays,such as the Luminex single bead system, can detect epitopes at a more detailed molecular allele-equivalent level. Therefore, many laboratories using this assay will report, along with the serotype, the molecular type, and also the mean fluorescence intensity (MFI) in a single answer. This term is intended to cover the existing reporting formats for HLA-C antibody specificity.
Source: Regenstrief LOINC
Part Descriptions
LP193954-7 HLA-C Ab.IgG
HLA-C, along with HLA-B and HLA-A, is a class I major histocompatibility complex (MHC) receptor, which are keys to antigen presentation in the immune system. It is coded by the HLA-C gene located on human chromosome 6. The class I molecules are heterodimers composed of one alpha subunit (the product of the class I gene) and a beta subunit, beta2 microglobulin. The high variability of this class of molecules is likely key to protecting the humans from pathogens, as it is more likely that a subset of the population will be highly immune to any given pathogen, and this diversity is reflected in the hundreds to thousands of possible alleles. However, the variability in HLA is also the reason for transplant rejection, and the detection of HLA antibodies in the transplant recipient has become a critical pre-transplant assessment. [https://www.genecards.org/cgi-bin/carddisp.pl?gene=HLA-C]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- HLA-C Ab.IgG
- Property
- Prid
- Time
- Pt
- System
- Ser/Plas
- Scale
- Nom
- Method
- Flow cytometry
Additional Names
- Short Name
- HLA-C IgG SerPl FC
- Display Name
- HLA-C IgG FC Nom
- Consumer Name Alpha Get Info
- HLA-C IgG antibody, Blood
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Observation
Example Answer List LL5527-8
Answer | Code | Score | Answer ID |
---|---|---|---|
Anti-Cw1 (C*01:02) | LA30712-6 | ||
Anti-Cw10 (C*03:02) | LA30713-4 | ||
Anti-Cw10 (C*03:04) | LA30714-2 | ||
Anti-Cw4 (C*04:01) | LA30715-9 | ||
Anti-Cw5 (C*05:01) | LA30716-7 | ||
Anti-Cw12 (C*12:03) | LA30717-5 | ||
Anti-Cw15 (C*15:02) | LA30718-3 | ||
Anti-Cw16 (C*16:01) | LA30719-1 |
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-C IgG: |
es-MX | Spanish (Mexico) | HLA-C Ab.IgG: |
fr-FR | French (France) | HLA-C anticorps IgG: |
fr-BE | French (Belgium) | HLA-C Anticorps. IgG: Synonyms: Anticorps |
fr-CA | French (Canada) | HLA-C, IgG: |
it-IT | Italian (Italy) | HLA-C Ab.IgG: Synonyms: anticorpi IgG anticorpo Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi Plasma Presenza o Identità Punto nel tempo (episodio) Siero Siero o Plasma |
nl-NL | Dutch (Netherlands) | HLA-C As.IgG: Synonyms: antistof; |
ru-RU | Russian (Russian Federation) | HLA-C Ат.IgG: Synonyms: Антитело Номинальный; |
tr-TR | Turkish (Turkey) | HLA-C Ab.IgG: Synonyms: Ak Ak.IgG Akış hücremetresi |
zh-CN | Chinese (China) | HLA-C 抗体.IgG: Synonyms: Ab.IgG; |
72328-8 HLA-A+B+C (class I) IgG Ab [Presence] in Serum by Flow cytometry (FC)
Term Description
IgG antibodies to HLA class I antigens (A, B, and C) can be detected by flow cytometry in serum of pre and post-transplant organ recipients. A positive result is an indication of a sensitization to HLA antigens. This code is based on, but not exclusive to, the submitter's test kit, One Lambda's FlowPRA Screening Test, which uses beads coated with common and rare purified HLA Class I or II antigens.
Source: Regenstrief LOINC
Part Descriptions
LP156720-7 HLA-A+B+C Ab.IgG
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.
Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- HLA-A+B+C Ab.IgG
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- Flow cytometry
Additional Names
- Short Name
- HLA-A+B+C IgG Ser Ql FC
- Display Name
- HLA-A+B+C (class I) IgG FC Ql (S)
- Consumer Name Alpha Get Info
- HLA-A+B+C (class I) IgG antibody, Blood
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.42
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Example Answer List LL360-9
Answer | Code | Score | Answer ID |
---|---|---|---|
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
72905-3 | Neutrophil Ab and HLA Ab screen panel - Serum or Plasma |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-A+B+C IgG: |
es-MX | Spanish (Mexico) | HLA-A + B + C Ab.IgG: |
et-EE | Estonian (Estonia) | HLA-A+B+C antikehad.IgG: Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Seerum |
fr-CA | French (Canada) | HLA-A+B+C, IgG: |
fr-FR | French (France) | HLA-A+B+C anticorps IgG: |
fr-BE | French (Belgium) | HLA-A+B+C Anticorps. IgG: Synonyms: Anticorps |
it-IT | Italian (Italy) | HLA-A+B+C Ab.IgG: Synonyms: anticorpi IgG anticorpo Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi Presenza o Soglia Punto nel tempo (episodio) Siero |
nl-NL | Dutch (Netherlands) | HLA-A+B+C As.IgG: Synonyms: antistof; |
pt-BR | Portuguese (Brazil) | HLA-A+B+C Ac.IgG: |
ru-RU | Russian (Russian Federation) | HLA-A+B+C Ат.IgG: Synonyms: Антитело Порядковый Сыворотка Точка во времени; |
tr-TR | Turkish (Turkey) | HLA-A+B+C Ab.IgG: Synonyms: Ak Ak.IgG Akış hücremetresi Mevcut |
zh-CN | Chinese (China) | HLA-A+B+C 抗体.IgG: Synonyms: A 型 A,B 型; |
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.
80737-0 Calculated panel reactive antibody - Serum
Term Description
A patient's "calculated panel reactive antibody" (cPRA) determines the likelihood that a transplant recipient and donor would be incompatible. The cPRA is calculated based on how many and which HLA antibodies the patient has compared to known information about the HLA antigen frequencies from ~1200 donors from 2003-2005. PMID: 19958328 The more antibodies the patient has and the more common the HLA antigens are in the donor pool, the higher the cPRA. Calculated cPRA is not the same as a patient's percent PRA, which is simply the percentage of a pool of donors (~100) to which a patient had reactive antibodies (see the HLA Ab panel [LOINC: 46993-2]). Note that "panel" is part of the antibody name and a single result is expected. This is not panel term.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Calculated panel reactive antibody
- Property
- RelRto
- Time
- Pt
- System
- Ser
- Scale
- Qn
- Method
- Calculated
Additional Names
- Short Name
- cPRA Ser Calc
- Display Name
- Calculated panel reactive antibody Calc (S) [Relative ratio]
- Consumer Name Alpha Get Info
- Calculated panel reactive antibody, Blood
Basic Attributes
- Class
- HLA
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.65
- Order vs. Observation
- Both
Formula (Readable)
cPRA calculator is available at https://optn.transplant.hrsa.gov/resources/allocation-calculators/cpra-calculator/
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
94440-5 | HLA-DP and DQ and DR (class II) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Panel de anticuerpos reactivos calculados: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Anticuerpo reactivo de panel calculado: |
fr-FR | French (France) | Anticorps réactifs panel calculé (cPRA): |
it-IT | Italian (Italy) | Panel anticorpi reattivi calcolato: Synonyms: HLA tipizzazione tissutale antigeni-anticorpi Punto nel tempo (episodio) Rapporto Relativo Siero |
nl-NL | Dutch (Netherlands) | berekend panel reactieve antistoffen: |
zh-CN | Chinese (China) | 群体反应性抗体计算值: Synonyms: HLA 抗原; |
Example Units
Unit | Source |
---|---|
{ratio} | Example UCUM Units |
8100-0 Specimen preparation [Type]
Fully-Specified Name
- Component
- Specimen preparation
- Property
- Type
- Time
- Pt
- System
- XXX
- Scale
- Nom
- Method
- *
Additional Names
- Short Name
- Specimen preparation
- Display Name
- Specimen preparation Nom (Specimen)
- Consumer Name Alpha Get Info
- Specimen preparation, Specimen
Basic Attributes
- Class
- SPEC
- Type
- Laboratory
- First Released
- Version 1.0h(2)
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 2431
Member of these Panels
LOINC | Long Common Name |
---|---|
96046-8 | B and T cell crossmatch panel - Patient serum and Donor blood by Flow cytometry (FC) |
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
94440-5 | HLA-DP and DQ and DR (class II) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-AR | Spanish (Argentina) | preparación del espécimen: |
es-ES | Spanish (Spain) | Preparación de la muestra: |
es-MX | Spanish (Mexico) | Preparación de espécimen: |
fr-CA | French (Canada) | Préparation de l'échantillon: |
fr-FR | French (France) | Préparation du prélèvement: |
fr-BE | French (Belgium) | Préparation de l'échantillon: |
it-IT | Italian (Italy) | Campione, preparazione: Synonyms: Caratteristiche campione Preparazione del campione Punto nel tempo (episodio) |
nl-NL | Dutch (Netherlands) | monsterpreparatie: |
pl-PL | Polish (Poland) | Przygotowanie próbki: |
pt-BR | Portuguese (Brazil) | Preparação da amostra: Synonyms: Typ; |
ru-RU | Russian (Russian Federation) | Образец подготовка: Synonyms: Номинальный; |
zh-CN | Chinese (China) | 标本制备: Synonyms: 不明的; |
94431-4 Dilution factor [Titer] in Serum or Plasma
Fully-Specified Name
- Component
- Dilution factor
- Property
- Titr
- Time
- Pt
- System
- Ser/Plas
- Scale
- SemiQn
- Method
Additional Names
- Short Name
- Dilution factor Titr SerPl
- Display Name
- Dilution factor [Titer]
- Consumer Name Alpha Get Info
- Dilution factor, Blood
Basic Attributes
- Class
- MISC
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.75
- Order vs. Observation
- Observation
Member of these Panels
LOINC | Long Common Name |
---|---|
94428-0 | HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC) |
94446-2 | HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC) |
94440-5 | HLA-DP and DQ and DR (class II) IgG panel - Serum or Plasma by Flow cytometry (FC) |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Factor de dilución: Synonyms: Semicuantitativo |
es-MX | Spanish (Mexico) | Factor de dilución: |
fr-FR | French (France) | Facteur de dilution: |
it-IT | Italian (Italy) | Diluizione, fattore: Synonyms: Fattore di diluizione Miscellanea Plasma Punto nel tempo (episodio) Siero Siero o Plasma Titolo |
nl-NL | Dutch (Netherlands) | verdunningsfactor: |
zh-CN | Chinese (China) | 稀释倍数: Synonyms: 因素 效价; |
Example Units
Unit | Source |
---|---|
{titer} | Example UCUM Units |