Version 2.77

Status Information

Map-To Long Common Name Mapping Guidance
2098-2 Cholinesterase [Enzymatic activity/volume] in Serum or Plasma

Part Descriptions

LP14299-9   Cholinesterase
In biochemistry, cholinesterase is a family of enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.

There are two types:
1. Acetylcholinesterase (EC (AChE), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form (10) with much smaller amounts of a monomeric G1 (4S) form.
2. Pseudocholinesterase (EC (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver.

The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.

The half-life of pseudocholinesterase is approximately 8-16 hours. Pseudocholinesterase levels may be reduced in patients with advanced liver disease. The decrease must be greater than 75% before significant prolongation of neuromuscular blockade occurs with succinylcholine.

An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.
Pseudocholinesterase deficiency may also affect local anaesthetic selection in dental procedures. The enzyme plays an important role in the metabolism of ester-based local anaesthetics, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anaesthetic. The selection of an amide-based solution is recommended in such patients.
Elevation of plasma pseudocholinesterase was observed in 90.5% cases of acute myocardial infarction.
The presence of acetylcholinesterase in the amniotic fluid may be tested in early pregnancy. A sample of amniotic fluid is removed by amniocentesis, and presence of AChE can confirm several common types of birth defect, including abdominal wall defects and neural tube defects.
Butyrylcholinesterase can be used as a prophylactic agent against nerve gas and other organophosphate poisoning Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, Cholinesterase (Wikipedia)

LP14299-9   Cholinesterase
Cholinesterase is measured to diagnose organophosphate and carbamate toxicity or identify atypical enzyme forms. RBC levels measured to detect chronic exposure to systemic insecticides. Insecticides inhibit both RBC and plasma cholinesterase levels, but serum levels return to normal before RBC levels normalize. Cholinesterase is irreversibly inhibited by organophosphate insecticides and reversibly inhibited by carbamate insecticides. Information from LOINC partner 1 2006 10 24.

Pseudocholinesterase is also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acyl choline acylhydrolase, found primarily in the liver. An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency, which is a silent condition which only manifests itself when people who have the deficiency receive the muscle relaxants succinylcholine or mivacurium during surgery. Information from Source: Regenstrief Institute

Fully-Specified Name


Additional Names

Short Name
Deprecated Cholinesterase Ser-cCnc
Display Name
Cholinesterase (S) [Catalytic activity/Vol]
Consumer Name Alpha Get Info
Cholinesterase, Blood

Basic Attributes

First Released
Version 1.0i
Last Updated
Version 2.36

Member of these Groups Get Info

LOINC Group Group Name
LG246-5 Cholinesterase|CCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) colinesterasa:concentración catalítica:punto en el tiempo:suero:cuantitativo:
es-MX Spanish (Mexico) Colinesterasa:Concentración catalítica:Punto temporal:Suero:Cuantitativo:
es-ES Spanish (Spain) Colinesterasa:Concentración Catalítica:Punto temporal:Suero:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Koliini esteraas:CCnc:Pt:S:Qn:
Synonyms: Juhuslik Kvantitatiivne Seerum
fr-CA French (Canada) Cholinestérase:Concentration catalytique:Temps ponctuel:Sérum:Quantitatif:
fr-BE French (Belgium) Cholinestérase:Concentration catalytique:Temps ponctuel:Sérum:Quantitatif:
it-IT Italian (Italy) Colinesterasi:CCnC:Pt:Siero:Qn:
Synonyms: Chimica Concentrazione Catalitica Punto nel tempo (episodio) Siero
nl-NL Dutch (Netherlands) cholinesterase:enzymatische activiteit/volume:moment:serum:kwantitatief:
pl-PL Polish (Poland) Cholinoesteraza:stężenie katalityczne:punkt w czasie:surowica:ilościowy:
pt-BR Portuguese (Brazil) Colinesterase:CCnc:Pt:Soro:Qn:
Synonyms: Pseudocho; CHS; Che; BChE; Benzoylcholinesterase; Butyrylcholine esterase; Pseudocholinesterase; Choline esterase II; Benzoyl cholinesterase; Acylcholine acylhydrolase; Catalytic Concentration; Point in time; Random; Serum; SR; Quantitative; QNT; Quant; Quan; Chemistry
ru-RU Russian (Russian Federation) Холинэстераза:КаталКонц:ТчкВрм:Сыв:Колич:
Synonyms: Каталитическая концентрация Количественный Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) Kolinesteraz:KtlKons:Zmlı:Ser:Kant:
zh-CN Chinese (China) 胆碱酯酶:催化浓度:时间点:血清:定量型:
Synonyms: BChE;Che;CHS;Pseudocho;丁酰胆碱酯酶;伪胆碱脂酶;假性胆碱脂酶;假胆碱酯酶;拟胆碱酯酶;胆碱酯酶 II;胆碱酯酶Ⅱ;脂酰胆碱酯酰水解酶;苯甲酰胆碱酯酶;苯酰胆碱酯酶 催化浓度(单位体积);单位体积内酶的单位数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间

Example Units

Unit Source
U/L Example UCUM Units

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