95223-4

Mononuclear cells/Leukocytes in Stem cell product by Manual count

Active

Part Descriptions

LP157588-7   Leukocytes
Leukocytes or white blood cells (WBCs) are immune cells that fight infection, neoplasms and other inflammatory conditions, and mediate allergic responses. There are five types of WBCs normally present in the circulation that are all derived from a similar stem cell in the bone marrow. The five type of WBCs are divided into two groups based on the presence or absence of granules in the cytoplasm. The granulocytes include the neutrophils, basophils and eosinophils. The non-granulocytes include the lymphocytes and the monocytes. The neutrophils fight infection by ingesting and digesting bacteria. Eosinophils and basophils respond to allergic reactions and are capable of ingesting antigen-antibody complexes. Monocytes phagocytose bacteria and release interferon to stimulate the immune system. Lymphocytes are divided into T-cells and B-cells. T-cell immunity is cellular and involves the activation of phagocytes and B-cell immunity uses antibodies to fight infection. Both elevated and low leukocyte counts can be markers of infection and malignancy, and low leukocyte counts are associated with a variety of primary and secondary immunodeficiencies, depending on the WBC type(s) that are out of range. (Mosby's manual of diagnostic and laboratory tests, Kathleen Deska Pagana; Timothy James Pagana, Elsevier St. Louis, Mo ©2010) Source: Regenstrief LOINC

LP17839-9   Mononuclear cells
A Peripheral Blood Mononuclear Cell (PBMC) is a blood cell having a round nucleus, such as a lymphocyte or a monocyte. These blood cells are a critical component in the immune system to fight infection and adapt to intruders. The lymphocyte population consists of T cells (CD4 and CD8 positive ~75%), B cells and NK cells (~25% combined).

These cells are often extracted from whole blood using ficoll, a hydrophilic polysaccharide that separates layers of blood, with monocytes and lymphocytes forming a buffy coat under a layer of plasma. This buffy coat contains the PBMCs. Additionally, PBMC can be extracted from whole blood using a hypotonic lysis which will preferentially lyse red blood cells. This method results in neutrophils and other polymorphonuclear (PMN) cells which are important in innate immune defense to be obtained.

PBMCs are widely used in research and clinical uses every day. HIV research uses them because PBMCs include CD4+ cells, the cells HIV infects. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Mononuclear cell

LP281774-2   ^Stem cell product
Bone marrow or peripheral blood hematopoietic stem cells are collected for patients scheduled to undergo stem cell (bone marrow) transplantation. For autologous transplants, the patient donates his or her own cells. For allogeneic transplants, a healthy donor provides cells for a patient. Collected cells (harvested by aspiration from the marrow or by therapeutic apheresis from the blood after treatment of the donor with a stem cell mobilizing agent such filgrastim) are processed to concentrate the stem cells. Stem cells may be further processed in a variety of ways, depending upon the source and volume of stem cells and the diagnosis of the recipient. In selected cases, the concentrated stem cell preparation is processed to concentrate or eliminate cells found in the collection. A special chemical mixture is added to protect cells during freezing, and they are frozen and stored at temperatures below 80 degrees Celsius until thawed for infusion into the patient. Stem cell transplantation is used to replace diseased bone marrow, as in leukemia, or as an adjunctive measure for patients undergoing high-dose chemotherapy and/or radiotherapy. For some diagnoses, stem cell transplantation procedures are experimental. New York Blood Center, accessed 20081218. Source: Regenstrief Institute , Stem cell product

Fully-Specified Name

Component

Mononuclear cells/Leukocytes

Property

NFr

Time

Pt

System

^Stem cell product

Scale

Qn

Method

Manual count

Additional Names

Long Common Name

Mononuclear cells/Leukocytes in Stem cell product by Manual count

Short Name

Mononuc Cells NFr Stem prod Manual

Display Name

Mononuclear cells/Leukocytes Manual cnt (Stem cell product)

Consumer Name Alpha Get Info

Mononuclear cells/White Blood Cells, Stem Cell Product

Basic Attributes

Class

HEM/BC

Type

Laboratory

First Released

Version 2.68

Last Updated

Version 2.79 (NAM)

Change Reason

Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;

Order vs. Observation

Observation

Member of these Panels

Language Variants Get Info

Related Names

• Cell
• Cellularity
• Hematology
• HEMATOLOGY/CELL COUNTS
• Heme
• Leuc
• Leuk
• Leukocyte
• Lkcs
• Manl
• Mononuc
• Mononuc Cells
• Number Fraction
• Percent
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Stem prod
• WBC
• WBCs
• White blood cell
• White blood cells

Example Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.

CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95223-4

LOINC Copyright

Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.