LOINC
Version 2.69

95411-5SARS-CoV-2 (COVID-19) neutralizing antibody [Presence] in Serum by pVNTActive

Term Description

Qualitative results for SARS Coronavirus 2 (SARS-CoV-2) virus neutralizing antibodies in serum by pVNT (pseudovirus neutralization test). Neutralizing antibody testing is performed to determine whether the antibodies produced after SARS-CoV-2 infection or in response to a vaccination are able to neutralize the virus and prevent infection or re-infection. Different methods can be used to determine the presence of neutralizing antibodies, including VNT (virus neutralization test) and pVNT, which are represented in LOINC as the Method "Neutralization" and "pVNT", respectively. The pVNT method for SARS-CoV-2 neutralizing antibody testing uses recombinant pseudoviruses that incorporate the S protein from SARS-CoV-2, whereas VNT uses SARS-CoV-2 virus from a clinical isolate or recombinant SARS-CoV-2 expressing reporter proteins.
Source: Regenstrief LOINC

Part Description

LP417540-4   SARS coronavirus 2
The 2019 Novel Coronavirus (2019-nCoV) is a coronavirus first identified as the cause of a respiratory illness outbreak in Wuhan, China. Initially, the outbreak was linked to a large seafood and animal market and thought to only be spread by animal to person contact. Within a short time, a growing number of patients who had not been exposed to animal markets were diagnosed with the infection, indicating person-to-person transmission. As of January 2020, infections with 2019-nCoV have been reported internationally, including Thailand and the United States, in due to confirmed cases in travelers from Wuhan. Overall, clinical symptoms appear milder than SARS Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome (MERS) Coronavirus (MERS-CoV) infections as do the fatality rate and transmissibility. [PMID: 31953166] Reported illnesses have ranged from minor or no respiratory symptoms to severe acute respiratory illness and death.

The full genome of the 2019-nCoV was first posted by Chinese health authorities in GenBank, the NIH genetic sequence database, and in the Global Initiative on Sharing All Influenza Data (GISAI) portal. This facilitated detection of the virus globally with subsequent sequences being nearly identical, suggesting a single, recent emergence from a virus related to bat coronaviruses and the SARS coronavirus. Real time Reverse Transcription-Polymerase Chain Reaction (rRT-PCR) tests have been developed by the Centers for Disease Control and Prevention (CDC) and others for the diagnosis of 2019-nCoV. The existing 2019-nCoV primer and probe sets are designed for the universal detection of SARS-like coronaviruses and for specific detection of 2019-nCoV.[CDC: coronavirus/2019-ncov] Source: LOINC

Fully-Specified Name

Component
SARS coronavirus 2 Ab.neut
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
pVNT

Additional Names

Short Name
SARS-CoV-2 NAb Ser Ql pVNT
Display Name
SARS-CoV-2 (COVID-19) neut ab pVNT Ql (S)
Consumer Name Alpha
SARS-CoV-2 (COVID-19) neutralizing antibody, Blood

Ask At Order Entry

This panel contains a convenience grouping of terms for questions commonly asked when an order is placed in a public health laboratory.

LOINC Name R/O/C Cardinality Example UCUM Units
81959-9 Public health laboratory ask at order entry panel
Indent81744-5 Submitter's laboratory test method [Type] in Specimen
Indent81658-7 Suspected organism [Identifier] in Specimen
Indent86952-9 Preliminary testing done Specimen
Indent86953-7 Preliminary testing result Specimen
Indent86955-2 Preliminary testing affected submission for further testing Specimen
Indent95417-2 Whether this is the patient's first test for condition of interest
Indent95418-0 Whether patient is employed in a healthcare setting
Indent95419-8 Whether the patient has symptoms related to condition of interest
Indent11368-8 Illness or injury onset date and time C
Indent77974-4 Whether the patient was hospitalized for condition of interest
Indent95420-6 Whether the patient was admitted to intensive care unit (ICU) for condition of interest
Indent95421-4 Whether patient resides in a congregate care setting
Indent82810-3 Pregnancy status C
Indent30525-0 Age a

Example Answer List LL2009-0

Source: ARUP Laboratories

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Equivocal Copyright http://snomed.info/sct ID:42425007 Equivocal (qualifier value) LA11885-3

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.69
Order vs. Observation
Both

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright © 2001-2019 American Association for Clinical Chemistry Coronavirus (COVID-19) Testing

Member of these Groups

LG51018-6 SARSCoV2 antibody detection

Language Variants Get Info

zh-CNChinese (China)
SARS 冠状病毒 2 抗体.中和:存在情况或阈值:时间点:血清:序数型:假病毒中和试验
nl-NLDutch (Netherlands)
SARS-CoV-2 As.neutraliserend:aanwezigheid:moment:serum:ordinaal:pseudovirus-neutralisatietest
it-ITItalian (Italy)
SARS coronavirus 2 Ab.Neut:PrThr:Pt:Siero:Ord:pVNT

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95411-5