95726-6

3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab [Units/volume] in Serum or Plasma by Immunoassay

Active

Part Description

LP220363-8 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase (HMG-CoA reductase or HMGCR) is an enzyme in the cholesterol-synthesis pathway and is the target of HMG-CoA reductase inhibitors, also known as statins. Autoantibodies to HMGCR may be a marker of necrotizing autoimmune myopathy (NAM), which is characterized by muscle fiber necrosis with little or no inflammation and responsiveness to immunosuppressive treatment. Anti-HMGCR positive cases of NAM usually have limited extramuscular involvement, slow onset of muscle disease, and can occur in both adults and children. Due to the insidious onset, pediatric cases of NAM may be initially confused with muscular dystrophy. The anti-HMGCR antibody titer may correlate with muscle strength and creatine kinase level. Some cases of NAM have been diagnosed in patients previously exposed to statins, and in some of these cases, stopping the statin drug was the only intervention necessary for the resolution of disease. However, exposure to statins is not required to diagnose cases of NAM, and first-line treatment typically includes corticosteroids or other immunosuppressive drugs such as methotrexate. PMID: 24797170 Source: Regenstrief LOINC, PMID: 24797170

LOINC Names Get Info

Fully-Specified Name: 3-Hydroxy-3-Methylglutaryl-Coenzyme A reductase Ab:ACnc:Pt:Ser/Plas:Qn:IA
Long Common Name: 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab [Units/volume] in Serum or Plasma by Immunoassay
Short Name: HMGCR Ab SerPl IA-aCnc
Display Name: 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab IA Qn
Consumer Name Alpha Get Info: 3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase antibody, Blood

Part Model Get Info

Component
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
LP220363-8
- Analyte
  3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
  LP220363-8
  - Component Numerator
    3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
    LP220363-8
    - Component Numerator Core
      3-Hydroxy-3-Methylglutaryl-coenzyme A reductase
      LP220364-6
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IA
LP217197-5

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.69
Last Updated: Version 2.69 (ADD)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
97561-5	Necrotizing myopathy autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG51037-6	3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab\|ACnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	3-hydroxy-3-methylglutaryl-koenzym A reduktáza Ab:Arbitrární koncentrace:Časový bod:Sérum/plazma:Kvantitativní:Imunoanalýza
el-GR	Greek (Greece)	Αναγωγάση του 3-υδροξυ-3-μεθυλογλουταρυλο-συνενζύμου Α Αντίσωμα:ACnc:Pt:Ορός/Πλάσμα:Qn:IA Synonyms: A ACnc IA Pt Qn SERO Αναγωγάση του 3-υδροξυ-3-μεθυλογλουταρυλο-συνενζύμου Α Αντίσωμα Ορός Ορός/Πλάσμα Πλάσμα
es-ES	Spanish (Spain)	3-Hidroxy-3-metilglutaril-CoA reductasa Anticuerpos:Concentración arbitraria:Punto temporal:Suero o Plasma:Qn:IA Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	3-hidroxi-3-metilglutaril-coenzima A reductasa Ab:Concentración arbitraria:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
fr-FR	French (France)	3-hydroxy-3-méthyglutaryl-coenzyme A réductase Ac:Arbitraire/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
it-IT	Italian (Italy)	3-idrossi-3-metilglutaril-coenzima A reduttasi Ab:ACnc:Pt:Siero/Plasma:Qn:IA Synonyms: anticorpo Concentrazione Arbitraria Immunoassay Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	3-hydroxy-3-methylglutaryl-CoA-reductase As:eenheid/volume:moment:serum of plasma:kwantitatief:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	Reduktaza 3-hydroksy-3-metyloglutarylo-koenzymu A Ab:stężenie w jednostkach umownych:punkt w czasie:surowica lub osocze:ilościowy:metoda immunologiczna Synonyms: Reduktaza HMG-CoA
zh-CN	Chinese (China)	3-羟基-3-甲基戊二酰-辅酶 A 还原酶抗体:任意型浓度:时间点:血清/血浆:定量型:免疫测定法 Synonyms: 3-羟基-3-甲基戊二酰基-辅酶 A 还原酶;3-羟基-3-甲基戊二酰基辅酶 A 还原酶;3-羟基-3-甲基戊二酰辅酶 A 还原酶;3-羟基-3-甲基戊二酰-CoA 还原酶;3-羟基-3-甲基戊二酰基-CoA 还原酶;3-羟基-3-甲基戊二酰基 CoA 还原酶;3-羟基-3-甲基戊二酰 CoA 还原酶 Ⅲ A 型 Ab;自身抗体 Hydroxy III OH 三任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验叁可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间羟血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类血清或血浆

Example Units

Unit	Source
[IU]/L	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.