Version 2.79

Part Description

LP220363-8   3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase (HMG-CoA reductase or HMGCR) is an enzyme in the cholesterol-synthesis pathway and is the target of HMG-CoA reductase inhibitors, also known as statins. Autoantibodies to HMGCR may be a marker of necrotizing autoimmune myopathy (NAM), which is characterized by muscle fiber necrosis with little or no inflammation and responsiveness to immunosuppressive treatment. Anti-HMGCR positive cases of NAM usually have limited extramuscular involvement, slow onset of muscle disease, and can occur in both adults and children. Due to the insidious onset, pediatric cases of NAM may be initially confused with muscular dystrophy. The anti-HMGCR antibody titer may correlate with muscle strength and creatine kinase level. Some cases of NAM have been diagnosed in patients previously exposed to statins, and in some of these cases, stopping the statin drug was the only intervention necessary for the resolution of disease. However, exposure to statins is not required to diagnose cases of NAM, and first-line treatment typically includes corticosteroids or other immunosuppressive drugs such as methotrexate. PMID: 24797170 Source: Regenstrief LOINC , PMID: 24797170

Fully-Specified Name

Component
3-Hydroxy-3-Methylglutaryl-Coenzyme A reductase Ab
Property
ACnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
IA

Additional Names

Long Common Name
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab [Units/volume] in Serum or Plasma by Immunoassay
Short Name
HMGCR Ab SerPl IA-aCnc
Display Name
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab IA Qn
Consumer Name Alpha Get Info
3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.69 (ADD)
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
97561-5 Necrotizing myopathy autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group Group Name
LG51037-6 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Αναγωγάση του 3-υδροξυ-3-μεθυλογλουταρυλο-συνενζύμου Α Αντίσωμα:ACnc:Pt:Ορός/Πλάσμα:Qn:IA
Synonyms: A ACnc Αναγωγάση του 3-υδροξυ-3-μεθυλογλουταρυλο-συνενζύμου Α
es-ES Spanish (Spain) 3-Hidroxy-3-metilglutaril-CoA reductasa Anticuerpos:Concentración arbitraria:Punto temporal:Suero o Plasma:Qn:IA
Synonyms: Cuantitativo
es-MX Spanish (Mexico) 3-hidroxi-3-metilglutaril-coenzima A reductasa Ab:Concentración arbitraria:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
fr-FR French (France) 3-hydroxy-3-méthylglutaryl-coenzyme A réductase anticorps:Arbitraire/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
it-IT Italian (Italy) 3-idrossi-3-metilglutaril-coenzima A reduttasi Ab:ACnc:Pt:Siero/Plasma:Qn:IA
Synonyms: anticorpo Concentrazione Arbitraria Immunoassay Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) 3-hydroxy-3-methylglutaryl-CoA-reductase As:eenheid/volume:moment:serum of plasma:kwantitatief:immunoassay
Synonyms: antistof; antilichaam IA
zh-CN Chinese (China) 3-羟基-3-甲基戊二酰-辅酶 A 还原酶 抗体:任意型浓度:时间点:血清/血浆:定量型:免疫测定法
Synonyms: 3-羟基-3-甲基戊二酰基-辅酶 A 还原酶;3-羟基-3-甲基戊二酰基辅酶 A 还原酶;3-羟基-3-甲基戊二酰辅酶 A 还原酶;3-羟基-3-甲基戊二酰-CoA 还原酶;3-羟基-3-甲基戊二酰基-CoA 还原酶;3-羟基-3-甲基戊二酰基 CoA 还原酶;3-羟基-3-甲基戊二酰 CoA 还原酶 Ⅲ A 型 Ab;自身抗体 Hydroxy III OH 三 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 叁 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 羟 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆

Example Units

Unit Source
[IU]/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95726-6