Version 2.76

80382-5 Influenza virus A Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

Term Description

This term was created for, but is not limited in use to, the Influenza A part of the bioMerieux bioNexia Influenza A+B test, which is intended for the qualitative detection and differentiation of Influenza type A and type B antigens in human nasopharyngeal samples. The results of the bioNexia assay should be read ten minutes after the sample is applied to the sample well.
Source: Regenstrief LOINC

Part Descriptions

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. PMID: 20542248 ] PMID: 25812763
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A Ag
Property
PrThr
Time
Pt
System
Respiratory.upper
Scale
Ord
Method
IA.rapid

Additional Names

Short Name
FLUAV Ag Upper resp Ql IA.rapid
Display Name
FLUAV Ag IA.rapid Ql (Upper resp)
Consumer Name Alpha Get Info
Influenza A (Flu A) antigen, Upper respiratory

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.73
Change Reason
Release 2.70: SYSTEM: Updated from "Nph" to make the LOINC term consistent with the original intent to represent a manufacturer's test covering NPH washes and nose swabs, as well as to make it consistent across panel usage.; Previous Releases: Corrected System from "Nasopharynx", which is used for LOINC clinical terms, to "Nph", which is the form used for LOINC lab terms.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
1303

Example Answer List LL744-4

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Member of these Panels

LOINC Long Common Name
80381-7 Influenza virus A and B Ag panel - Upper respiratory specimen by Rapid immunoassay
97099-6 Influenza virus A and B and SARS-CoV-2 (COVID-19) Ag panel - Upper respiratory specimen by Rapid immunoassay
95942-9 Influenza virus A and B and SARS-CoV+SARS-CoV-2 (COVID-19) Ag panel - Upper respiratory specimen by Rapid immunoassay

Member of these Groups Get Info

LOINC Group Group Name
LG32757-3 Influenza virus
LG34020-4 Influenza virus A Ag|PrThr|Sys:ANYResp

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Influenza-Virus A Ag:Nachweis oder Schwellenwert:Zeitpunkt:Respirationstrakt.oberer:Ordinal:Immunoassay.schnell
es-ES Spanish (Spain) Virus Influenza A Antígeno:PrThr:Punto temporal:Muestra respiratoria de vías altas:Ord:IA.rapid
Synonyms: Muestra del tracto respiratorio superior Muestra respiratoria Muestra respiratoria superior
es-MX Spanish (Mexico) Virus de la influenza A Ag:Presencia o umbral:Punto temporal:Nasofaringe:Ordinal:Inmunoensayo rápido
fr-FR French (France) Influenza virus A Ag:Présence/Seuil:Ponctuel:Voies respiratoires supérieures:Qualitatif:Immunoanalyse rapide
it-IT Italian (Italy) Influenza A, virus , Ag:PrThr:Pt:Sistema respiratorio.superiore:Ord:IA.rapido
Synonyms: Campione apparato respiratorio superiore Immunoassay Immunoassay rapido Microbiologia Presenza o Soglia Punto nel tempo (episodio) Virus dell''influenza Virus dell''influenza A
nl-NL Dutch (Netherlands) Influenzavirus A Ag:aanwezigheid:moment:bovenste luchtwegen:ordinaal:immunoassay.sneltest
Synonyms: antigeen bovenste ademhalingsstelsel; systema respiratorium superior IA IA.rapid systema respiratorium; ademhalingsstelsel
pl-PL Polish (Poland) Wirus grypy A Ag:granica wykrywalności:punkt w czasie:próbka z górnych dróg oddechowych:półilościowy:szybka metoda immunologiczna
Synonyms: Antygen wirusa grypy typ A Wirus grypy Wirus grypy typ A
zh-CN Chinese (China) 流感病毒 A 型 抗原:存在情况或阈值:时间点:呼吸道.上:序数型:免疫测定法.快速
Synonyms: A 型 A 型抗原 A 型流感;A 型流感病毒;FLUA;FLUAV;家禽鼠疫;流感 A;流感 A 型;流感甲型;流感病毒甲型;甲型流感;甲型流感病毒;瘟疫;禽流感;禽流行性感冒;禽疫;鸡瘟 A 型流感病毒 Ag A 型流感病毒抗原 Ag FLUA Ag FLUA 抗原 FLUAV Ag FLUAV 抗原 FLUV;Influ;列性感冒病毒;流行性感冒病毒 Up 上呼吸道标本;Upper respiratory specimen;呼吸道.上段 上的 上边 上边的 上部 上部的 上部的（Upper，Up） 上面 上面的 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 呼吸道标本（样品、样本）;呼吸系统标本（样品、样本） 在上面 在上面的 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 快速免疫测定;快速免疫测定法;快速免疫分析法;快速免疫检定法;快速免疫检定;快速免疫试验;酶免疫测定法.快速;快速酶免疫测定法;快速酶免疫测定;快速酶免疫分析法;快速酶免疫检定法;快速酶免疫检定;快速酶免疫试验 时刻;随机;随意;瞬间 流感病毒 A 型 Ag 流感病毒甲型 Ag 流感病毒甲型抗原 甲型流感病毒 Ag 甲型流感病毒抗原 较高 较高的

80383-3 Influenza virus B Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

Term Description

This term was created for, but is not limited in use to, the Influenza B part of the bioMerieux bioNexia Influenza A+B test, which is intended for the qualitative detection and differentiation of Influenza type A and type B antigens in human nasopharyngeal samples. The results of the bioNexia assay should be read ten minutes after the sample is applied to the sample well.
Source: Regenstrief LOINC

Part Descriptions

LP14240-3   Influenza virus B
Influenza virus from the family Orthomyxoviridae are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C viruses are medically relevant to humans. Influenza A and B viruses have a similar structure whereby these viruses each contain eight discrete single-stranded RNA gene segments, each encoding at least one protein. While having a close phylogenetic relationship, influenza virus types A and B manifest very differently. While IAV infects birds, humans and other mammals, influenza B only infects humans and seals. Although both viruses cause human respiratory infection seasonally in temperate climate regions and more continually in the tropics, influenza B is normally less prevalent and causes less severe disease than IAV viruses. Research is ongoing to determine the evolutionary and epidemiological factors that shape the genetic diversity of influenza B virus. PMID: 25812763 [CDC:flu/about/viruses/types] Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus B Ag
Property
PrThr
Time
Pt
System
Respiratory.upper
Scale
Ord
Method
IA.rapid

Additional Names

Short Name
FLUBV Ag Upper resp Ql IA.rapid
Display Name
FLUBV Ag IA.rapid Ql (Upper resp)
Consumer Name Alpha Get Info
Influenza B (Flu B) antigen, Upper respiratory

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.73
Change Reason
Release 2.70: SYSTEM: Updated from "Nph" to make the LOINC term consistent with the original intent to represent a manufacturer's test covering NPH washes and nose swabs, as well as to make it consistent across panel usage.; Previous Releases: Corrected System from "Nasopharynx", which is used for LOINC clinical terms, to "Nph", which is the form used for LOINC lab terms.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
1305

Example Answer List LL744-4

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Member of these Panels

LOINC Long Common Name
80381-7 Influenza virus A and B Ag panel - Upper respiratory specimen by Rapid immunoassay
97099-6 Influenza virus A and B and SARS-CoV-2 (COVID-19) Ag panel - Upper respiratory specimen by Rapid immunoassay
95942-9 Influenza virus A and B and SARS-CoV+SARS-CoV-2 (COVID-19) Ag panel - Upper respiratory specimen by Rapid immunoassay

Member of these Groups Get Info

LOINC Group Group Name
LG32757-3 Influenza virus
LG34023-8 Influenza virus B Ag|PrThr|Sys:ANYResp

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Influenza-Virus B Ag:Nachweis oder Schwellenwert:Zeitpunkt:Respirationstrakt.oberer:Ordinal:Immunoassay.schnell
es-MX Spanish (Mexico) Virus de la influenza B Ag:Presencia o umbral:Punto temporal:Nasofaringe:Ordinal:Inmunoensayo rápido
es-ES Spanish (Spain) Virus Influenza B Antígeno:PrThr:Punto temporal:Muestra respiratoria de vías altas:Ord:IA.rapid
Synonyms: Muestra del tracto respiratorio superior Muestra respiratoria Muestra respiratoria superior
fr-FR French (France) Influenza virus B Ag:Présence/Seuil:Ponctuel:Voies respiratoires supérieures:Qualitatif:Immunoanalyse rapide
it-IT Italian (Italy) Influenza B, virus , Ag:PrThr:Pt:Sistema respiratorio.superiore:Ord:IA.rapido
Synonyms: Campione apparato respiratorio superiore Immunoassay Immunoassay rapido Microbiologia Presenza o Soglia Punto nel tempo (episodio) Virus dell''influenza Virus dell''influenza B
nl-NL Dutch (Netherlands) Influenzavirus B Ag:aanwezigheid:moment:bovenste luchtwegen:ordinaal:immunoassay.sneltest
Synonyms: antigeen bovenste ademhalingsstelsel; systema respiratorium superior IA IA.rapid systema respiratorium; ademhalingsstelsel
pl-PL Polish (Poland) Influenza wirus B Ag:granica wykrywalności:punkt w czasie:próbka z górnych dróg oddechowych:półilościowy:szybka metoda immunologiczna
Synonyms: Antygen B Antygen wirusa grypy typu B Wirus grypy Wirus grypy typu B
zh-CN Chinese (China) 流感病毒 B 型 抗原:存在情况或阈值:时间点:呼吸道.上:序数型:免疫测定法.快速
Synonyms: Ag B 型 B 型抗原 B 型流感;B 型流感病毒;FLUB;FLUBV;乙型流感;乙型流感病毒;流感 B;流感 B 型;流感乙型;流感病毒乙型 B 型流感病毒 Ag B 型流感病毒抗原 FLUB Ag FLUB 抗原 FLUBV Ag FLUBV 抗原 FLUV;Influ;列性感冒病毒;流行性感冒病毒 Up 上呼吸道标本;Upper respiratory specimen;呼吸道.上段 上的 上边 上边的 上部 上部的 上部的（Upper，Up） 上面 上面的 乙型流感病毒 Ag 乙型流感病毒抗原 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 呼吸道标本（样品、样本）;呼吸系统标本（样品、样本） 在上面 在上面的 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 快速免疫测定;快速免疫测定法;快速免疫分析法;快速免疫检定法;快速免疫检定;快速免疫试验;酶免疫测定法.快速;快速酶免疫测定法;快速酶免疫测定;快速酶免疫分析法;快速酶免疫检定法;快速酶免疫检定;快速酶免疫试验 时刻;随机;随意;瞬间 流感病毒 B 型 Ag 流感病毒乙型 Ag 流感病毒乙型抗原 较高 较高的

95209-3 SARS-CoV+SARS-CoV-2 (COVID-19) Ag [Presence] in Respiratory system specimen by Rapid immunoassay

Term Description

Qualitative detection of SARS coronavirus (SARS-CoV, also known as SARS-CoV-1) and SARS coronavirus 2 (SARS-CoV-2) antigens in respiratory specimens by rapid immunoassay methods. The test detects but does not differentiate between SARS-CoV and SARS-CoV-2. This term was created for, but is not limited in use to, the submitter's Quidel Sofia 2 SARS Antigen FIA test kit.
Source: Regenstrief LOINC

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright © 2021 Lab Tests Online. All rights reserved. Coronavirus (COVID-19) Testing

Fully-Specified Name

Component
SARS coronavirus+SARS coronavirus 2 Ag
Property
PrThr
Time
Pt
System
Respiratory System Specimen
Scale
Ord
Method
IA.rapid

Additional Names

Short Name
SARS-CoV+SARS-CoV-2 Ag Resp Ql IA.rapid
Display Name
SARS-CoV+SARS-CoV-2 (COVID-19) Ag IA.rapid Ql (Respiratory system specimen)
Consumer Name Alpha Get Info
SARS-CoV+SARS-CoV-2 (COVID-19) antigen, Respiratory system specimen

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.75
Change Reason
Release 2.75: SYSTEM: There are 2 similar system's in LOINC: 1- Respiratory system 2- Respiratory specimen Due to an applied logic, the display in the System axis for 1 is Respiratory (adjective) without specification of sample, specimen, or other specific noun, while 2 is displayed fully as Respiratory specimen. Therefore for now we replaced 1 with Respiratory system specimen, which will affect 83 term. The result is replacing "Respiratory" with "Respiratory system specimen". This is the short approach. The bigger project is to potentially merge data that has either 1 or 2 together. This is a project to pass by the laboratory committee and will involve about 1500 concepts.;
Order vs. Observation
Both
Common Test Rank Get Info
781

Example Answer List LL2021-5

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Invalid Copyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value) LA15841-2

Member of these Panels

LOINC Long Common Name
95942-9 Influenza virus A and B and SARS-CoV+SARS-CoV-2 (COVID-19) Ag panel - Upper respiratory specimen by Rapid immunoassay

Member of these Groups Get Info

LOINC Group Group Name
LG51029-3 SARS coronavirus

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) SARS-Coronavirus+SARS-Coronavirus 2 Ag:Nachweis oder Schwellenwert:Zeitpunkt:Respirationstrakt:Ordinal:Immunoassay.schnell
es-MX Spanish (Mexico) SARS-CoV + SARS-CoV-2 (COVID-19) Ag:Presencia o umbral:Punto temporal:Espécimen respiratorio:Ordinal:Inmunoensayo rápido
es-ES Spanish (Spain) SARS-CoV + SARS-CoV-2 (COVID-19) Antígeno:PrThr:Punto temporal:Muestra del sistema respiratorio:Ord:IA.rapid
Synonyms: Muestra del tracto respiratorio Muestra respiratoria Tracto respiratorio
fr-FR French (France) Coronavirus SARS+coronavirus SARS-CoV-2 Ag:Présence/Seuil:Ponctuel:Spécimen du système respiratoire:Qualitatif:Immunoanalyse rapide
it-IT Italian (Italy) SARS coronavirus+SARS coronavirus 2 , Ag:PrThr:Pt:Campione da Sistema Respiratorio:Ord:IA.rapido
Synonyms: Campione da Apparato Respiratorio Coronavirus della SARS Immunoassay Immunoassay rapido Microbiologia Presenza o Soglia Punto nel tempo (episodio) SARS-CoV+SARS-CoV-2 (COVID-19) SARS-CoV-2 (COVID-19)
nl-NL Dutch (Netherlands) SARS coronavirus + SARS-CoV-2 Ag:aanwezigheid:moment:ademhalingsstelsel:ordinaal:immunoassay.sneltest
Synonyms: antigeen IA IA.rapid SARS-virus severe acute respiratory syndrome coronavirus 2; 2019-nCoV; 2019 novel coronavirus; COVID-19 systema respiratorium; ademhalingsstelsel