80382-5 Influenza virus A Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

Term Description

This term was created for, but is not limited in use to, the Influenza A part of the bioMerieux bioNexia Influenza A+B test, which is intended for the qualitative detection and differentiation of Influenza type A and type B antigens in human nasopharyngeal samples. The results of the bioNexia assay should be read ten minutes after the sample is applied to the sample well.

Part Descriptions

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. PMID: 20542248 ] PMID: 25812763
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component

Influenza virus A Ag

Property

PrThr

Time

Pt

System

Respiratory system specimen.upper

Scale

Ord

Method

IA.rapid

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.54

Last Updated

Version 2.77 (MAJ)

Change Reason

Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC; Release 2.70: SYSTEM: Updated from "Nph" to make the LOINC term consistent with the original intent to represent a manufacturer's test covering NPH washes and nose swabs, as well as to make it consistent across panel usage.; Previous Releases: Corrected System from "Nasopharynx", which is used for LOINC clinical terms, to "Nph", which is the form used for LOINC lab terms.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Common Test Rank Get Info

1303

Example Answer List LL744-4

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Antigen
• Antigens
• Avian influenza
• Bird flu
• Breathing
• EIA
• ELFA
• ELISA
• Enzyme immunoassay
• FLUA
• FLUAV
• FLUV
• Fowl plague
• IAA
• ID
• Infectious Disease
• InfectiousDisease
• Influ
• Influenza A
• Influenza A virus
• Lungs
• MEIA
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• RS
• Screen
• Spec
• SUDS
• Up
• Upper resp

80383-3 Influenza virus B Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

Term Description

This term was created for, but is not limited in use to, the Influenza B part of the bioMerieux bioNexia Influenza A+B test, which is intended for the qualitative detection and differentiation of Influenza type A and type B antigens in human nasopharyngeal samples. The results of the bioNexia assay should be read ten minutes after the sample is applied to the sample well.

Part Descriptions

LP14240-3   Influenza virus B
Influenza virus from the family Orthomyxoviridae are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C viruses are medically relevant to humans. Influenza A and B viruses have a similar structure whereby these viruses each contain eight discrete single-stranded RNA gene segments, each encoding at least one protein. While having a close phylogenetic relationship, influenza virus types A and B manifest very differently. While IAV infects birds, humans and other mammals, influenza B only infects humans and seals. Although both viruses cause human respiratory infection seasonally in temperate climate regions and more continually in the tropics, influenza B is normally less prevalent and causes less severe disease than IAV viruses. Research is ongoing to determine the evolutionary and epidemiological factors that shape the genetic diversity of influenza B virus. PMID: 25812763 [CDC:flu/about/viruses/types] Source: Regenstrief LOINC

Fully-Specified Name

Component

Influenza virus B Ag

Property

PrThr

Time

Pt

System

Respiratory system specimen.upper

Scale

Ord

Method

IA.rapid

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.54

Last Updated

Version 2.77 (MAJ)

Change Reason

Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC; Release 2.70: SYSTEM: Updated from "Nph" to make the LOINC term consistent with the original intent to represent a manufacturer's test covering NPH washes and nose swabs, as well as to make it consistent across panel usage.; Previous Releases: Corrected System from "Nasopharynx", which is used for LOINC clinical terms, to "Nph", which is the form used for LOINC lab terms.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Common Test Rank Get Info

1305

Example Answer List LL744-4

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Antigen
• Antigens
• Breathing
• EIA
• ELFA
• ELISA
• Enzyme immunoassay
• FLUB
• FLUBV
• FLUV
• IAA
• ID
• Infectious Disease
• InfectiousDisease
• Influ
• Influenza B
• Influenza B virus
• Lungs
• MEIA
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• RS
• Screen
• Spec
• SUDS
• Up
• Upper resp

95209-3 SARS-CoV+SARS-CoV-2 (COVID-19) Ag [Presence] in Respiratory system specimen by Rapid immunoassay

Term Description

Qualitative detection of SARS coronavirus (SARS-CoV, also known as SARS-CoV-1) and SARS coronavirus 2 (SARS-CoV-2) antigens in respiratory specimens by rapid immunoassay methods. The test detects but does not differentiate between SARS-CoV and SARS-CoV-2. This term was created for, but is not limited in use to, the submitter's Quidel Sofia 2 SARS Antigen FIA test kit.

Reference Information

Fully-Specified Name

Component

SARS coronavirus+SARS coronavirus 2 Ag

Property

PrThr

Time

Pt

System

Respiratory System Specimen

Scale

Ord

Method

IA.rapid

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.68

Last Updated

Version 2.75 (MAJ)

Change Reason

Release 2.75: SYSTEM: There are 2 similar system's in LOINC: 1- Respiratory system 2- Respiratory specimen Due to an applied logic, the display in the System axis for 1 is Respiratory (adjective) without specification of sample, specimen, or other specific noun, while 2 is displayed fully as Respiratory specimen. Therefore for now we replaced 1 with Respiratory system specimen, which will affect 83 term. The result is replacing "Respiratory" with "Respiratory system specimen". This is the short approach. The bigger project is to potentially merge data that has either 1 or 2 together. This is a project to pass by the laboratory committee and will involve about 1500 concepts.;

Order vs. Observation

Both

Common Test Rank Get Info

781

Example Answer List LL2021-5

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• 2019 Novel Coronavirus
• 2019-nCoV
• Antigen
• Antigens
• Breathing
• Corona virus
• COVID19
• COVID-19
• EIA
• ELFA
• ELISA
• Enzyme immunoassay
• IAA
• ID
• II
• Infectious Disease
• InfectiousDisease
• Lungs
• MEIA
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• RS
• SARS Coronavirus 1
• SARS-CoV
• SARS-CoV+SARS-CoV-2
• SARS-CoV+SARS-CoV-2 Ag
• SARS-CoV-1
• SARS-CoV-2
• Screen
• Severe Acute Respiratory Syndrome
• Spec
• SUDS
• Viral Pneumonias
• Wuhan coronavirus

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.