96603-6

SARS-CoV-2 (COVID-19) S protein RBD neutralizing antibody [Presence] in Serum or Plasma by sVNT

Active

Term Description

Qualitative results for detection of neutralizing antibodies (NAbs) that block the binding of the S (spike) protein receptor binding domain (RDB) from SARS Coronavirus 2 (SARS-CoV-2) to ACE2 receptor protein in serum or plasma specimens by surrogate virus neutralization testing (sVNT), which is an immunoassay-based method. Neutralizing antibody testing is performed to determine whether the antibodies produced after SARS-CoV-2 infection or in response to a vaccination are able to neutralize the virus and prevent infection or re-infection. Different methods can be used to determine the presence of neutralizing antibodies, including conventional VNT (virus neutralization test, cVNT), pseudovirus VNT (pVNT), and surrogate VNT (sVNT). The sVNT method currently employs purified proteins in an immunoassay-based format, takes less time to complete, and does not require the use of live virus compared to cVNT and pVNT methods.
Source: Regenstrief LOINC

Part Description

LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

Reference Information

Type	Source	Reference
Webcontent	Lab Tests Online^®Copyright Copyright © 2021 Lab Tests Online. All rights reserved.	Coronavirus (COVID-19) Testing

Fully-Specified Name

Component: SARS coronavirus 2 spike protein RBD Ab.neut
Property: PrThr
Time: Pt
System: Ser/Plas
Scale: Ord
Method: sVNT

Additional Names

Short Name: SARS-CoV-2 S RBD NAb SerPl Ql sVNT
Display Name: SARS-CoV-2 (COVID-19) S protein RBD neut ab sVNT Ql
Consumer Name Alpha Get Info: SARS-CoV-2 (COVID-19) S protein RBD neutralizing antibody, Blood

Example Answer List: LL2009-0

Source: ARUP Laboratories

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6
EquivocalCopyright http://snomed.info/sct ID:42425007 Equivocal (qualifier value)			LA11885-3

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.69
Last Updated: Version 2.72
Change Reason: Release 2.72: METHOD_TYP: Updated to further specify the type of neutralization assay method used.;
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG51018-6	SARSCoV2 antibody detection

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	SARS Coronavirus 2-Spike-Protein RBD Ak.neutralisierend:Nachweis oder Schwellenwert:Zeitpunkt:Serum oder Plasma:Ordinal:Surrogat-Virus-Neutralisationstest Synonyms: sVNT
es-ES	Spanish (Spain)	Dominio de unión al recepto r(RBD) de la proteína de la espícula del SARS-CoV-2 (COVID-19) Anticuerpos antineutrófilos:PrThr:Punto temporal:Suero o Plasma:Ord:Prueba de neutralización vírica sustitutiva (sVNT)
es-MX	Spanish (Mexico)	Pico de proteína del coronavirus 2 del SARS RBD Ab.neut:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Inmunoensayo
fr-FR	French (France)	Coronavirus SARS-CoV-2 protéine spike RDB Ac neutralisant:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Neutralisation du virus de substitution
it-IT	Italian (Italy)	SARS coronavirus 2, proteina spike RBD Ab.Neut:PrThr:Pt:Siero/Plasma:Ord:sVNT Synonyms: anticorpo Coronavirus della SARS Microbiologia Plasma Presenza o Soglia Proteina spike di SARS-CoV-2 (COVID-19) Proteina spike dominio che lega il recettore (RBD) di SARS Cov-2 (COVID-19) Punto nel tempo (episodio) SARS-CoV-2 (COVID-19) Siero Siero o Plasma Test di neutrolizzazione del virus surrogato (sVNT)
nl-NL	Dutch (Netherlands)	SARS-CoV-2 'spike'-eiwit RBD As.neutraliserend:aanwezigheid:moment:serum of plasma:ordinaal:neutralisatietest met surrogaatvirus (sVNT) Synonyms: antistof; antilichaam SARS-virus severe acute respiratory syndrome coronavirus 2; 2019-nCoV; 2019 novel coronavirus; COVID-19 sVNT
zh-CN	Chinese (China)	SARS 冠状病毒 2 刺突蛋白 RBD 抗体.中和:存在情况或阈值:时间点:血清/血浆:序数型:替代病毒中和试验 Synonyms: 2019 新型冠状病毒;2019 年新型冠状病毒;2019-nCoV;SARS-CoV-2;新型冠状病毒肺炎;新冠肺炎;Coronavirus disease 2019;COVID-19;冠状病毒疾病2019;严重急性呼吸综合征;severe acute respiratory syndrome;SARS;传染性非典型肺炎;infectious atypical pneumonia;非典 Ⅱ Ab;自身抗体 II PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 SARS 冠状病毒 2 刺突蛋白（棘突蛋白、棘刺蛋白） RBD;2019 新型冠状病毒;2019 年新型冠状病毒;2019-nCoV;SARS-CoV-2;新型冠状病毒肺炎;新冠肺炎;Coronavirus disease 2019;COVID-19;冠状病毒疾病2019;严重急性呼吸综合征;severe acute respiratory syndrome;SARS;传染性非典型肺炎;infectious atypical pneumonia;非典 SARS 冠状病毒 2 刺突蛋白（棘突蛋白、棘刺蛋白）;2019 新型冠状病毒;2019 年新型冠状病毒;2019-nCoV;SARS-CoV-2;新型冠状病毒肺炎;新冠肺炎;Coronavirus disease 2019;COVID-19;冠状病毒疾病2019;严重急性呼吸综合征;severe acute respiratory syndrome;SARS;传染性非典型肺炎;infectious atypical pneumonia;非典 SARS;SARS 病毒;SARS-CoV;严重急性呼吸综合征;严重急性呼吸综合征病毒;萨斯病毒;非典;非典型肺炎;非典型肺炎病毒;非典病毒 Surrogate virus neutralization test;sVNT;sVNT法;替代病毒中和试验法中和试验;中和抗体;中和依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）时刻;随机;随意;瞬间血清或血浆

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