75756-7 Bacteria identified in Isolate by MS.MALDI-TOF

Term Description

Bacterial identification by MALDI-TOF (matrix-assisted laser desorption ionization time of flight) is a diagnostic test for identifying the specific organism(s) responsible for a bacterial infection. MALDI-TOF is a form of mass spectrometry that analyzes the proteins contained in an isolated bacterial colony. The resulting mass spectrum is compared to a reference database of bacterial protein mass spectra in order to identify the organism(s) present in the test sample. This term was created for, but is not limited in use to, the Bruker Daltonics MALDI Biotyper CA System, which is indicated for use in diagnosing Gram-negative bacterial infections.
Source: Regenstrief LOINC

Part Descriptions

LP14082-9   Bacteria
One of the three domains of life (the others being Eukarya and Archaea), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls and multiply by cell division. They exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to oxygen (aerobic, anaerobic, or facultatively anaerobic) and by how they obtain their energy (chemotrophic, i.e. via a chemical reaction or phototrophic, via a light reaction). In addition, chemotrophs obtain their energy from chemicals, lithotrophic from inorganic compounds and organotrophic from organic compounds. Bacteria are also classified by the source carbon that they utilize: heterotrophic, from organic sources or autotrophic, from carbon dioxide. They can also be classified by whether or not they stain (based on the structure of their cell walls) with crystal violet dye: gram-negative or gram-positive. Source: National Library of Medicine, MeSH 2006

LP186074-3   MS.MALDI-TOF
Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) is a type of mass spectrometry (MS). MALDI-TOF MS consists of three primary steps: 1) mixing the sample with an organic matrix, which provides a scaffolding and also protons for the ionization process; 2) applying a laser to the matrix, which absorbs energy from the laser and releases it into the sample, which causes the sample to desorb and form singly charged ions; and 3) using a flight tube to analyze the mass of the ions, ultimately resulting in a mass spectrum in which the mass-to-charge is plotted against signal intensity. MALDI-TOF is a soft ionization technique, meaning that molecules remain relatively intact during ionization. Because of this property, MALDI-TOF can be used for protein analysis; in contrast, older MS techniques cause extensive protein fragmentation and therefore cannot be used for this purpose. One application of MALDI-TOF is in clinical microbiology; compared to traditional methods, MALDI-TOF is faster and more accurate in identifying specific microorganisms. PMID: 23824373 Source: Regenstrief LOINC, PMID: 23824373

Fully-Specified Name

Component

Bacteria

Property

Prid

Time

Pt

System

Isolate

Scale

Nom

Method

MS.MALDI-TOF

Additional Names

Short Name

Bacteria Islt MS.MALDI-TOF

Display Name

Bacteria identified MS.MALDI-TOF Nom (Isol)

Consumer Name Alpha Get Info

Bacterial test

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.50

Last Updated

Version 2.78

Change Reason

Release 2.78: COMPONENT: Removed "Identified" from the component because it is implied by the Property "Prid";

Order vs. Observation

Both

Common Test Rank Get Info

13359

Example Answer List LL2991-9

Member of these Panels

Language Variants Get Info

Related Names

• Bact
• ID
• Identity or presence
• Infectious Disease
• InfectiousDisease
• Islt
• Isol
• Microbiology
• Nominal
• Point in time
• Random

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

86930-5 Carbapenemase [Presence] in Isolate

Term Description

The detection of carbapenemase-producing isolates by various phenotypic methods, including the Modified Hodge Test (MHT) and Carbapemenase Inactivation Method (CIM). In MHT, carbapenemase production is detected when the test isolate produces the enzyme and allows growth of a carbapenem susceptible strain (E.coli ATCC 25922) towards a carbapenem disk. The result is a characteristic cloverleaf-like indentation. For CIM, a disk containing the indicator antibiotic meropenem is incubated for 2 hours in a bacterial suspension of the isolate. When the isolate produces carbapenemase, the meropenem in the disk is inactivated allowing uninhibited growth of an indicator strain. PMID: 28476242
Source: Regenstrief LOINC

Part Descriptions

LP105133-5   Carbapenemase
Carbapenems are famously stable to AmpC β-lactamases and extended-spectrum-β-lactamases. Carbapenemases are a diverse group of β-lactamases that are active not only against the oxyimino-cephalosporins and cephamycins but also against the carbapenems. Carbapenemases were formerly believed to derive only from classes A, B, and D, but a class C carbapenemase has been described. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Carbapenemase

Fully-Specified Name

Component

Carbapenemase

Property

PrThr

Time

Pt

System

Isolate

Scale

Ord

Method

Additional Names

Short Name

Carbapenemase Islt Ql

Display Name

Carbapenemase Ql (Isol)

Consumer Name Alpha Get Info

Carbapenemase

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.63

Last Updated

Version 2.63

Order vs. Observation

Both

Example Answer List LL956-4

Member of these Panels

Language Variants Get Info

Related Names

• carbapenem-resistant Klebsiella pneumoniae
• CRE
• CRKP
• Hodge test
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Isol
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

35802-8 Ertapenem [Susceptibility]

Part Descriptions

LP33356-4   Ertapenem
Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz. It is structurally very similar to meropenem in that it possess a 1-β-methyl group. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Ertapenem

Fully-Specified Name

Component

Ertapenem

Property

Susc

Time

Pt

System

Isolate

Scale

OrdQn

Method

Additional Names

Short Name

Ertapenem Susc Islt

Display Name

Ertapenem [Susc]

Consumer Name Alpha Get Info

Susceptibility to Ertapenem

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.13

Last Updated

Version 2.73

Order vs. Observation

Observation

Common Test Rank Get Info

1763

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• AST
• ID
• Infectious Disease
• InfectiousDisease
• InVanz
• Islt
• Isol
• Point in time
• Random
• Sus
• Suscept
• Susceptibilities
• Susceptibility
• Susceptibilty

35801-0 Ertapenem [Susceptibility] by Minimum inhibitory concentration (MIC)

Part Descriptions

LP33356-4   Ertapenem
Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz. It is structurally very similar to meropenem in that it possess a 1-β-methyl group. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Ertapenem

Fully-Specified Name

Component

Ertapenem

Property

Susc

Time

Pt

System

Isolate

Scale

OrdQn

Method

MIC

Additional Names

Short Name

Ertapenem Islt MIC

Display Name

Ertapenem MIC [Susc]

Consumer Name Alpha Get Info

Susceptibility to Ertapenem

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.13

Last Updated

Version 2.73

Order vs. Observation

Observation

Common Test Rank Get Info

1090

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• AST
• ID
• Infectious Disease
• InfectiousDisease
• InVanz
• Islt
• Isol
• Minimum inhibitory concentration
• Point in time
• Random
• Sus
• Suscept
• Susceptibilities
• Susceptibility
• Susceptibilty

6652-2 Meropenem [Susceptibility] by Minimum inhibitory concentration (MIC)

Part Descriptions

LP17167-5   Meropenem
Meropenem is an ultra-broad spectrum antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup carbapenem. Meropenem was developed by Sumitomo Pharmaceuticals. It is marketed outside Japan by AstraZeneca under the brand names Merrem® and Meronem®. Unlike imipenem, it is not affected by the renal dehydrogenase and can therefore be given without cilastatin. It penetrates into the cerebrospinal fluid. Meropenem is less likely to cause seizures compared to imipenem. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Meropenem (Wikipedia)

Reference Information

Fully-Specified Name

Component

Meropenem

Property

Susc

Time

Pt

System

Isolate

Scale

OrdQn

Method

MIC

Additional Names

Short Name

Meropenem Islt MIC

Display Name

Meropenem MIC [Susc]

Consumer Name Alpha Get Info

Susceptibility to Meropenem

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 1.0g

Last Updated

Version 2.73

Order vs. Observation

Observation

Common Test Rank Get Info

820

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• AST
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Isol
• Meronem
• Merrem
• Minimum inhibitory concentration
• Point in time
• Random
• Sus
• Suscept
• Susceptibilities
• Susceptibility
• Susceptibilty

18943-1 Meropenem [Susceptibility]

Part Descriptions

LP17167-5   Meropenem
Meropenem is an ultra-broad spectrum antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup carbapenem. Meropenem was developed by Sumitomo Pharmaceuticals. It is marketed outside Japan by AstraZeneca under the brand names Merrem® and Meronem®. Unlike imipenem, it is not affected by the renal dehydrogenase and can therefore be given without cilastatin. It penetrates into the cerebrospinal fluid. Meropenem is less likely to cause seizures compared to imipenem. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Meropenem (Wikipedia)

Fully-Specified Name

Component

Meropenem

Property

Susc

Time

Pt

System

Isolate

Scale

OrdQn

Method

Additional Names

Short Name

Meropenem Susc Islt

Display Name

Meropenem [Susc]

Consumer Name Alpha Get Info

Susceptibility to Meropenem

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 1.0l

Last Updated

Version 2.73

Order vs. Observation

Observation

Common Test Rank Get Info

1721

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• AST
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Isol
• Meronem
• Merrem
• Point in time
• Random
• Sus
• Suscept
• Susceptibilities
• Susceptibility
• Susceptibilty

7029-2 Meropenem [Susceptibility] by Gradient strip

Part Descriptions

LP17167-5   Meropenem
Meropenem is an ultra-broad spectrum antibiotic used to treat a wide variety of infections, including meningitis and pneumonia. It is a beta-lactam and belongs to the subgroup carbapenem. Meropenem was developed by Sumitomo Pharmaceuticals. It is marketed outside Japan by AstraZeneca under the brand names Merrem® and Meronem®. Unlike imipenem, it is not affected by the renal dehydrogenase and can therefore be given without cilastatin. It penetrates into the cerebrospinal fluid. Meropenem is less likely to cause seizures compared to imipenem. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Meropenem (Wikipedia)

LP6300-0   Gradient strip
A gradient strip is a reagent strip that contains a predefined concentration gradient of a specific antibiotic or combination of antibiotics that is used for antimicrobial susceptibility testing (AST) and antimicrobial resistance detection (ARD).
For AST, the result is reported in terms of the minimum inhibitory concentration (MIC) of a specific antimicrobial that prevents the visible growth of bacteria. In LOINC, the "Gradient strip" method is used for AST gradient strips that result in an MIC result.
For ARD, the result is reported as the presence or absence of a specific enzyme or other mechanism that confers resistance, which is determined based on comparing the inhibitory concentration (IC) of a specific antimicrobial with the IC of that antimicrobial plus a resistance inhibitor. In LOINC, the "Gradient strip ARD" method is used for ARD gradient strips, which are not intended for determining individual MIC values. Source: Regenstrief LOINC

Fully-Specified Name

Component

Meropenem

Property

Susc

Time

Pt

System

Isolate

Scale

OrdQn

Method

Gradient strip

Additional Names

Short Name

Meropenem Islt Grad strip

Display Name

Meropenem Strip [Susc]

Consumer Name Alpha Get Info

Susceptibility to Meropenem

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 1.0h(2)

Last Updated

Version 2.73

Change Reason

Feb 2016-removed "E-test" from the short and long names because the "ETEST" name is trademarked

Order vs. Observation

Observation

Common Test Rank Get Info

6847

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• AST
• Epsilometer
• Estrip
• E-strip
• Grad strip
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Isol
• Meronem
• Merrem
• MIC
• Minimum inhibitory concentration
• Point in time
• Random
• Sus
• Suscept
• Susceptibilities
• Susceptibility
• Susceptibilty

88892-5 Meropenem+Vaborbactam [Susceptibility]

Part Descriptions

LP247822-2   Meropenem+Vaborbactam
Vaborbactam is a beta-lactamase inhibitor in the new cyclic boronic acid class of inhibitors that is being developed in combination with meropenem. It has activity against serine carbapenemases, especially Klebsiella pneumonia carbapenemase (KPC), and the meropenem-vaborbactam combination is effective against KPC-producing strains of Enterobacteriaceae. It has been studied as a treatment of complicated urinary tract infection, acute pyelonephritis, and other infections due to carbapenem-resistant Enterobacteriaceae, including hospital-acquired and ventilator-associated pneumonia PMID: 27527080 In August 2017, meropenem-vaborbactam was approved by the U.S. FDA for the treatment of complicated urinary tract infections, including pyelonephritis. Source: Regenstrief LOINC

Fully-Specified Name

Component

Meropenem+Vaborbactam

Property

Susc

Time

Pt

System

Isolate

Scale

OrdQn

Method

Additional Names

Short Name

Mero+Vab Susc Islt

Display Name

Meropenem+Vaborbactam [Susc]

Consumer Name Alpha Get Info

Susceptibility to Meropenem+Vaborbactam

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.64

Last Updated

Version 2.64

Order vs. Observation

Both

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• AST
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Isol
• Klebsiella pneumonia carbapenemase
• KPC
• Mero+Vab
• Meronem
• Merrem
• Point in time
• Random
• Sus
• Suscept
• Susceptibilities
• Susceptibility
• Susceptibilty
• Vabomere

85427-3 Meropenem+Vaborbactam [Susceptibility] by Minimum inhibitory concentration (MIC)

Part Descriptions

LP247822-2   Meropenem+Vaborbactam
Vaborbactam is a beta-lactamase inhibitor in the new cyclic boronic acid class of inhibitors that is being developed in combination with meropenem. It has activity against serine carbapenemases, especially Klebsiella pneumonia carbapenemase (KPC), and the meropenem-vaborbactam combination is effective against KPC-producing strains of Enterobacteriaceae. It has been studied as a treatment of complicated urinary tract infection, acute pyelonephritis, and other infections due to carbapenem-resistant Enterobacteriaceae, including hospital-acquired and ventilator-associated pneumonia PMID: 27527080 In August 2017, meropenem-vaborbactam was approved by the U.S. FDA for the treatment of complicated urinary tract infections, including pyelonephritis. Source: Regenstrief LOINC

Fully-Specified Name

Component

Meropenem+Vaborbactam

Property

Susc

Time

Pt

System

Isolate

Scale

OrdQn

Method

MIC

Additional Names

Short Name

Mero+Vab Islt MIC

Display Name

Meropenem+Vaborbactam MIC [Susc]

Consumer Name Alpha Get Info

Susceptibility to Meropenem+Vaborbactam

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.61

Order vs. Observation

Both

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• AST
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Isol
• Klebsiella pneumonia carbapenemase
• KPC
• Mero+Vab
• Meronem
• Merrem
• Minimum inhibitory concentration
• Point in time
• Random
• Sus
• Suscept
• Susceptibilities
• Susceptibility
• Susceptibilty
• Vabomere

42357-4 Tigecycline [Susceptibility]

Part Descriptions

LP36048-4   Tigecycline
Tiglylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine Tiglylglycine is an intermediate product of the catabolism of isoleucine. An elevated level of tiglylglycine is identified in urine of patients with beta-ketothiolase deficiency or with disorders of propionate metabolism PMID: 7923765. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Tiglylglycine

LP36048-4   Tigecycline
Tigecycline (INN) is a glycylcycline antibiotic marketed under the brand name Tygacil. It was given a U.S. Food and Drug Administration (FDA) fast-track approval and was approved on June 17, 2005. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus and Acinetobacter baumannii. The New Delhi metallo-β-Lactamase multidrug-resistant Enterobacteriaceae has also shown susceptibility to tigecycline. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component

Tigecycline

Property

Susc

Time

Pt

System

Isolate

Scale

OrdQn

Method

Additional Names

Short Name

Tigecycline Susc Islt

Display Name

Tigecycline [Susc]

Consumer Name Alpha Get Info

Susceptibility to Tigecycline

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.16

Last Updated

Version 2.73

Order vs. Observation

Observation

Common Test Rank Get Info

2026

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• AST
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Isol
• Point in time
• Random
• Sus
• Suscept
• Susceptibilities
• Susceptibility
• Susceptibilty
• Tygacil
• Tygecycline

42355-8 Tigecycline [Susceptibility] by Minimum inhibitory concentration (MIC)

Part Descriptions

LP36048-4   Tigecycline
Tiglylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine Tiglylglycine is an intermediate product of the catabolism of isoleucine. An elevated level of tiglylglycine is identified in urine of patients with beta-ketothiolase deficiency or with disorders of propionate metabolism PMID: 7923765. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Tiglylglycine

LP36048-4   Tigecycline
Tigecycline (INN) is a glycylcycline antibiotic marketed under the brand name Tygacil. It was given a U.S. Food and Drug Administration (FDA) fast-track approval and was approved on June 17, 2005. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus and Acinetobacter baumannii. The New Delhi metallo-β-Lactamase multidrug-resistant Enterobacteriaceae has also shown susceptibility to tigecycline. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component

Tigecycline

Property

Susc

Time

Pt

System

Isolate

Scale

OrdQn

Method

MIC

Additional Names

Short Name

Tigecycline Islt MIC

Display Name

Tigecycline MIC [Susc]

Consumer Name Alpha Get Info

Susceptibility to Tigecycline

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.16

Last Updated

Version 2.73

Order vs. Observation

Observation

Common Test Rank Get Info

907

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• AST
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Isol
• Minimum inhibitory concentration
• Point in time
• Random
• Sus
• Suscept
• Susceptibilities
• Susceptibility
• Susceptibilty
• Tygacil
• Tygecycline

85502-3 Carbapenemase resistance genes panel by Molecular genetics method

Term Description

This panel contains results for the detection of carbapenemase resistance genes, including carbapenemase, ESBL and ampC types, using molecular methods. The panel is performed on either clinically relevant specimens or isolates.
Source: Regenstrief LOINC

Part Descriptions

LP247693-7   Bacterial carbapenem resistance genes panel
Carbapenems are broad-spectrum agents frequently used in treatment of infections caused by gram-negative bacteria that are resistant to multiple drugs. In recent years, Enterobacteriaceae that are resistant to carbapenems (i.e., carbapenem-resistant Enterobacteriaceae or CREs) have emerged, causing serious concern due to the increasingly limited treatment options. Gene testing to determine the type(s) of carbapenemase resistance present helps with determining an appropriate treatment plan. PMID: 26407326 Source: Regenstrief LOINC

Fully-Specified Name

Component

Bacterial carbapenem resistance genes panel

Property

-

Time

Pt

System

Isolate/Specimen

Scale

-

Method

Molgen

Additional Names

Short Name

BCR gene pnl Islt/Spm

Display Name

Carbapenemase resistance genes panel Molgen (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenemase resistance genes panel

Basic Attributes

Class

PANEL.ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.69

Change Reason

Updated System from "Anorectal/Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Order

Panel Type

Panel

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• BCR gene pnl
• Carbapenemase
• CPR
• CPR genes
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Pan
• PANEL.ANTIBIOTIC SUSCEPTIBILITIES
• Panl
• PCR
• Pnl
• Point in time
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Spec

85823-3 Carbapenem resistance blaGES gene [Presence] by Molecular method

Term Description

This test reports the presence of the GES carbapenemase gene in gram negative bacterial isolates. This term was created for, but is not limited in use to, the submitter's modified protocol for the Check-Points Check-MDR CT103XL assay.
Source: Regenstrief LOINC

Part Descriptions

LP248287-7   Bacterial carbapenem resistance blaGES gene
Extended-spectrum beta-lactamases (ESBL) are enzymes produced by some gram negative bacilli that confer resistance to the majority of beta-lactam antibiotics, include the penicillins, cephalosporins and the monobactam aztreonam. ESBLs are most often plasmid-borne. Specific ESBLs include TEM, SHV, and the CTX-M groups, which are the most clinically prevalent, and VEB, PER, BEL, and GES, which are less common. PMID: 19246801 -TEM and SHV subtypes are derived from amino acid substitutions, resulting in enzymatic hydrolysis of many beta-lactam antibiotics. -CTX-M genes originate from Kluyvera species. They are separated based on their amino acid sequences into the following groups: CTX-M-1, CTX-M-2, CTX-M-9, CTX-M-8, and CTX-M-25. -VEB, PER, BEL, and GES genes are less common. [Mayo Medical Laboratories] The nomenclature for ESBL genes includes the prefix "bla", which stands for "beta-lactam", followed by the enzyme (ie. blaTEM). Source: Regenstrief LOINC

Fully-Specified Name

Component

Bacterial carbapenem resistance blaGES gene

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaGES Islt/Spm Ql

Display Name

Carbapenem resistance blaGES gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaGES gene

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.67

Change Reason

Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Observation

Example Answer List LL360-9

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Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• CPR
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

85833-2 Carbapenem resistance blaGIM gene [Presence] by Molecular method

Term Description

This test reports the presence of the GIM bacterial carbapenemase resistance type gene in gram negative bacterial isolates. This term was created for, but is not limited in use to, the submitter's modified protocol for the Check-Points Check-MDR CT103XL assay.
Source: Regenstrief LOINC

Part Descriptions

LP248234-9   Bacterial carbapenem resistance blaGIM gene
The Ambler classification for carbapenemases utilizes four molecular classes - A, B, C and D. The GIM enzymes identified in Pseudomonas spp. are included in class B. The clinical revelance of of the GIM enzymes is that they can act as reservoires and carriers of the causal factor of resistance. The growing prevalence of carbapenemase-producing organisms reveals the importance of optimizing the detection while minimizing the dissemination of these types of strains.
PMID: 20172419 Source: Regenstrief LOINC

Fully-Specified Name

Component

Bacterial carbapenem resistance blaGIM gene

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaGIM Islt/Spm Ql

Display Name

Carbapenem resistance blaGIM gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaGIM gene

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.67

Change Reason

Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Observation

Example Answer List LL360-9

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• CPR
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

85498-4 Carbapenem resistance blaIMP gene [Presence] by Molecular method

Term Description

This term is used to report the carbapenemase resistance bla(IMP) gene, detected in various specimens, including rectal swabs and isolates. It was created for, but is not limited in use to, the GeneXpert Carba-R test kit.
Source: Regenstrief LOINC

Part Descriptions

LP248294-3   Bacterial carbapenem resistance blaIMP gene
Plasmid-mediated IMP-type carbapenemases are currently known to have 17 varieties. Studies have revealed its establishment in Japan in the 1990s in enteric Gram-negative organisms, Pseudomonas species and Acinetobacter species. IMP genes usually co-exist with other resistance genes resulting in multi-drug resistance.
Studies have shown that a high percentage of patients with immunodeficiency and drug resistant nosocomial infections are infected with a VIM or IMP producing organism, particularly when the organism identified is pseudomonas aeruginosa. The two genes are often present together although they can also be present individually. Identifying the presence of these genes is important in monitoring drug resistance and determining the best antibiotic therapy methods.
PMID: 27563634 PMID: 28085553 Source: Regenstrief LOINC

Fully-Specified Name

Component

Bacterial carbapenem resistance blaIMP gene

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaIMP Islt/Spm Ql

Display Name

Carbapenem resistance blaIMP gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaIMP gene

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.73

Change Reason

Updated System from "Anorectal/Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Observation

Common Test Rank Get Info

4988

Example Answer List LL956-4

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• CPR
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

95540-1 Carbapenem resistance blaIMP+blaVIM genes [Presence] by Molecular method

Fully-Specified Name

Component

Bacterial carbapenem resistance blaIMP+blaVIM genes

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaIMP+blaVIM Islt/Spm Ql

Display Name

Carbapenem resistance blaIMP+blaVIM genes Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaIMP+blaVIM genes

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.69

Last Updated

Version 2.69

Order vs. Observation

Both

Example Answer List LL744-4

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• CPR
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

49617-4 Carbapenem resistance blaKPC gene [Presence] by Molecular method

Part Descriptions

LP64707-0   Bacterial carbapenem resistance blaKPC gene
Non-susceptibility to carbapenems in gram-negative bacilli by means of the enzyme KPC (Klebsiella pneumoniae carbapenemase) is becoming more common. The gene beta-lactamase KPC (bla(KPC)) encodes KPC enzyme production, which in turn hydrolyzes and inactivates carbapenem antibiotics. KPC enzymes are a class A beta lactamases with several variants (KPC-2, KPC-3, etc) known. Various methods are used to detect specific portions of genes encoding KPC production. Carbapenemases can also be detected by other methods, including the modified Hodge test to detect carbapenemase production in isolates and minimum inhibitory concentration (MIC) to determine level of resistance. Source: Regenstrief LOINC

Fully-Specified Name

Component

Bacterial carbapenem resistance blaKPC gene

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaKPC Islt/Spm Ql

Display Name

Carbapenem resistance blaKPC gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaKPC gene

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.22

Last Updated

Version 2.73

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Corrected Component from "Bacterial carbapenemase resistance" to "Bacterial carbapenem resistance" (because the bacteria are resistant to carbapenem antibiotics by virtue of producing carbapenemase) and removed parentheses around and within the gene name according to recommended nomenclature [PMID: 25249841]; Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Both

Common Test Rank Get Info

1861

Example Answer List LL360-9

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• Carbapenem resistance gene
• CPR
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

73982-1 Carbapenem resistance blaNDM gene [Presence] by Molecular method

Term Description

Detection of bla(NDM) genotypes by molecular-based assays in isolates positive for gram-negative bacilli. Test is performed to determine resistance to carbapenems due to NDM (New Dehli metallo-β-lactamase) enzyme production.
Source: Regenstrief LOINC

Part Descriptions

LP173523-4   Bacterial carbapenem resistance blaNDM gene
New Delhi Metallo-beta-lactamase (NDM) is an enzyme that makes bacteria resistant to a broad range of beta-lactam antibiotics, including those in the carbapenem family. NDM-1 presents as the most dominant type. The NDM gene encodes beta-lactamase enzymes called carbapenemases. The most common bacteria that make the NDM enzyme are Gram-negative such as Escherichia coli and Klebsiella pneumoniae, but the gene for NDM can spread from one strain of bacteria to another by horizontal gene transfer. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, NDM beta lactamases

Fully-Specified Name

Component

Bacterial carbapenem resistance blaNDM gene

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaNDM Islt/Spm Ql

Display Name

Carbapenem resistance blaNDM gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaNDM gene

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.46

Last Updated

Version 2.73

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Corrected Component from "Bacterial carbapenemase resistance" to "Bacterial carbapenem resistance" (because the bacteria are resistant to carbapenem antibiotics by virtue of producing carbapenemase) and removed parentheses around and within the gene name according to recommended nomenclature [PMID: 25249841]; Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Both

Common Test Rank Get Info

4995

Example Answer List LL360-9

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• CPR
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

86712-7 Carbapenem resistance blaOXA gene [Presence] by Molecular method

Part Descriptions

LP185703-8   Bacterial carbapenem resistance blaOXA gene
Oxacillinases, or OXA beta-lactamases, are Class D plasmid-mediated beta-lactamases that hydrolyze oxacillin and related anti-staphylococcal penicillins. Amino acid substitutions in OXA enzymes can also give the extended-spectrum beta-lactamase (ESBL) phenotype. While most ESBLs have been found in E. coli, K. pneumoniae, and other Enterobacteriaceae, the OXA-type ESBLs have been found mainly in P. aeruginosa. The bla(OXA) gene is one of several beta-lactam antibiotic resistance gene markers. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, OXA beta lactamases

Fully-Specified Name

Component

Bacterial carbapenem resistance blaOXA gene

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaOXA Islt/Spm Ql

Display Name

Carbapenem resistance blaOXA gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaOXA gene

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.73

Change Reason

Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Both

Common Test Rank Get Info

4997

Example Answer List LL744-4

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• CPR
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

85825-8 Carbapenem resistance blaOXA-23-like gene [Presence] by Molecular method

Term Description

This test reports the presence of the OXA-23-like bacterial carbapenemase resistance type gene in gram negative bacterial isolates. This term was created for, but is not limited in use to, the submitter's modified protocol for the Check-Points Check-MDR CT103XL assay.
Source: Regenstrief LOINC

Part Descriptions

LP248243-0   Bacterial carbapenem resistance blaOXA-23-like gene
The Ambler classification for carbapenemases utilizes four molecular classes - A, B, C and D. The OXA group of β-lactamases occur mainly in Acinetobacter species and are part of molecular class D. The "OXA-like" groups of genes are molecularly similar to and thought to evolve from the original gene for which the group is named. For example, as of 2014 the blaOXA-23-like group included 19 genes, including including blaOXA-23, -27, -49, and -73. PMID: 24696435. Many OXA enzymes (OXA-23-like, OXA-24-like, OXA-48-like, OXA-58-like) are considered to be responsible for the worldwide resistance epidemics. OXA-23-like enzymes have been isolated in carbapenem-resistant Acinetobacter baumannii (CR-AB) in both the US and in China, revealing the importance of national and global efforts to control the spread of CR-AB.
PMID: 24629777 PMID: 26617588 Source: Regenstrief LOINC

Fully-Specified Name

Component

Bacterial carbapenem resistance blaOXA-23-like gene

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaOXA-23-like Islt/Spm Ql

Display Name

Carbapenem resistance blaOXA-23-like gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaOXA-23-like gene

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.67

Change Reason

Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Observation

Example Answer List LL360-9

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• CPR
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

93390-3 Carbapenem resistance blaOXA-23-like+blaOXA-48-like genes [Presence] in Isolate or Specimen by Molecular method

Term Description

This test detects but does not differentiate between the OXA-23 and OXA-48 groups, which both confer carbapenem resistance. This term was created for, but not limited in use to, the blaOXA antimicrobial resistant marker result in GeneMark's ePlex Blood Culture Identification Gram-Negative Panel.
Source: Regenstrief LOINC

Part Descriptions

LP411469-2   Bacterial carbapenem resistance blaOXA-23-like+blaOXA-48-like genes
The Ambler classification for carbapenemases utilizes four molecular classes - A, B, C and D. The OXA group of β-lactamases occur mainly in Acinetobacter species and are part of molecular class D. The "OXA-like" groups of genes are molecularly similar to and thought to evolve from the original gene for which the group is named. For example, as of 2014 the blaOXA-23-like group included 19 genes, including including blaOXA-23, -27, -49, and -73. PMID: 24696435. Many OXA enzymes (OXA-23-like, OXA-24-like, OXA-48-like, OXA-58-like) are considered to be responsible for the worldwide resistance epidemics. OXA-23-like enzymes have been isolated in carbapenem-resistant Acinetobacter baumannii (CR-AB) in both the US and in China, revealing the importance of national and global efforts to control the spread of CR-AB.
PMID: 24629777 PMID: 26617588 Source: Regenstrief LOINC

Fully-Specified Name

Component

Bacterial carbapenem resistance blaOXA-23-like+blaOXA-48-like genes

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaOXA-23+48-like genes Islt/Spm Ql

Display Name

Carbapenem resistance blaOXA-24-like+blaOXA-48-like genes Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaOXA-24-like+blaOXA-48-like genes

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.67

Last Updated

Version 2.70

Order vs. Observation

Observation

Example Answer List LL744-4

Member of these Panels

Language Variants Get Info

Related Names

• Bact
• blaOXA-24+48-like
• CPR
• Islt
• Islt/Spm
• Isol
• Microbiology
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

85826-6 Carbapenem resistance blaOXA-24-like gene [Presence] by Molecular method

Term Description

This test reports the presence of the OXA-24-like bacterial carbapenemase resistance type gene in gram negative bacterial isolates. This term was created for, but is not limited in use to, the submitter's modified protocol for the Check-Points Check-MDR CT103XL assay.
Source: Regenstrief LOINC

Part Descriptions

LP248290-1   Bacterial carbapenem resistance blaOXA-24-like gene
The Ambler classification for carbapenemases utilizes four molecular classes - A, B, C and D. The OXA group of β-lactamases occur mainly in Acinetobacter species and are part of molecular class D. The "OXA-like" groups of genes are molecularly similar to and thought to evolve from the original gene for which the group is named. For example, as of 2014 the blaOXA-23-like group included 19 genes, including including blaOXA-23, -27, -49, and -73. PMID: 24696435. Many OXA enzymes (OXA-23-like, OXA-24-like, OXA-48-like, OXA-58-like) are considered to be responsible for the worldwide resistance epidemics. OXA-23-like enzymes have been isolated in carbapenem-resistant Acinetobacter baumannii (CR-AB) in both the US and in China, revealing the importance of national and global efforts to control the spread of CR-AB.
PMID: 24629777 PMID: 26617588 Source: Regenstrief LOINC

Fully-Specified Name

Component

Bacterial carbapenem resistance blaOXA-24-like gene

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaOXA-24-like Islt/Spm Ql

Display Name

Carbapenem resistance blaOXA-24-like gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaOXA-24-like gene

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.67

Change Reason

Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Observation

Example Answer List LL360-9

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• CPR
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

85503-1 Carbapenem resistance blaOXA-48 gene [Presence] by Molecular method

Term Description

This term is used to report the carbapenemase resistance blaOBX-48 gene, detected in various specimens, including rectal swabs and isolates.
Source: Regenstrief LOINC

Part Descriptions

LP248468-3   Bacterial carbapenem resistance blaOXA-48 gene
The OXA-48 gene encodes one of the three primary classes of beta-lactamase produced by Enterobacteriaceae. OXA-48 is mainly harbored in Klebsiella pneumoniae and occurs mainly in North Africa and Turkey. It has been identified in both nosocomial and community-acquired infections. PMID: 24930781 OXA-48 is a member of the OXA group of class D beta-lactamases which includes six subgroups that are able to hydrolyze carbapenem in different degrees and of which OXA-48 is a member. PMID: 24696435 Carbapenems are the most effective treatment against bacteria that produce ESBLs. PMID: 18495062 Source: Regenstrief LOINC

Fully-Specified Name

Component

Bacterial carbapenem resistance blaOXA-48 gene

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaOXA-48 Islt/Spm Ql

Display Name

Carbapenem resistance blaOXA-48 gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance blaOXA-48 gene

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.69

Change Reason

Updated System from "Anorectal/Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Observation

Example Answer List LL956-4

Member of these Panels

Language Variants Get Info

Related Names

• ANTIBIOTIC SUSCEPTIBILITIES
• Bact
• CPR
• ID
• Infectious Disease
• InfectiousDisease
• Islt
• Islt/Spm
• Isol
• Molecular genetics
• Ordinal
• PCR
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Resist
• Resistanc
• Resistant
• Resistent
• Screen
• Spec

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

85827-4 Carbapenem resistance bla OXA-48-like gene [Presence] by Molecular method

Term Description

This test reports the presence of the OXA-48-like bacterial carbapenemase resistance type gene in gram negative bacterial isolates. This term was created for, but is not limited in use to, the submitter's modified protocol for the Check-Points Check-MDR CT103XL assay.
Source: Regenstrief LOINC

Part Descriptions

LP248274-5   Bacterial carbapenem resistance blaOXA-48-like gene
The existence of OXA-48 like class D beta-lactamases has been increasing in enterobacter species organisms. The "OXA-like" groups of genes are molecularly similar to and thought to evolve from the original gene for which the group is named. For example, as of 2014 the blaOXA-23-like group included 19 genes, including including blaOXA-23, -27, -49, and -73. PMID: 24696435. The OXA-48 like class D beta-lactamase enzymes are highly resistant to penicillins and beta lactamase inhibitors and show a low resistance to carbapenems. These varied OXA-48-like beta-lactamases have been identified worldwide, including OXA-48-like producing Klebsiella pneumoniae with resistance to multiple drugs that emerged in Jordanian hospitals. Reports have shown that organisms producing OXA-48 like enzymes are either not resistant to broad-spectrum cephalosporins or show a decreased susceptibility to carbapenemase drugs. Identifying them can be a challenge. Screening and detection is required to prevent and control dissemination. PMID: 22499996 PMID: 26993738 Source: Regenstrief LOINC

Fully-Specified Name

Component

Bacterial carbapenem resistance blaOXA-48-like gene

Property

PrThr

Time

Pt

System

Isolate/Specimen

Scale

Ord

Method

Molgen

Additional Names

Short Name

blaOXA-48-like Islt/Spm Ql

Display Name

Carbapenem resistance bla OXA-48-like gene Molgen Ql (Islt/Spec)

Consumer Name Alpha Get Info

Carbapenem resistance bla OXA-48-like gene

Basic Attributes

Class

ABXBACT

Type

Laboratory

First Released

Version 2.61

Last Updated

Version 2.67

Change Reason

Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].

Order vs. Observation

Observation

Example Answer List LL360-9

Member of these Panels