97561-5
Necrotizing myopathy autoimmune Ab panel - Serum
Active
95726-6 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab [Units/volume] in Serum or Plasma by Immunoassay
Part Descriptions
LP220363-8 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase (HMG-CoA reductase or HMGCR) is an enzyme in the cholesterol-synthesis pathway and is the target of HMG-CoA reductase inhibitors, also known as statins. Autoantibodies to HMGCR may be a marker of necrotizing autoimmune myopathy (NAM), which is characterized by muscle fiber necrosis with little or no inflammation and responsiveness to immunosuppressive treatment. Anti-HMGCR positive cases of NAM usually have limited extramuscular involvement, slow onset of muscle disease, and can occur in both adults and children. Due to the insidious onset, pediatric cases of NAM may be initially confused with muscular dystrophy. The anti-HMGCR antibody titer may correlate with muscle strength and creatine kinase level. Some cases of NAM have been diagnosed in patients previously exposed to statins, and in some of these cases, stopping the statin drug was the only intervention necessary for the resolution of disease. However, exposure to statins is not required to diagnose cases of NAM, and first-line treatment typically includes corticosteroids or other immunosuppressive drugs such as methotrexate. PMID: 24797170
Source: Regenstrief LOINC, PMID: 24797170
Fully-Specified Name
- Component
- 3-Hydroxy-3-Methylglutaryl-Coenzyme A reductase Ab
- Property
- ACnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
- IA
Additional Names
- Short Name
- HMGCR Ab SerPl IA-aCnc
- Display Name
- 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab IA Qn
- Consumer Name Alpha Get Info
- 3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.69
- Last Updated
- Version 2.69
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 97561-5 | Necrotizing myopathy autoimmune Ab panel - Serum |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG51037-6 | 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | 3-hidroxi-3-metilglutaril-coenzima A reductasa Ab: |
| es-ES | Spanish (Spain) | 3-Hidroxy-3-metilglutaril-CoA reductasa Anticuerpos: Synonyms: Cuantitativo |
| fr-FR | French (France) | 3-hydroxy-3-méthylglutaryl-coenzyme A réductase anticorps: |
| it-IT | Italian (Italy) | 3-idrossi-3-metilglutaril-coenzima A reduttasi Ab: Synonyms: anticorpo Concentrazione Arbitraria Immunoassay Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | 3-hydroxy-3-methylglutaryl-CoA-reductase As: Synonyms: antistof; |
| zh-CN | Chinese (China) | 3-羟基-3-甲基戊二酰-辅酶 A 还原酶 抗体: Synonyms: 3-羟基-3-甲基戊二酰基-辅酶 A 还原酶; |
Example Units
| Unit | Source |
|---|---|
| [IU]/L | Example UCUM Units |
93493-5 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase IgG Ab [Units/volume] in Serum by Immunoassay
Part Descriptions
LP230274-5 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab.IgG
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase (HMG-CoA reductase or HMGCR) is an enzyme in the cholesterol-synthesis pathway and is the target of HMG-CoA reductase inhibitors, also known as statins. Autoantibodies to HMGCR may be a marker of necrotizing autoimmune myopathy (NAM), which is characterized by muscle fiber necrosis with little or no inflammation and responsiveness to immunosuppressive treatment. Anti-HMGCR positive cases of NAM usually have limited extramuscular involvement, slow onset of muscle disease, and can occur in both adults and children. Due to the insidious onset, pediatric cases of NAM may be initially confused with muscular dystrophy. The anti-HMGCR antibody titer may correlate with muscle strength and creatine kinase level. Some cases of NAM have been diagnosed in patients previously exposed to statins, and in some of these cases, stopping the statin drug was the only intervention necessary for the resolution of disease. However, exposure to statins is not required to diagnose cases of NAM, and first-line treatment typically includes corticosteroids or other immunosuppressive drugs such as methotrexate. PMID: 24797170
Source: Regenstrief LOINC, PMID: 24797170
Fully-Specified Name
- Component
- 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Ab.IgG
- Property
- ACnc
- Time
- Pt
- System
- Ser
- Scale
- Qn
- Method
- IA
Additional Names
- Short Name
- HMGCR IgG Ser IA-aCnc
- Display Name
- 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase IgG IA Qn (S)
- Consumer Name Alpha Get Info
- 3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase IgG antibody, Blood
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.67
- Last Updated
- Version 2.67
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 97561-5 | Necrotizing myopathy autoimmune Ab panel - Serum |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | 3-hidroxi-3-metilglutaril-coenzima A reductasa Ab.IgG: |
| es-ES | Spanish (Spain) | 3-Hidroxy-3-metilglutaril-CoA reductasa IgG: Synonyms: Cuantitativo |
| fr-FR | French (France) | 3-hydroxy-3-méthylglutaryl-coenzyme A réductase anticorps IgG: |
| it-IT | Italian (Italy) | 3-idrossi-3-metilglutaril-coenzima A reduttasi Ab.IgG: Synonyms: anticorpi IgG anticorpo Chimica Concentrazione Arbitraria Immunoassay Punto nel tempo (episodio) Siero |
| nl-NL | Dutch (Netherlands) | 3-hydroxy-3-methylglutaryl-CoA-reductase As.IgG: Synonyms: antistof; |
| zh-CN | Chinese (China) | 3-羟基-3-甲基戊二酰-辅酶 A 还原酶 抗体.IgG: Synonyms: 3-羟基-3-甲基戊二酰基-辅酶 A 还原酶; |
Example Units
| Unit | Source |
|---|---|
| [IU]/mL | Example UCUM Units |
53010-5 Signal Recognition Particle (SRP) Ab [Presence] in Serum or Plasma by Immunofluorescence
Part Descriptions
LP31710-4 Signal recognition particle
A cytosolic ribonucleoprotein complex that acts to induce elongation arrest of nascent presecretory and membrane proteins until the ribosome becomes associated with the rough endoplasmic reticulum. It consists of a 7S RNA and at least six polypeptide subunits (relative molecular masses 9, 14, 19, 54, 68, and 72K).
Source: National Library of Medicine, MeSH 2006
LP39745-2 Signal recognition particle Ab
Anti-signal recognition particle antibodies are mainly associated with, but are not very specific for, polymyositis. For individuals with polymyositis, the presence of anti-SRP antibodies are associated with more prominent muscle weakness and atrophy.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
Fully-Specified Name
- Component
- Signal recognition particle Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser/Plas
- Scale
- Ord
- Method
- IF
Additional Names
- Short Name
- SRP Ab SerPl Ql IF
- Display Name
- Signal Recognition Particle (SRP) Ab IF Ql
- Consumer Name Alpha Get Info
- Signal Recognition Particle (SRP) antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.24
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Example Answer List LL360-9
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 97561-5 | Necrotizing myopathy autoimmune Ab panel - Serum |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG14565-2 | Signal recognition particle Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: SRP-AK ql.IF |
| de-DE | German (Germany) | Signalerkennungspartikel Ak: Synonyms: SRP |
| es-ES | Spanish (Spain) | Particula de reconocimiento de señal (SRP) Anticuerpos: |
| es-MX | Spanish (Mexico) | Partícula de reconocimiento de señal Ab: |
| fr-CA | French (Canada) | Particule reconnaissance signal, Ac: |
| fr-FR | French (France) | SRP anticorps: |
| fr-BE | French (Belgium) | Particule reconnaissance signal Ac: Synonyms: Anticorps |
| it-IT | Italian (Italy) | Particella di riconoscimento del segnale Ab: Synonyms: anticorpo Immunofluorescenza (IF) Particella di Riconoscimento del Segnale (SRP) Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | signaalherkenningsdeeltje As: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Cząsteczka rozpoznająca sygnał Ab: Synonyms: Cząsteczka rozpoznająca sygnał Przeciwciała do cząsteczek rozpoznających sygnał |
| pt-BR | Portuguese (Brazil) | Sinal de reconhecimento de partículas Ac: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Сигнал распознавание частица Ат: Synonyms: Антитело Иммунофлюоресценция (ИФ) Плазма Порядковый Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Sinyal tanıyıcı partikül Ab: Synonyms: Ak İmmünflorerans Mevcut |
| zh-CN | Chinese (China) | 信号识别颗粒 抗体: Synonyms: Ab; |
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.
53011-3 Signal Recognition Particle (SRP) Ab [Titer] in Serum or Plasma by Immunofluorescence
Part Descriptions
LP31710-4 Signal recognition particle
A cytosolic ribonucleoprotein complex that acts to induce elongation arrest of nascent presecretory and membrane proteins until the ribosome becomes associated with the rough endoplasmic reticulum. It consists of a 7S RNA and at least six polypeptide subunits (relative molecular masses 9, 14, 19, 54, 68, and 72K).
Source: National Library of Medicine, MeSH 2006
LP39745-2 Signal recognition particle Ab
Anti-signal recognition particle antibodies are mainly associated with, but are not very specific for, polymyositis. For individuals with polymyositis, the presence of anti-SRP antibodies are associated with more prominent muscle weakness and atrophy.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
Fully-Specified Name
- Component
- Signal recognition particle Ab
- Property
- Titr
- Time
- Pt
- System
- Ser/Plas
- Scale
- SemiQn
- Method
- IF
Additional Names
- Short Name
- SRP Ab Titr SerPl IF
- Display Name
- Signal Recognition Particle (SRP) Ab IF [Titer]
- Consumer Name Alpha Get Info
- Signal Recognition Particle (SRP) antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.24
- Last Updated
- Version 2.75
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 97561-5 | Necrotizing myopathy autoimmune Ab panel - Serum |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Signalerkennungspartikel Ak: Synonyms: SRP |
| de-AT | German (Austria) | Synonyms: SRP-AK Ti.IF |
| es-MX | Spanish (Mexico) | Partícula de reconocimiento de señal Ab: |
| es-ES | Spanish (Spain) | Particula de reconocimiento de señal (SRP) Anticuerpos: Synonyms: Semicuantitativo |
| fr-CA | French (Canada) | Particule reconnaissance signal, Ac: |
| fr-FR | French (France) | SRP anticorps: |
| it-IT | Italian (Italy) | Particella di riconoscimento del segnale Ab: Synonyms: anticorpo Immunofluorescenza (IF) Particella di Riconoscimento del Segnale (SRP) Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant Titolo |
| nl-NL | Dutch (Netherlands) | signaalherkenningsdeeltje As: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Cząsteczka rozpoznająca sygnał Ab: Synonyms: Cząsteczka rozpoznająca sygnał Przeciwciała do cząsteczek rozpoznających sygnał |
| pt-BR | Portuguese (Brazil) | Sinal de reconhecimento de partículas Ac: Synonyms: ; |
| zh-CN | Chinese (China) | 信号识别颗粒 抗体: Synonyms: Ab; |
Example Units
| Unit | Source |
|---|---|
| {titer} | Example UCUM Units |
82936-6 Signal Recognition Particle (SRP) IgG Ab [Presence] in Serum by Line blot
Term Description
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC
Part Descriptions
LP31710-4 Signal recognition particle
A cytosolic ribonucleoprotein complex that acts to induce elongation arrest of nascent presecretory and membrane proteins until the ribosome becomes associated with the rough endoplasmic reticulum. It consists of a 7S RNA and at least six polypeptide subunits (relative molecular masses 9, 14, 19, 54, 68, and 72K).
Source: National Library of Medicine, MeSH 2006
Fully-Specified Name
- Component
- Signal recognition particle Ab.IgG
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- Line blot
Additional Names
- Short Name
- SRP IgG Ser Ql Line blot
- Display Name
- Signal Recognition Particle (SRP) IgG Line blot Ql (S)
- Consumer Name Alpha Get Info
- Signal Recognition Particle (SRP) IgG antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.66
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
- Both
Example Answer List LL2010-8
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 | ||
| Borderline | LA4259-3 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 97561-5 | Necrotizing myopathy autoimmune Ab panel - Serum |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG51136-6 | Signal recognition particle Ab.IgG| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Partícula de reconocimiento de señal Ab.IgG: |
| es-ES | Spanish (Spain) | Particula de reconocimiento de señal (SRP) IgG: |
| fr-FR | French (France) | SRP anticorps IgG: |
| fr-CA | French (Canada) | Particule reconnaissance signal, IgG: |
| it-IT | Italian (Italy) | Particella di riconoscimento del segnale Ab.IgG: Synonyms: anticorpi IgG anticorpo Particella di Riconoscimento del Segnale (SRP) Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | signaalherkenningsdeeltje As.IgG: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Cząsteczka rozpoznająca sygnał Ab.IgG: Synonyms: Cząsteczka rozpoznająca sygnał IgG Przeciwciała do cząsteczek rozpoznających sygnał Przeciwciała IgG do cząsteczek rozpoznających sygnał |
| zh-CN | Chinese (China) | 信号识别颗粒 抗体.IgG: Synonyms: Ab.IgG; |
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.