98030-0
Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC)
Active
33193-4 Viable cells/100 cells in Blood
Term Description
CAP requirement to perform cell viability test
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Viable cells/100 cells
- Property
- NFr
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Additional Names
- Short Name
- Viable cells NFr Bld
- Display Name
- Viable cells/100 cells (Bld)
- Consumer Name Alpha Get Info
- Viable cells per 100 cells, Blood
Basic Attributes
- Class
- CELLMARK
- Type
- Laboratory
- First Released
- Version 2.09
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 5359
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 69042-0 | Lymphocyte proliferation antigen panel - Blood by Flow cytometry (FC) |
| 69018-0 | Lymphocyte proliferation mitogen panel - Blood by Flow cytometry (FC) |
| 98030-0 | Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC) |
| 99771-8 | SARS coronavirus 2 spike and nucleocapsid protein stimulated gamma interferon panel - Blood |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-AR | Spanish (Argentina) | células viables/100 células: |
| es-MX | Spanish (Mexico) | Células viables / 100 células: |
| es-ES | Spanish (Spain) | Células viables/100 células: Synonyms: Cuantitativo |
| fr-CA | French (Canada) | Cellules viables/100 cellules: |
| fr-FR | French (France) | Cellules viables/100 cellules: |
| fr-BE | French (Belgium) | Cellules viables/100 cellules: |
| it-IT | Italian (Italy) | Cellule vitali/100 cellule: Synonyms: Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue |
| ko-KR | Korean (Korea, Republic Of) | 생 세포/100 세포: |
| nl-NL | Dutch (Netherlands) | levensvatbare cellen/100 cellen: |
| pt-BR | Portuguese (Brazil) | Células viáveis/100 células: Synonyms: Cell integrity; |
| ru-RU | Russian (Russian Federation) | Жизнеспособные клетки/100 клеток: Synonyms: Количественный Количество отношение Кровь Точка во времени; |
| tr-TR | Turkish (Turkey) | Canlı hücreler/100 hücre: |
| zh-CN | Chinese (China) | 活细胞/100 个细胞: Synonyms: 可用数量表示的; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
| % | REGENSTRIEF |
90242-9 Natural killer cell cytotoxicity.IL-stimulated 0.9:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP268101-5 Natural killer cell cytotoxicity.IL-2 stimulated 0.9:1 effector to target cell ratio
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.IL-2 stimulated 0.9:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Additional Names
- Short Name
- NK cyto IL2 0.9:1 E:T/Pos cntrl Bld MC
- Display Name
- NK cytotoxicity.IL-stim 0.9:1 E:T ratio/Positive control (Bld MC) [Rel units/Vol]
- Consumer Name Alpha Get Info
- NK Cytotoxicity.IL-stim 0.9:1 E:T Ratio/Positive Control, Blood
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98030-0 | Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC) |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Citotoxicidad de las células asesinas naturales. Efector estimulado por IL-2 a una proporción de células diana de 0.9: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer estimuladas con IL-2. Proporción efector con célula diana 0.9: Synonyms: Cuantitativo |
| fr-FR | French (France) | Cytotoxicité cellules NK stimulées par IL-2 Patient 0.9/1 %: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità. rapporto IL-2 stimolato 0.9: Synonyms: Cellula natural killer, citotossicità. rapporto IL stimolato 0.9: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.IL-2 刺激型 效应细胞/靶细胞比 0.9: Synonyms: Ⅰ Ⅱ I II 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
90243-7 Natural killer cell cytotoxicity.IL-stimulated 1.88:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP268100-7 Natural killer cell cytotoxicity.IL-2 stimulated 1.88:1 effector to target cell ratio
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.IL-2 stimulated 1.88:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Additional Names
- Short Name
- NK cyto IL2 1.88:1 E:T/Pos cntrl Bld MC
- Display Name
- NK cytotoxicity.IL-stim 1.88:1 E:T ratio/Positive control (Bld MC) [Rel units/Vol]
- Consumer Name Alpha Get Info
- NK Cytotoxicity.IL-stim 1.88:1 E:T Ratio/Positive Control, Blood
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98030-0 | Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC) |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales. Relación efectora / célula diana estimulada por IL-2 1,88: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer estimuladas con IL-2. Proporción efector con célula diana 1.88: Synonyms: Cuantitativo |
| fr-FR | French (France) | Cytotoxicité cellules NK stimulées par IL-2 Patient 1.88/1 %: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità. rapporto IL-2 stimolato 1.88: Synonyms: Cellula natural killer, citotossicità. rapporto IL stimolato 1.88: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.IL-2 刺激型 效应细胞/靶细胞比 1.88: Synonyms: Ⅰ Ⅱ I II 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
90245-2 Natural killer cell cytotoxicity.IL-stimulated 3.75:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP268099-1 Natural killer cell cytotoxicity.IL-2 stimulated 3.75:1 effector to target cell ratio
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.IL-2 stimulated 3.75:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Additional Names
- Short Name
- NK cyto IL2 3.75:1 E:T/Pos cntrl Bld MC
- Display Name
- NK cytotoxicity.IL-stim 3.75:1 E:T ratio/Positive control (Bld MC) [Rel units/Vol]
- Consumer Name Alpha Get Info
- NK Cytotoxicity.IL-stim 3.75:1 E:T Ratio/Positive Control, Blood
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98030-0 | Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC) |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales. Efector estimulado por IL-2 3.75: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer estimuladas con IL-2. Proporción efector con célula diana 3.75: Synonyms: Cuantitativo |
| fr-FR | French (France) | Cytotoxicité cellules NK stimulées par IL-2 Patient 3.75/1 %: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità. rapporto IL-2 stimolato 3.75: Synonyms: Cellula natural killer, citotossicità. rapporto IL stimolato 3.75: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.IL-2 刺激型 效应细胞/靶细胞比 3.75: Synonyms: Ⅰ Ⅱ I II 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
90249-4 Natural killer cell cytotoxicity.IL-stimulated 7.5:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP268098-3 Natural killer cell cytotoxicity.IL-2 stimulated 7.5:1 effector to target cell ratio
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.IL-2 stimulated 7.5:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Additional Names
- Short Name
- NK cyto IL2 7.5:1 E:T/Pos cntrl Bld MC
- Display Name
- NK cytotoxicity.IL-stim 7.5:1 E:T ratio/Positive control (Bld MC) [Rel units/Vol]
- Consumer Name Alpha Get Info
- NK Cytotoxicity.IL-stim 7.5:1 E:T Ratio/Positive Control, Blood
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98030-0 | Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC) |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales. Relación efectora / célula diana estimulada por IL-2 7.5: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer estimuladas con IL-2. Proporción efector con célula diana 7.5: Synonyms: Cuantitativo |
| fr-FR | French (France) | Cytotoxicité cellules NK stimulées par IL-2 Patient 7.5/1 %: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità. rapporto IL-2 stimolato 7.5: Synonyms: Cellula natural killer, citotossicità. rapporto IL stimolato 7.5: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.IL-2 刺激型 效应细胞/靶细胞比 7.5: Synonyms: Ⅰ Ⅱ I II 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
90244-5 Natural killer cell cytotoxicity.IL-stimulated 15:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP268097-5 Natural killer cell cytotoxicity.IL-2 stimulated 15:1 effector to target cell ratio
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.IL-2 stimulated 15:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Additional Names
- Short Name
- NK cyto IL2 15:1 E:T/Pos cntrl Bld MC
- Display Name
- NK cytotoxicity.IL-stim 15:1 E:T ratio/Positive control (Bld MC) [Rel units/Vol]
- Consumer Name Alpha Get Info
- NK Cytotoxicity.IL-stim 15:1 E:T Ratio/Positive Control, Blood
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98030-0 | Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC) |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales Relación efectora / célula diana estimulada por IL-2 15: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer estimuladas con IL-2. Proporción efector con célula diana 15: Synonyms: Cuantitativo |
| fr-FR | French (France) | Cytotoxicité cellules NK stimulées par IL-2 Patient 15/1 %: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità. rapporto IL-2 stimolato 15: Synonyms: Cellula natural killer, citotossicità. rapporto IL stimolato 15: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.IL-2 刺激型 效应细胞/靶细胞比 15: Synonyms: Ⅰ Ⅱ I II 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
90241-1 Natural killer cell cytotoxicity.IL-2 stimulated 30:1 effector to target cell ratio/Positive control in Blood mononuclear cells
Part Descriptions
LP268234-4 Natural killer cell cytotoxicity.IL-2 stimulated 30:1 effector to target cell ratio
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
LP264987-1 Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Natural killer cell cytotoxicity.IL-2 stimulated 30:1 effector to target cell ratio/Positive control
- Property
- RelACnc
- Time
- Pt
- System
- Bld MC
- Scale
- Qn
- Method
Additional Names
- Short Name
- NK cyto IL2 30:1 E:T/Pos cntrl Bld MC
- Display Name
- NK cytotoxicity.IL-2 stim 30:1 E:T ratio/Positive control (Bld MC) [Rel units/Vol]
- Consumer Name Alpha Get Info
- NK Cytotoxicity.IL-2 Stim 30:1 E:T Ratio/Positive Control, Blood
Basic Attributes
- Class
- HEM/BC
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98030-0 | Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC) |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Citotoxicidad de células asesinas naturales Relación efectora / célula diana estimulada por IL-2 30: |
| es-ES | Spanish (Spain) | Citotoxicidad de las células Natural killer estimuladas con IL-2. Proporción efector con célula diana 30: Synonyms: Cuantitativo |
| fr-FR | French (France) | Cytotoxicité cellules NK stimulées par IL-2 Patient 30/1 %: |
| it-IT | Italian (Italy) | Cellula natural killer, citotossicità. rapporto IL-2 stimolato 30: Synonyms: Cellula natural killer, citotossicità. rapporto IL stimolato 30: |
| zh-CN | Chinese (China) | 自然杀伤细胞细胞毒性.IL-2 刺激型 效应细胞/靶细胞比 30: Synonyms: Ⅰ Ⅱ I II 全血（血液、 |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |