Version 2.80

Part Description

LP428152-5   FLT3 gene internal tandem duplication length
The FLT3 gene (fms-related tyrosine kinase 3) [HGNC Gene ID:3765] is located on chromosome 13q12. This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] [NCBI Gene ID:2322] FLT3 mutations occur in approximately 1/3 of patients with AML. About 70% are internal tandem duplications, and the rest are due to variants in the tyrosine kinase domain of FLT3, primarily at Asp835 (D835). PMID: 17124058 Source: Regenstrief LOINC

Fully-Specified Name

Component
FLT3 gene internal tandem duplication length
Property
Num
Time
Pt
System
Bld/Tiss
Scale
Qn
Method
Molgen

Additional Names

Long Common Name
FLT3 gene internal tandem duplication length [#] in Blood or Tissue by Molecular genetics method
Short Name
FLT3 gene ITD length Bld/T
Display Name
FLT3 gene internal tandem dup length Molgen (Bld/Tiss) [#]
Consumer Name Alpha Get Info
FLT3 gene internal tandem Dup length, Blood or tissue specimen

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.71
Last Updated
Version 2.71 (ADD)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Μήκος εσωτερικού διαδοχικού διπλασιασμού γονιδίου FLT3:Αρ.:Pt:Αίμα/Ιστός:Qn:Μοριακή γενετική
Synonyms: Αρ. Γονίδιο Γονίδιο FLT3 Εσωτερικός διαδοχικός διπλασιασμός γονιδίου FLT3 Μήκος Μήκος εσωτερικού διαδοχικού διπλασιασμού γονιδίου FLT3
es-ES Spanish (Spain) Longitud de duplicación interna en tándem del gen FLT3:Número (recuento):Punto temporal:Sangre o tejido:Qn:Genética molecular
Synonyms: Cuantitativo
fr-FR French (France) FLT3 gène longueur ITD:Nombre:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
it-IT Italian (Italy) Doppio gene interno FLT3, duplicazione lunghezza:Num:Pt:Sangue/Tess:Qn:Molgen
Synonyms: Duplicazione lunghezza doppio gene interno FLT3 Gene FLT3 Genetica molecolare Numero (conta) Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) lengte van interne tandemduplicatie op FLT3-gen:aantal:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek
Synonyms: FLT3 gen FLT3 gen interne tandem molgen
zh-CN Chinese (China) FLT3 基因内部串联重复长度:数量(计数):时间点:全血/组织:定量型:分子遗传学类实验室方法
Synonyms: FL 细胞因子受体前体;FLK2;fms-相关性酪氨酸激酶 3;STK1;STK-1;干细胞酪氨酸激酶 1 FLT3 基因内部串联重复（重复突变）长度;FLT3-ITD 长度 FLT3 基因内部串联重复;FLT3 基因内部串联重复突变;FLT3 gene internal tandem duplication;内部串联重复突变;内部串联重复;内部串联突变;internal tandem duplications;ITD 个数;数量;数量或计数（非负整数）;计数 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因 长;长短

Example Units

Unit Source
{bp} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=98489-8