98492-2
Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid
Active
70072-4 Amyloid beta 40 peptide [Mass/volume] in Cerebral spinal fluid
Part Descriptions
LP145733-4 Amyloid beta 40 peptide
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.
The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.
Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Wikipedia
Fully-Specified Name
- Component
- Amyloid beta 40 peptide
- Property
- MCnc
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.40
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 18066
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98492-2 | Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid |
| 106057-3 | Beta-Amyloid 1-42 and 1-40 panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Amyloid-beta-40-Peptid: Synonyms: Zerebrospinalflüssigkeit |
| de-AT | German (Austria) | Synonyms: Amyloid Beta 40 Peptid /L |
| el-GR | Greek (Greece) | β-αμυλοειδές πεπτίδιο 40: Synonyms: MCnc β-αμυλοειδές πεπτίδιο 40 |
| es-ES | Spanish (Spain) | Péptido amiloide beta 40: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Péptido beta 40 amiloide: |
| fr-FR | French (France) | Peptide bêta amyloïde 1-40: |
| it-IT | Italian (Italy) | Amiloide beta 40 peptide: Synonyms: Chimica Concentrazione di Massa Liquido cerebrospinale Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | amyloïd-bèta-40-peptide: Synonyms: amyloid beta 40 peptide |
| pt-BR | Portuguese (Brazil) | Beta amilóide 40 peptídeo: |
| ru-RU | Russian (Russian Federation) | Амилоид бета 40 пептид: Synonyms: Количественный Массовая концентрация Точка во времени; |
| tr-TR | Turkish (Turkey) | Amiloid beta 40 peptid: |
| zh-CN | Chinese (China) | 淀粉样蛋白 Beta 40 肽: Synonyms: B CSF CSF; |
Example Units
| Unit | Source |
|---|---|
| pg/mL | Example UCUM Units |
33203-1 Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid
Part Descriptions
LP30823-6 Amyloid beta 42 peptide
Abeta 42 level is elevated in individuals whose chromosomes carry the genetic mutations characteristic of the early form of Alzheimer's.
Source: Regenstrief Institute
LP30823-6 Amyloid beta 42 peptide
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.
The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.
Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Wikipedia
Fully-Specified Name
- Component
- Amyloid beta 42 peptide
- Property
- MCnc
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.09
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 17504
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98492-2 | Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid |
| 106057-3 | Beta-Amyloid 1-42 and 1-40 panel - Cerebral spinal fluid |
| 104134-2 | Dementia evaluation panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Amyloid-beta-42-Peptid: Synonyms: Zerebrospinalflüssigkeit |
| de-AT | German (Austria) | Synonyms: Amyloid Beta 42 /L |
| el-GR | Greek (Greece) | β-αμυλοειδές πεπτίδιο 42: Synonyms: MCnc β-αμυλοειδές πεπτίδιο 42 |
| es-AR | Spanish (Argentina) | péptido amiloide beta 42: |
| es-ES | Spanish (Spain) | Péptido beta amiloide 42: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Péptido beta 42 amiloide: |
| fr-FR | French (France) | Peptide bêta amyloïde 1-42: |
| fr-BE | French (Belgium) | Peptide amyloïde béta 42: |
| fr-CA | French (Canada) | Peptide amyloïde bêta 42: |
| it-IT | Italian (Italy) | Amiloide beta 42 peptide: Synonyms: Chimica Concentrazione di Massa Liquido cerebrospinale Punto nel tempo (episodio) |
| ko-KR | Korean (Korea, Republic Of) | 아밀로이드 베타 42 펩티드: |
| nl-NL | Dutch (Netherlands) | amyloïd-bèta-42-peptide: Synonyms: amyloid beta 42 peptide |
| pt-BR | Portuguese (Brazil) | Beta amilóide 42 peptídeo: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Амилоид бета 42 пептид: Synonyms: Количественный Массовая концентрация Точка во времени; |
| tr-TR | Turkish (Turkey) | Amiloid beta 42 peptid: |
| zh-CN | Chinese (China) | 淀粉样蛋白 Beta 42 肽: Synonyms: Ab42 peptide; |
Example Units
| Unit | Source |
|---|---|
| pg/mL | Example UCUM Units |
98485-6 Amyloid beta 42 peptide/Amyloid beta 40 peptide [Mass Ratio] in Cerebral spinal fluid
Part Descriptions
LP30823-6 Amyloid beta 42 peptide
Abeta 42 level is elevated in individuals whose chromosomes carry the genetic mutations characteristic of the early form of Alzheimer's.
Source: Regenstrief Institute
LP30823-6 Amyloid beta 42 peptide
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.
The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.
Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Wikipedia
Fully-Specified Name
- Component
- Amyloid beta 42 peptide/Amyloid beta 40 peptide
- Property
- MRto
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.71
- Last Updated
- Version 2.74 (MIN)
- Change Reason
- Release 2.74: ORDER_OBS: Classified as both an order and an observation;
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98492-2 | Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid |
| 106057-3 | Beta-Amyloid 1-42 and 1-40 panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Amyloid-beta-42-Peptid/Amyloid-beta-40-Peptid: Synonyms: Zerebrospinalflüssigkeit |
| de-AT | German (Austria) | Synonyms: Amyloid Beta 42/Amyloid Beta 40 Ratio /L |
| el-GR | Greek (Greece) | β-αμυλοειδές πεπτίδιο 42/β-αμυλοειδές πεπτίδιο 40: Synonyms: MRto β-αμυλοειδές πεπτίδιο 40 β-αμυλοειδές πεπτίδιο 42 |
| es-ES | Spanish (Spain) | Péptido beta amiloide 42/Péptido amiloide beta 40 (Aβ40): Synonyms: Cuantitativo |
| fr-FR | French (France) | Peptide bêta amyloïde 1-42/peptide bêta amyloïde 1-40: |
| it-IT | Italian (Italy) | Amiloide beta 42 peptide/Amiloide beta 40 peptide: Synonyms: Chimica Liquido cerebrospinale Punto nel tempo (episodio) Rapporto di Massa |
| nl-NL | Dutch (Netherlands) | amyloïd-bèta-42-peptide/amyloïd-bèta-40-peptide: Synonyms: amyloid beta 40 peptide amyloid beta 42 peptide |
| zh-CN | Chinese (China) | 淀粉样蛋白 Beta 42 肽/淀粉样蛋白 Beta 40 肽: Synonyms: Ab40 肽; |
Example Units
| Unit | Source |
|---|---|
| pg/pg | Example UCUM Units |
98486-4 Apolipoprotein E [Mass/volume] in Cerebral spinal fluid
Part Descriptions
LP15412-7 Apolipoprotein E
Apolipoproteins are a family of proteins involved in cholesterol transport and metabolism. Apoliprotein E is important in cholesterol transport throughout the body and is encoded by the APOE gene. The three most common forms of apolipoprotein E are E2, E3 and E4, which are encoded by the APOE allele variants e2, e3 (the wild type form) and e4, respectively. The E3 form is responsible for typical cholesterol metabolism. E2 and E4 are associated with alterations in lipid transport and metabolism, and nearly all patients with type III hyperlipoproteinemia (HLP), a familial disorder associated with early atherosclerosis, exclusively make the E2 form of apolipoprotein E. However, 90% of people that only make E2 have cholesterol levels in the normal range, and only about 10% have type III HLP. E4 may also be a marker for Alzheimer's disease. PMID: 11701639
Source: Regenstrief LOINC
, PMID: 11701639
Fully-Specified Name
- Component
- Apolipoprotein E
- Property
- MCnc
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.71
- Last Updated
- Version 2.71 (ADD)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98492-2 | Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Απολιποπρωτεΐνη E: Synonyms: E MCnc Απολιποπρωτεΐνη E |
| es-ES | Spanish (Spain) | Apolipoproteína E: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Apolipoproteiin E: Synonyms: Juhuslik Kvantitatiivne Liikvor |
| fr-BE | French (Belgium) | Apolipoprotéine E: |
| fr-FR | French (France) | Apolipoprotéine E: |
| fr-CA | French (Canada) | Apolipoprotéine E: |
| it-IT | Italian (Italy) | Apolipoproteina E: Synonyms: Chimica Concentrazione di Massa Liquido cerebrospinale Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | apolipoproteïne E: |
| pl-PL | Polish (Poland) | Apolipoproteina E: Synonyms: Apolipoproteina E |
| ru-RU | Russian (Russian Federation) | Аполипопротеин E: Synonyms: Количественный Массовая концентрация Точка во времени; |
| tr-TR | Turkish (Turkey) | Apolipoprotein E: |
| zh-CN | Chinese (China) | 载脂蛋白 E: Synonyms: Apo E; |
Example Units
| Unit | Source |
|---|---|
| ug/mL | Example UCUM Units |
98483-1 Apolipoprotein E phenotype [Identifier] in Cerebral spinal fluid
Fully-Specified Name
- Component
- Apolipoprotein E phenotype
- Property
- Prid
- Time
- Pt
- System
- CSF
- Scale
- Nom
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.71
- Last Updated
- Version 2.71 (ADD)
- Order vs. Observation
- Observation
Example Answer List LL6024-5
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| ApoE phenotype E2/E2 | LA32563-1 | ||
| ApoE phenotype E2/E3 | LA32564-9 | ||
| ApoE phenotype E3/E3 (wild type) | LA32565-6 | ||
| ApoE phenotype E2/E4 | LA32566-4 | ||
| ApoE phenotype E3/E4 | LA32567-2 | ||
| ApoE phenotype E4/E4 | LA32568-0 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98492-2 | Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Φαινότυπος απολιποπρωτεΐνης E: Synonyms: E Prid Απολιποπρωτεΐνη E Φαινότυπος απολιποπρωτεΐνης E |
| es-ES | Spanish (Spain) | Fenotipo apolipoproteína E: |
| fr-BE | French (Belgium) | Phénotypage de l'apolipoprotéine E: |
| fr-FR | French (France) | Apolipoprotéine E phénotype: |
| fr-CA | French (Canada) | Phénotype de l'apolipoprotéine E: |
| it-IT | Italian (Italy) | Apolipoproteina E, fenotipo: Synonyms: Chimica Fenotipo della apolipoproteina E Liquido cerebrospinale Presenza o Identità Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | apolipoproteïne E fenotype: |
| pl-PL | Polish (Poland) | Apolipoproteina E fenotyp: Synonyms: Apolipoproteina E Apolipoproteina E fenotyp |
| ru-RU | Russian (Russian Federation) | Аполипопротеин E фенотипирование: Synonyms: Номинальный; |
| tr-TR | Turkish (Turkey) | Apolipoprotein E fenotipleme: |
| zh-CN | Chinese (China) | 载脂蛋白E表现型分型: Synonyms: Apo E; |
98484-9 Apolipoprotein E phenotype [Interpretation] in Cerebral spinal fluid Narrative
Fully-Specified Name
- Component
- Apolipoprotein E phenotype
- Property
- Imp
- Time
- Pt
- System
- CSF
- Scale
- Nar
- Method
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.71
- Last Updated
- Version 2.71 (ADD)
- Order vs. Observation
- Observation
Example Answer List LL6026-0
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| The E2/E2 combination of ApoE isoforms is considered lower risk with a 0.6 odds ratio for the development of Alzheimer's disease versus the most common combination of ApoE isoforms (E3/E3). | LA32571-4 | ||
| The E2/E3 combination of ApoE isoforms is considered lower risk with a 0.6 odds ratio for the development of Alzheimer's disease versus the most common combination of ApoE isoforms (E3/E3). | LA32572-2 | ||
| The E3/E3 combination of ApoE isoforms is the most common and is considered average risk with a 1.0 odds ratio for the development of Alzheimer's disease. | LA32573-0 | ||
| The E2/E4 combination of ApoE isoforms is considered higher risk with a 2.6 odds ratio for the development of Alzheimer's disease versus the most common combination of ApoE isoforms (E3/E3). | LA32574-8 | ||
| The E3/E4 combination of ApoE isoforms is considered higher risk with a 3.2 odds ratio for the development of Alzheimer's disease versus the most common combination of ApoE isoforms (E3/E3). | LA32575-5 | ||
| The E4/E4 combination of ApoE isoforms is considered high risk with a 14.9 odds ratio for the development of Alzheimer's disease versus the most common combination of ApoE isoforms (E3/E3). | LA32576-3 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98492-2 | Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Φαινότυπος απολιποπρωτεΐνης E: Synonyms: E Imp Απολιποπρωτεΐνη E Φαινότυπος απολιποπρωτεΐνης E |
| es-ES | Spanish (Spain) | Fenotipo apolipoproteína E: |
| fr-BE | French (Belgium) | Phénotypage de l'apolipoprotéine E: |
| fr-FR | French (France) | Apolipoprotéine E phénotype: |
| fr-CA | French (Canada) | Phénotype de l'apolipoprotéine E: |
| it-IT | Italian (Italy) | Apolipoproteina E, fenotipo: Synonyms: Chimica Fenotipo della apolipoproteina E Impressione/interpretazione di studio Liquido cerebrospinale Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | apolipoproteïne E fenotype: |
| ru-RU | Russian (Russian Federation) | Аполипопротеин E фенотипирование: Synonyms: Впечатление/интерпретация исследования Описательный Точка во времени; |
| tr-TR | Turkish (Turkey) | Apolipoprotein E fenotipleme: |
| zh-CN | Chinese (China) | 载脂蛋白E表现型分型: Synonyms: Apo E; |
98487-2 Alzheimer's disease risk [Score] in Cerebral spinal fluid by calculation
Term Description
This score is calculated based on Beta-Amyloid 42, 40, their ratio, and total ApoE in CSF, as well as the ApoE Isoform.
Fully-Specified Name
- Component
- Alzheimer's disease risk
- Property
- Score
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
- Calculated
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.71
- Last Updated
- Version 2.71 (ADD)
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98492-2 | Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Kίνδυνος νόσου Alzheimer: Synonyms: Kίνδυνος νόσου Alzheimer S Βαθμολογία |
| es-ES | Spanish (Spain) | Riesgo de enfermedad de Alzheimer: Synonyms: Cuantitativo |
| fr-FR | French (France) | Risque de maladie d'Alzheimer: |
| it-IT | Italian (Italy) | Malattia di Alzheimer, rischio: Synonyms: Chimica Liquido cerebrospinale Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | risico op Alzheimer-dementie: Synonyms: ziekte van Alzheimer |
| zh-CN | Chinese (China) | 阿尔茨海默病风险: Synonyms: CSF CSF; |
Example Units
| Unit | Source |
|---|---|
| {score} | Example UCUM Units |