99066-3
PL-12 Ab [Units/volume] in Serum by Line blot
Active
Part Description
LP30803-8 PL-12
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes.
Source: Regenstrief LOINC,
PMID: 23573256
LOINC Names Get Info
- Fully-Specified Name
- PL-12 Ab:
ACnc: Pt: Ser: Qn: Line blot - Long Common Name
- PL-12 Ab [Units/volume] in Serum by Line blot
- Short Name
- PL12 Ab Ser Line blot-aCnc
- Display Name
- PL-12 Ab Line blot Qn (S)
- Consumer Name Alpha Get Info
- PL-12 antibody, Blood
Part Model Get Info
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.72
- Last Updated
- Version 2.72 (ADD)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 88883-4 | Connective tissue autoimmune Ab panel - Serum |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG51679-5 | PL-12 Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | PL-12 Ab: |
| el-GR | Greek (Greece) | PL-12 Αντίσωμα: Synonyms: ACnc PL-12 Pt Qn SERO Αντίσωμα Γραμμή κηλίδωσης Ορός |
| es-ES | Spanish (Spain) | Pl-12 Anticuerpos: Synonyms: Cuantitativo |
| fr-CA | French (Canada) | Pl-12, Ac: |
| fr-FR | French (France) | PL-12 Ac: |
| it-IT | Italian (Italy) | PL-12 Ab: Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | PL-12 As: Synonyms: antistof; |
| pl-PL | Polish (Poland) | PL-12 Ab: Synonyms: Alanylo-tRNA syntetaza |
| zh-CN | Chinese (China) | Pl-12 抗体: Synonyms: Ab; |
Example Units
| Unit | Source |
|---|---|
| [arb'U]/mL | Example UCUM Units |
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://