Version 2.80

74117-3 Adalimumab [Mass/volume] in Serum or Plasma

Part Descriptions

LP173592-9   Adalimumab
Adalimumab is a human monoclonal antibody that binds tumor necrosis factor alpha (TNFα). TNFα is a cell signaling protein that, when present in excess, may lead to the development of inflammatory immune diseases including Crohn's disease, rheumatoid arthritis, psoriatic arthritis and inflammatory bowel disease. Adalimumab inactivates TNFα by binding to the TNFα receptor. PMID: 23943614 Treatment with adalimumab does not necessitate laboratory monitoring though association with increased transamines and pancytopenia may argue for intermittant blood cell counts and liver function tests. Adalimumab has been associated with serious infections including the reactivation of tuberculosis and deep fungal infections as well as other rare side effects, including lymphoma, heart failure and demyelinating disease. PMID: 16011443 Source: Regenstrief LOINC

Fully-Specified Name

Component
Adalimumab
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
3133

Member of these Panels

LOINC Long Common Name
99781-7 Adalimumab and Adalimumab Ab panel - Serum or Plasma by Immunoassay

Member of these Groups Get Info

LOINC Group Group Name
LG28982-3 Adalimumab|MCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Adalimumab:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
de-AT German (Austria) Synonyms: Adalimumab
el-GR Greek (Greece) Αδαλιμουμάμπη:MCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: MCnc Αδαλιμουμάμπη
es-MX Spanish (Mexico) Adalimumab:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Adalimumab:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
fr-FR French (France) Adalimumab:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
it-IT Italian (Italy) Adalimumab:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) adalimumab:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Adalimumab::Pt:Soro/Plas:Qn:
ru-RU Russian (Russian Federation) Адалимумаб:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Adalimumab:KütlKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 阿达木单抗:质量浓度:时间点:血清/血浆:定量型:
Synonyms: Adalimumab 单抗;人体抗肿瘤坏死因子-α单克隆抗体;阿达莫单抗;阿达木;阿达莫;阿达木单克隆抗体 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ug/mL Example UCUM Units

74116-5 Adalimumab Ab [Mass/volume] in Serum or Plasma

Term Description

This assay measures the amount of adalimumab antibodies. In the absence of anti-adalimumab antibodies, the adalimumab drug level typically reflects the total adalimumab concentration in serum. In the presence if anti-adalimumab antibodies, the adalimumab level typically reflects the antibody-unbound fraction of adalimumab concentration in serum. At drug levels of 2 ug/mL or higher, anti-adalimumab antibody quantification may be affected. However, even at adalimumab drug levels of 100 ug/mL, positive anti-adalimumab levels remain detectable.

Part Descriptions

LP173592-9   Adalimumab
Adalimumab is a human monoclonal antibody that binds tumor necrosis factor alpha (TNFα). TNFα is a cell signaling protein that, when present in excess, may lead to the development of inflammatory immune diseases including Crohn's disease, rheumatoid arthritis, psoriatic arthritis and inflammatory bowel disease. Adalimumab inactivates TNFα by binding to the TNFα receptor. PMID: 23943614 Treatment with adalimumab does not necessitate laboratory monitoring though association with increased transamines and pancytopenia may argue for intermittant blood cell counts and liver function tests. Adalimumab has been associated with serious infections including the reactivation of tuberculosis and deep fungal infections as well as other rare side effects, including lymphoma, heart failure and demyelinating disease. PMID: 16011443 Source: Regenstrief LOINC

LP173593-7   Adalimumab Ab
Antibodies to adalimumab were shown to develop in 67% of patients within the first 28 weeks of treatment. Only thirteen percent of patients with adalimumab antibodies experienced relief from symptoms compared to 48% of patients without antibodies to adalimumab. Only 4% of patients with antibodies went into remission compared to 34% of patients who achieved remission without anti-adalimumab antibodies. Antibodies to adalimumab reduced the likelihood that patients would have relief from disease symptoms or go into remission. PMID: 21486979 Source: Regenstrief LOINC

Fully-Specified Name

Component
Adalimumab Ab
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
4128

Member of these Panels

LOINC Long Common Name
99781-7 Adalimumab and Adalimumab Ab panel - Serum or Plasma by Immunoassay

Member of these Groups Get Info

LOINC Group Group Name
LG28981-5 Adalimumab Ab|MCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Adalimumab Antikörper
el-GR Greek (Greece) Αδαλιμουμάμπη Αντίσωμα:MCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: MCnc Αδαλιμουμάμπη
es-MX Spanish (Mexico) Adalimumab Ab:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Adalimumab Anticuerpos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
fr-FR French (France) Adalimumab anticorps:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
it-IT Italian (Italy) Adalimumab Ab:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: anticorpo Concentrazione di Massa Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) adalimumab As:massa/volume:moment:serum of plasma:kwantitatief:
Synonyms: antistof; antilichaam
pt-BR Portuguese (Brazil) Adalimumab Ac::Pt:Soro/Plas:Qn:
ru-RU Russian (Russian Federation) Адалимумаб Ат:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Антитело Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Adalimumab Ab:KütlKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 阿达木单抗 抗体:质量浓度:时间点:血清/血浆:定量型:
Synonyms: Ab;自身抗体 Adalimumab 单抗;人体抗肿瘤坏死因子-α单克隆抗体;阿达莫单抗;阿达木;阿达莫;阿达木单克隆抗体 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆

Example Units

Unit Source
ng/mL Example UCUM Units