LP100046-4
Ramelteon M-II
Active
Description
The major metabolite of ramelteon, M-II, is active and has approximately one tenth and one fifth the binding affinity of the parent molecule for the human MT1 and MT2 receptors, respectively, and is 17 - 25-fold less potent than ramelteon in in vitro functional assays. Although the potency of M-II at MT1 and MT2 receptors is lower than the parent drug, M-II circulates at higher concentrations than the parent producing 20 - 100 fold greater mean systemic exposure when compared to ramelteon. M-II has weak affinity for the serotonin 5-HT2B receptor, but no appreciable affinity for other receptors or enzymes. Similar to ramelteon, M-II does not interfere with the activity of a number of endogenous enzymes. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Ramelteon M-II
Basic Part Properties
- Part Display Name
- Ramelteon M-II
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2010-04-07
- Construct for LOINC Short Name
- Ramelteon M-II
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 雷美替胺 M-II Synonyms: 瑞美替昂 M-II; |
| fr-CA | French (Canada) | Ramelteon M-II |
| et-EE | Estonian (Estonia) | Ramelteoon M2 |
| es-ES | Spanish (Spain) | Ramelteon M-II |
| it-IT | Italian (Italy) | Ramelteon M-II |
| tr-TR | Turkish (Turkey) | Ramelteon M-II |
| ru-RU | Russian (Russian Federation) | Рамелтеон M-II |
| nl-NL | Dutch (Netherlands) | ramelteon M-II |
| fr-BE | French (Belgium) | Ramelteon M-II |
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