LP101192-5
IL28B gene associated variant rs12979860
Active
Descriptions
The CC genotype is associated with a greater rate of sustained virological response than the TT or CT genotypes. Source: LOINC partner 1
The Interleukin-28b (IL28B) gene is located on chromosome 19q13.13 and encodes interferon-lambda-3 (IFN-lambda-3). IL28B belongs to the gene family of interleukins and interleukin receptors. A single nucleotide polymorphism (g.39738787C>T, rs12979860) located near the IL28B gene is known to alter hepatitis C treatment-induced viral clearance. It is associated with an approximately twofold change in response to pegylated interferon-alpha (PEG-IFN-alpha) and ribavirin (RBV) treatments, both among patients of European ancestry (p = 1.06 x 10e-25) and African-Americans (p = 2.06 x 10e-3). Studies indicate that the virus was eradicated in ~80% of patients with wildtype alleles (C;C) compared to only about 25% of those with homozygous alleles (T;T). Patient's with heterozygous alleles (C;T) had an intermediate response. For HCV genotypes other than type 1 (HCV-1), the usefulness of predicting response to therapy based on this SNP is unknown. Source: Regenstrief LOINC, PMID: 19684573
Basic Part Properties
- Part Display Name
- IL28B gene associated variant rs12979860
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2010-07-08
- Construct for LOINC Short Name
- IL28B rs12979860
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP101192-5
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | IL28B 基因相关变体 rs12979860 Synonyms: IL28B 基因相关突变体 rs12979860; |
| es-ES | Spanish (Spain) | variante (SNP) rs12979860 del gen IL28B |
| it-IT | Italian (Italy) | IL28B, gene associato a variante rs12979860 |
| tr-TR | Turkish (Turkey) | IL28B geni ile ilişkili varyant rs12979860 |
| ru-RU | Russian (Russian Federation) | IL28B ген ассоциированный вариант rs12979860 |
| nl-NL | Dutch (Netherlands) | IL28B-gen geassocieerde variant rs12979860 Synonyms: IL28B gen geassocieerde variant rs12979860 |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright