Version 2.78

Description

T cell receptor excision circles (TRECs) are formed as a byproduct of T cell receptor (TCR) generation in the thymus. Every T cell has a unique TCR, and formation of TCRs involves DNA rearrangement into different combinations of variable, diversity, and joining sequences. As these combinations are created, the remaining fragments of excised DNA form circular structures, or TRECs. The number of TRECs is proportional to T cell production, with low TREC numbers being an indicator of inadequate T cell production. In newborns, dried blood spot TREC analysis is used to screen for severe combined immunodeficiency as well as other disorders associated with low T cell counts, such as DiGeorge syndrome, trisomy 21, CHARGE syndrome, and congenital leukemia. PMID: 25937517 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
T-cell receptor excision circle
Part Type
Component (Describes the core component or analyte measured)
Created On
2010-11-23
Construct for LOINC Short Name
TREC

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP111251-7

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) T-细胞受体重排删除环
Synonyms: T-細胞受體重排刪除環;T-細胞受體切除環;T-细胞受体重排删除环;T-细胞受体重排切割环;T-cell receptor excision circle;TREC;T cell receptor rearrangement excision circle
es-ES Spanish (Spain) Círculos de escisión del receptor de células T
it-IT Italian (Italy) Linfocita T, circolo di escissione recettore
Synonyms: Circolo di escissione di recettore di linfocita T
tr-TR Turkish (Turkey) T-hücresi reseptörü excision circle
ru-RU Russian (Russian Federation) T-клеточного рецептора исключения круг
nl-NL Dutch (Netherlands) T-celreceptor excisiecirkel