Version 2.80

Descriptions

The AGXT (alanine-glyoxylate aminotransferase) gene provides instructions for making a liver-specific peroxisomal enzyme, alanine-glyoxylate aminotransferase (AGT). Mutations in the AGXT gene lead to deficient AGT enzyme activity and ultimately primary hyperoxaluira type 1 (PH1), an autosomal recessive disorder in which excessive oxalates are formed by the liver and excreted by the kidneys. Clinical symptoms included increased urinary oxalate, glycolate, and glycerate excreation, which lead to a wide spectrum of diseases ranging from renal failure in infancy to renal stones in late adulthood. Source: Regenstrief LOINC

The AGXT gene (alanine-glyoxylate aminotransferase) [HGNC Gene ID:341] is located on chromosome 2q37.3. This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008] [NCBI Gene ID:189] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Name
AGXT gene
Part Display Name
AGXT gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2011-11-01
Construct for LOINC Short Name
AGXT gene

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CodeSystem lookup
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) AGXT 基因
Synonyms: AGXT;血管紧张素原基因;angiotensinogen gene
tr-TR Turkish (Turkey) AGXT geni
it-IT Italian (Italy) AGXT, gene
Synonyms: Gene AGXT
ru-RU Russian (Russian Federation) AGXT ген
es-ES Spanish (Spain) Gen AGXT
nl-NL Dutch (Netherlands) AGXT-gen
Synonyms: AGXT gen
el-GR Greek (Greece) Γονίδιο AGXT
Synonyms: Γονίδιο AGXT