Version 2.76

Description

Hepatitis C virus (HCV) is a small (50 nm in size), enveloped, single-stranded, positive sense RNA virus in the genus hepacivirus, which is in the Flaviviridae family. More than 170 million people worldwide are affected by hepatitis C, and the majority of patients with acute hepatitis C develop chronic HCV infection, which can result in liver cirrhosis, hepatic failure or hepatocellular carcinoma. The HCV core protein is a highly basic, RNA-binding protein that forms the viral capsid. The E1 and E2 envelope glycoproteins are necessary for viral entry and fusion. Non-structural proteins include NS2, NS3, NS4A and 4B, and NS5A and 5B. The NS2-NS3 complex functions as a protease, and NS3 also has a helicase/NTPase domain. NS4A is a cofactor of NS3 protease activity. NS3-NS4A protease is one target of anti-HCV drugs. NS4B is a membrane anchor for the replication complex, and NS5A plays a role in regulating viral replication. NS5B is an RNA-dependent RNA polymerase. [NCBI Books: NBK1630] Source: Regenstrief LOINC, NCBI Books: NBK1630

Basic Part Properties

Part Display Name
Hepatitis C virus
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
HCV

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP14400-3
ConceptMap translate
https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP14400-3

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 丙型肝炎病毒
Synonyms: HCV;Hep C;丙型肝炎;丙肝;丙肝病毒;肝炎病毒 C 型
fr-CA French (Canada) Virus de l'hépatite C
et-EE Estonian (Estonia) C-hepatiidi viirus
es-ES Spanish (Spain) Virus Hepatitis C
it-IT Italian (Italy) Epatite C, virus
Synonyms: Virus dell''epatite C
el-GR Greek (Greece) Ιός Ηπατίτιδας C
tr-TR Turkish (Turkey) Hepatit C virüsü
ru-RU Russian (Russian Federation) Гепатита С вирус
nl-NL Dutch (Netherlands) Hepatitis C-virus
fr-BE French (Belgium) Virus de l'hépatite C
Synonyms: HCV
pl-PL Polish (Poland) Wirus zapalenia wątroby typu C