LP14490-4
Keratan sulfate
Active
Descriptions
A sulfated mucopolysaccharide initially isolated from bovine cornea. At least two types are known. Type I, found mostly in the cornea, contains D-galactose and D-glucosamine-6-O-sulfate as the repeating unit; type II, found in skeletal tissues, contains D-galactose and D-galactosamine-6-O-sulfate as the repeating unit. Source: National Library of Medicine, MeSH 2006
Keratan sulfate (KS) is one of the glycosaminoglycans found primarily in the cornea, nervous tissue, and bone. When the enzyme that breaks down KS is deficient or absent, KS accumulates in lysosomes which results in cell, tissue, and organ dysfunction. The lysosomal storage disorders are known as mucopolysaccharidoses (MPS) and can involve impaired enzymatic function that blocks the catabolism of any of the glycosaminoglycans, including dermatan sulfate, heparin sulfate, keratan sulfate, chondroitin sulfate, or hyaluronan. MPS due to the accumulation of any one or more glycosaminoglycans have many symptoms in common including a chronic or progressive course, multisystem involvement, organomegaly, dysostosis multiplex, abnormal facies, affected hearing, affected vision, affected airway, cardiovascular issues, profound mental retardation, and joint mobility difficulties. MPS can be diagnosed by testing for the deficient or absent enzyme. Enzyme replacement therapy is used to monitor treatment.[https://ommbid.mhmedical.com/content.aspx?bookid=971§ionid=62642135] Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Keratan sulfate
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Keratan Sulfate
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 硫酸角质素 |
| fr-CA | French (Canada) | Sulfate de kératane |
| et-EE | Estonian (Estonia) | Kerataansulfaat |
| es-ES | Spanish (Spain) | Queratán sulfato |
| it-IT | Italian (Italy) | Cheratan solfato |
| tr-TR | Turkish (Turkey) | Keratan sülfat |
| ru-RU | Russian (Russian Federation) | Кератансульфат |
| nl-NL | Dutch (Netherlands) | keratansulfaat |
| fr-BE | French (Belgium) | Sulfate de kératane |
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