LP14543-0
Cancer Ag 125
Active
Description
CA 125 is an antigenic determinant associated with a mucin-like glycoprotein, molecular weight exceeding 500,000 Daltons. This determinant is recognized by the murine monoclonal antibody OC 125, which reacts with over 80% of epithelial ovarian cancers. Elevated CA 125 levels have been reported in subjects with serous, endometrioid, clear cell, and undifferentiated ovarian carcinoma adenocarcinoma of the endometrium or fallopian tube, as well as some nongynocologic malignancies and certain nonmalignant conditions. Elevated levels also have been observed in pregnant women, most often during the first trimester. CA 125 levels may have significant value in monitoring ovarian carcinoma patients. A persistently rising CA 125 value may be associated with progressive malignant disease and poor therapeutic response. A declining CA 125 value is indicative of favorable prognosis and good response to treatment. CA 125 levels may help predict whether an invasive second-look procedure such as laparoscopy or laparotomy is required after treatment for epithelial ovarian cancer.
I.A. KOELMA, M. NAP, C.J. RODENBURG, G.J. FLEUREN (1987) The value of tumour marker CA 125 in surgical pathology
Histopathology 11 (3) , 287-294 doi:10.1111/j.1365-2559.1987.tb02633.
Source: Regenstrief Institute
Basic Part Properties
- Part Display Name
- Cancer Ag 125
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Cancer Ag125
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 癌抗原 125 Synonyms: CA 125; |
| fr-CA | French (Canada) | Ag carbohydraté 125 |
| et-EE | Estonian (Estonia) | Kasvajaantigeen CA 125 |
| es-ES | Spanish (Spain) | Ag de cáncer 125 |
| it-IT | Italian (Italy) | Cancro, Ag 125 Synonyms: Antigene 125 di cancro |
| el-GR | Greek (Greece) | Καρκινικό αντιγόνο 125 Synonyms: CA 125 |
| tr-TR | Turkish (Turkey) | Kanser Ag 125 |
| ru-RU | Russian (Russian Federation) | Раковый Аг 125 |
| nl-NL | Dutch (Netherlands) | CA125 Synonyms: kanker Ag 125 |
| fr-BE | French (Belgium) | Ag carbohydraté 125 Synonyms: Ca 125 |
| pl-PL | Polish (Poland) | CA 125 Ag Synonyms: Antygen CA 125 |
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