Version 2.77


CA 125 is an antigenic determinant associated with a mucin-like glycoprotein, molecular weight exceeding 500,000 Daltons. This determinant is recognized by the murine monoclonal antibody OC 125, which reacts with over 80% of epithelial ovarian cancers. Elevated CA 125 levels have been reported in subjects with serous, endometrioid, clear cell, and undifferentiated ovarian carcinoma adenocarcinoma of the endometrium or fallopian tube, as well as some nongynocologic malignancies and certain nonmalignant conditions. Elevated levels also have been observed in pregnant women, most often during the first trimester. CA 125 levels may have significant value in monitoring ovarian carcinoma patients. A persistently rising CA 125 value may be associated with progressive malignant disease and poor therapeutic response. A declining CA 125 value is indicative of favorable prognosis and good response to treatment. CA 125 levels may help predict whether an invasive second-look procedure such as laparoscopy or laparotomy is required after treatment for epithelial ovarian cancer.
I.A. KOELMA, M. NAP, C.J. RODENBURG, G.J. FLEUREN (1987) The value of tumour marker CA 125 in surgical pathology
Histopathology 11 (3) , 287-294 doi:10.1111/j.1365-2559.1987.tb02633. Source: Regenstrief Institute

Basic Part Properties

Part Display Name
Cancer Ag 125
Part Type
Component (Describes the core component or analyte measured)
Created On
Construct for LOINC Short Name
Cancer Ag125

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup$lookup?system=

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 癌抗原 125
Synonyms: CA 125;OC125;癌 Ag 125;癌抗原 125(Cancer Antigen 125,CA 125)
fr-CA French (Canada) Ag carbohydraté 125
et-EE Estonian (Estonia) Kasvajaantigeen CA 125
es-ES Spanish (Spain) Ag de cáncer 125
it-IT Italian (Italy) Cancro, Ag 125
Synonyms: Antigene 125 di cancro
el-GR Greek (Greece) Καρκινικό αντιγόνο 125
Synonyms: CA 125
tr-TR Turkish (Turkey) Kanser Ag 125
ru-RU Russian (Russian Federation) Раковый Аг 125
nl-NL Dutch (Netherlands) CA125
Synonyms: kanker Ag 125
fr-BE French (Belgium) Ag carbohydraté 125
Synonyms: Ca 125
pl-PL Polish (Poland) CA 125 Ag
Synonyms: Antygen CA 125