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Type-IV collagen is a type of collagen found primarily in the basal lamina. The type IV collagen C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, type-IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the overall arrangement more sloppy with kinks. These two features cause the collagen to form in a sheet, the form of the basal lamina.

The alpha 3 protein constituent of type-IV collagen is thought to be the antigen implicated in Goodpasture's syndrome, wherein the immune system attacks the basement membranes of the glomeruli and the alveoli.

Mutations to the genes coding for type-IV collagen lead to Alport syndrome. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, Type-IV collagen

Basic Part Properties

Part Display Name
Collagen type 4
Part Type
Component (Describes the core component or analyte measured)
Created On
Construct for LOINC Short Name

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 胶原 4 型
Synonyms: 4 型胶原;IV 型胶原;胶原 IV 型
fr-CA French (Canada) Collagène de type IV
et-EE Estonian (Estonia) Kollageeni tüüp 4
es-ES Spanish (Spain) Colageno tipo 4
it-IT Italian (Italy) Collagene tipo 4
tr-TR Turkish (Turkey) Kollajen tip 4
ru-RU Russian (Russian Federation) Коллаген тип 4
nl-NL Dutch (Netherlands) collageen type 4
fr-BE French (Belgium) Collagène de type IV