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One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil major basic protein is a 14-kDa cytotoxic peptide with a pI of 10.9. In addition to its direct cytotoxic effects, it stimulates the release of variety of INFLAMMATION MEDIATORS. Source: National Library of Medicine, MeSH 2006

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein), also known as PRG2, is a protein which in humans is encoded by the PRG2 gene.

PRG2 is a 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro. The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, activates neutrophils and alveolar macrophages, and is directly implicated in epithelial cell damage, exfoliation and bronchospasm in asthma. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, Wikipedia

Basic Part Properties

Part Display Name
Eosinophil major basic protein
Part Type
Component (Describes the core component or analyte measured)
Created On
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 嗜酸性粒细胞主要碱性蛋白
Synonyms: EMBP;嗜酸性粒细胞主要碱性蛋白(Eosinophil major basic protein,EMBP)
fr-CA French (Canada) Protéine basique majeure des éosinophiles
es-ES Spanish (Spain) Proteína mayor básica del eosinófilo
it-IT Italian (Italy) Eosinofili, proteina basica maggiore
Synonyms: Proteina basica maggiore (MBP) degli eosinofili
tr-TR Turkish (Turkey) Eozinofil major bazik protein
ru-RU Russian (Russian Federation) Эозинофилов большой основной протеин
nl-NL Dutch (Netherlands) eosinofiel major basic proteïne
fr-BE French (Belgium) Protéine basique majeure des éosinophiles
pl-PL Polish (Poland) Eozynofil, główne białko zasadowe
Synonyms: Główne białko zasadowe granulocytów kwasochłonnych