LP14687-5
Peanut agglutinin
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Descriptions
Lectin purified from peanuts (ARACHIS HYPOGAEA). It binds to poorly differentiated cells and terminally differentiated cells and is used in cell separation techniques. Source: National Library of Medicine, MeSH 2006
Peanut agglutinin (PNA) is plant lectin protein derived from the fruits of Arachis hypogaea. Peanut agglutinin may also be referred to as Arachis hypogaea lectin. Lectins recognise and bind particular sugar sequences in carbohydrates; peanut agglutinin binds the carbohydrate sequence Gal-β(1-3)-GalNAc. The name "peanut agglutinin" originates from its ability to stick together (agglutinate) cells, such as neuramidase-treated erythrocytes, which have glycoproteins or glycolipids on their surface which include the Gal-β(1-3)-GalNAc carbohydrate sequence.
Because peanut agglutinin specifically binds a particular carbohydrate sequence it finds use in a range of methods for cell biology and biochemistry. For example in PNA-affinity chromatography the binding specificity of peanut agglutinin is used to isolate glycosylated molecules which have the sugar sequence Gal-β(1-3)-GalNAc. Peanut agglutinin activity is inhibited by lactose and galactose which compete for the binding site.
Other uses include Potent anti-T cell activity, distinguishing between human lymphocyte subsets, tumour tissue determination for transitional mucosa malignancies, identification of mammalian-infective metacyclic promastigote Leishmania major parasites from other life cycle forms also found in the sandfly host.
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Source: Wikipedia, Wikipedia
Basic Part Properties
- Part Display Name
- Peanut agglutinin
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- PNA
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 花生凝集素 Synonyms: PNA; |
| fr-CA | French (Canada) | Agglutinine d'arachide |
| et-EE | Estonian (Estonia) | Maapähkli aglutiniin |
| es-ES | Spanish (Spain) | Aglutinina de cacahuete |
| it-IT | Italian (Italy) | Arachidi, agglutinina Synonyms: Agglutinina delle arachidi |
| tr-TR | Turkish (Turkey) | Yerfıstığı aglütinin |
| ru-RU | Russian (Russian Federation) | Арахиса агглютинин |
| nl-NL | Dutch (Netherlands) | pinda-agglutinine |
| fr-BE | French (Belgium) | Agglutinine d'arachide |
| pl-PL | Polish (Poland) | Aglutynina orzechów ziemnych Synonyms: Aglutynina zawarta w orzechach ziemnych |
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