LP14717-0
Doxepin
Active
Descriptions
Doxepin is a tricyclic antidepressant, known under many brand-names such as Aponal ®, the original preparation by Boehringer-Ingelheim, now part of the Roche group; Adapine ®, Sinquan ® and Sinequan ® (Pfizer Inc.). As doxepin hydrochloride it is the active ingredient in cream based preparations (Zonalon ® and Xepin ®) for the treatment of dermatological itch. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Doxepin (Wikipedia)
Doxepin is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors. Source: National Library of Medicine, MeSH 2006
Doxepin is indicated for the short-term (up to 8 days) topical treatment of moderate pruritus in adult patients with eczematous dermatitis. E.g., atopic dermatitis and lichen simplex chronicus. Once absorbed into the systemic circulation, doxepin undergoes hepatic metabolism that results in the conversion to the pharmacologically active metabolite, desmethyldoxepin. The parent compound and its metabolite also undergo glucuronidiation. Source: Regenstrief Institute
Basic Part Properties
- Part Display Name
- Doxepin
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Doxepin
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 多虑平 Synonyms: 凯舒; |
| fr-CA | French (Canada) | Doxépine |
| et-EE | Estonian (Estonia) | Doksepiin |
| es-ES | Spanish (Spain) | Doxepina |
| it-IT | Italian (Italy) | Doxepina |
| tr-TR | Turkish (Turkey) | Dokzepin |
| ru-RU | Russian (Russian Federation) | Доксепин |
| nl-NL | Dutch (Netherlands) | doxepine |
| fr-BE | French (Belgium) | Doxépine |
LOINC Copyright
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