LP14886-3
Lipoprotein (little a)
Active
Descriptions
Caution: this is not the same as alpha lipoprotein. Source: Regenstrief Institute
Increased levels of lipoprotein (a) are observed in patients with coronary artery disease, stroke, cerebrovascular and peripheral vascular disease and rarely in venous thrombosis. Substantial increases are observed in nephrotic syndrome and end-state renal disease. DecreasedlLipoprotein (a) levels may be seen in several rare disorders such as lecithin:cholesterol acyltranferase [LCAT] deficiency, lipoprotein lipase [LPL] deficiency, and liver disease). Levels in African Americans may be 2 to 3 times higher than in Caucasians and Asians whereas Native Americans and Mexican Americans have lower levels than in Caucasians and Asians. Information from Quest Diagnostics.
Lipoprotein (a) is an LDL cholesterol particle that is attached to a special protein called apo(a). In large part, a person's level of Lp(a) is genetically inherited. Elevated levels of Lp(a), higher than 20 mg/dL to 30 mg/dL in the blood are linked to a greated likelihood of atherosclerosis and heart attacks in both men and women. (The risk is even more significant if the Lp(a) cholesterol elevation is accompanied by high LDL/HDL ratios.) It accounts for only 15% of cholesterol so elevations can be missed in patients with normal cholesterols. Has 95% homology with plasminogen and possible interesting biologic relation to other phenomenon.
Source: Regenstrief Institute
Lipoprotein (a) is a modified form of LDL to which another glycoprotein, termed apolipoprotein (a), is covalently bound. It contributes to atherogenic risk by multiple mechanisms that include inhibition of fibrinolysis, increased cholesterol deposition in the arterial wall, and enhanced oxidation of LDL cholesterol. The evidence linking Lp(a) levels and the risk of coronary disease is strongest for middle aged white men. Higher Lp(a) levels have been consistently observed in white and Asian groups with vascular disease, but not in African Americans. Copyright Copyright © 2006 - 2008 ClinLab Navigator, LLC. Source: ClinLab Navigator, Apolipoprotein (a)
Basic Part Properties
- Part Display Name
- Lipoprotein a
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- LPa
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 脂蛋白 (a) Synonyms: Lp(a); |
| fr-CA | French (Canada) | Lipoprotéines (petite a) |
| et-EE | Estonian (Estonia) | Lipoproteiin a |
| es-ES | Spanish (Spain) | Lipoproteína a |
| it-IT | Italian (Italy) | Lipoproteina (a minuscola) Synonyms: Lipoproteina a |
| tr-TR | Turkish (Turkey) | Lipoprotein (küçük a) |
| ru-RU | Russian (Russian Federation) | Липопротеин (малое а) Synonyms: Липопротеин а |
| nl-NL | Dutch (Netherlands) | lipoproteïne (kleine a) |
| fr-BE | French (Belgium) | Lipoprotéines (petite a) Synonyms: Lpa |
| pl-PL | Polish (Poland) | Lipoproteina (a) |
LOINC Copyright
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