Version 2.77


Intercellular substance (ICS) antibodies are antibodies to any one of several intercellular antigens, including the desmosomal cadherins desmoglein 1 and 3, and desmocollin 1, 2, and 3, which play a role in cell to cell adhesion. ICS antibodies, especially of type IgG, are associated with paraneoplastic pemphigus (PNP), also known as paraneoplastic autoimmune multiorgan syndrome (PAMS), as well as with other forms of pemphigus including pemphigus foliaceus and pemphigus vulgaris. ICS antibody deposition has a characteristic web- or honeycomb-like fluorescent pattern. PMID: 31214197 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Intercellular substance
Part Type
Component (Describes the core component or analyte measured)
Created On
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 细胞间质
Synonyms: ICS;天泡疮;天疱疮;细胞间结构;细胞间结构(Intercellular structure,ICS);细胞间质(Intercellular Substance,ICS);胞间结构
fr-CA French (Canada) Matière intercellulaire
es-ES Spanish (Spain) Sustancia intercelular
it-IT Italian (Italy) Sostanza intercellulare
tr-TR Turkish (Turkey) Hücreler arası substans
ru-RU Russian (Russian Federation) Межклеточное вещество
nl-NL Dutch (Netherlands) intercellulaire substantie
fr-BE French (Belgium) Matière intercellulaire