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Pyridinoline is a fluorescent cross-linking compound of collagen fibers. Crosslinks in collagen and elastin are derived from lysyl and hydroxylysyl residues, a process catalyzed by lysyl oxidase. Fujimoto and colleagues first described the isolation and characterization of a fluorescent material in bovine achilles tendon collagen and termed it pyridinoline. It is reported to be present in collagen of bone and cartilage, but is absent in collagen of skin. It is not present in newly synthesized collagen and is formed from aldimine cross-links during maturation of collagen fibers.

Pyridinoline and deoxypyridinoline were found to be released into the blood during bone degradation and rapidly exereted in the urine. In a preliminary study, both these compounds were proposed as a marker for metastatic bone tumor in patients with prostate cancer. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, Wikipedia

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Tag Language Translation
zh-CN Chinese (China) 吡啶啉
Synonyms: 吡啶诺林;PYD;Pyr;吡啶醚;吡啶酚
fr-CA French (Canada) Pyridinoline
et-EE Estonian (Estonia) Püridinoliin
es-ES Spanish (Spain) Piridinolina
it-IT Italian (Italy) Piridinolina
tr-TR Turkish (Turkey) Piridinolin
ru-RU Russian (Russian Federation) Пиридинолин
nl-NL Dutch (Netherlands) pyridinoline
fr-BE French (Belgium) Pyridinoline