LP15216-2
LW
Active
Descriptions
The LW and D antigens are closely related. Rh+ red cells express LW more strongly than Rh negative cells. The early nomenclature tried to accommodate this observation by using a numerical system; eg. LW1, LW2, etc. but this changed following Sistonen's report of a new low frequency antigen called Ne^a which was found in ~5% of Finns. Because further work suggested that the Ne^a gene was allelic to LW, they were renamed LW^a and LW^b (Ne^a). Thus, the null phenotype for this system would be LW(a-b-) which is extremely rare and is the result of a partial gene deletion. A transient or acquired form of LW(a-b-) has been reported and these individuals are found because they produce a transient anti-LW. Some (but not all) examples have been associated with terminal illnesses such as Hodgkin's disease, leukemia, sarcomas or other malignancies. Source: Serum, Cells and Rare Fluid Exchange, LW
Although genetically independent of the Rh system, the Landsteiner Wiener (LW) blood group antigen system is part of the Rh protein cluster and is expressed more strongly on D positive cells. There are 2 antithetical alleles, LW^a and LW^b with 4 possible phenotypes: LW(a+b-), LW(a-b+), LW(a+b+), and LW(a-b-).(Schenkel-Brunner H. (2000) Landsteiner-Wiener System. In: Human Blood Groups. Springer, Vienna) LW^a has much higher prevalence than LW^b in most populations. Hemolytic disease of the newborn due to anti-LW is rare and mild when it does occur [https://en.wikipedia.org/wiki/ICAM4]. Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- LW
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- LW
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | LW Synonyms: Landsteiner-Wiener (LW); |
| fr-CA | French (Canada) | LW |
| et-EE | Estonian (Estonia) | LW |
| es-ES | Spanish (Spain) | Grupo sanguíneo LW |
| it-IT | Italian (Italy) | LW |
| tr-TR | Turkish (Turkey) | LW |
| ru-RU | Russian (Russian Federation) | LW |
| nl-NL | Dutch (Netherlands) | LW |
| fr-BE | French (Belgium) | LW |
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