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The renal juxtaglomerular apparatus generates renin, an enzyme that converts angiotensinogen to angiotensin I. Angiotensinogen, derived from the liver, is an alpha-2-globulin. The inactive angiotensin I is enzymatically converted to the active octapeptide angiotensin II, which is a potent vasopressor responsible for hypertension of renal orgin. Renin activity is elevated in renal vascular diseases and suppressed in primary hyperaldosteronism. Renin activity is affected by diuretics and low sodium stimulates activity. Source: Regenstrief Institute

Reference Information

Type Source Reference
Article Regenstrief Institute New Assays for Aldosterone, Renin, and Parathyroid Hormone. UW Department of Laboratory Medicine Renin laboratory mesurement

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 肾素
Synonyms: 肾活素;血管紧张素形成酶;血管紧张素形成酶(Angiotensin forming enzyme);血管紧张肽原酶;高血压蛋白原酶
fr-CA French (Canada) Rénine
et-EE Estonian (Estonia) Reniin
es-ES Spanish (Spain) Renina
it-IT Italian (Italy) Renina
el-GR Greek (Greece) Ρενίνη
tr-TR Turkish (Turkey) Renin
ru-RU Russian (Russian Federation) Ренин
nl-NL Dutch (Netherlands) renine
fr-BE French (Belgium) Rénine