LP15456-4
Cholecalciferol
Active
Descriptions
Derivative of 7-dehydroxycholesterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from ergocalciferol in having a single bond between C22 and C23 and lacking a methyl group at C24. Source: National Library of Medicine, MeSH 2006
Cholecalciferol, also known as Vit D3, is a fat-soluble prohormone. Vitamin D has many functions including the regulation of calcium and phosphorus levels in blood, the promotion of bone formation and mineralization, and aid to the immune system by supporting phagocyctosis, anti-tumor activity, and immunomodulatory functions. A deficiency of vitamin D can be due to many causes including inadequate dietary intake, insufficient sunlight, malabsorption problems, inability to convert vitamin D into its active metabolite, kidney or liver impairment and many others. Vitamin D occurs naturally only in fish. It is produced in the skin when UVB radiation from sunlight reacts with 7-dehydrocholesterol (a derivative of cholesterol) to form pre-vitamin D3. The pre-vitamin D3 isomerizes to Vitamin D and is then hydroxylated in the liver to 25-hydroxycholecalciferol. 25-hydroxycholecalciferol is in turn hydroxylated in the kidney into two dihydroxylated metabolites which are 1,25-dihydroxycholecalciferol (the active hormone) and 24R,25 (OH)2D3. Information from Wikipedia accessed 2008 08 20. Source: Regenstrief Institute
Basic Part Properties
- Part Display Name
- Cholecalciferol
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Vitamin D3
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 胆钙化醇 Synonyms: C27H43OH; |
| fr-CA | French (Canada) | Cholécalciférol |
| et-EE | Estonian (Estonia) | Kolekaltsiferool |
| es-ES | Spanish (Spain) | Colecalciferol |
| it-IT | Italian (Italy) | Colecalciferolo |
| tr-TR | Turkish (Turkey) | Kolekalsiferol |
| ru-RU | Russian (Russian Federation) | Холекальциферол |
| nl-NL | Dutch (Netherlands) | cholecalciferol |
| fr-BE | French (Belgium) | Cholécalciférol Synonyms: Vitamine D3 |
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