Version 2.77


A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC Source: National Library of Medicine, MeSH 2006

Chymopapain is a proteolytic enzyme with a molecular weight of 27 kDa. It is extracted from a fraction of non-crystallised latex from a tropical tree, Carica papaya. Since 1965 it has been used to treat herniated disks through chemonucleolysis. Chemonucleolysis is a medical procedure that involves the dissolving of the gelatinous cushioning material in an intervertebral disk by the injection of an enzyme such as Chymopapain. A typical product for chemonucleolysis is Chymodiactin.

Chymopapain is the major active component of Papain. Because they have the same antigenic determinants, Papain and Chymopapain exhibit cross-reactivity. Chymopapain is more soluble and has greater proteolytic activity than Papain.

Chymopapain may commonly induce symptoms of allergy, including anaphylaxis and anaphylactoid reactions, in sensitised individuals undergoing chemonucleolysis. Although it has not been clinically investigated, there is a possibility of subsequent allergy to foods containing Chymopapain or closely related Papain. Copyright Copyright © 2006 Phadia AB. Source: ImmunoCap, ImmunoCap

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Tag Language Translation
zh-CN Chinese (China) 木瓜凝乳蛋白酶
Synonyms: 糜木瓜酶
fr-CA French (Canada) Chymopapaïne
et-EE Estonian (Estonia) Kümopapaiin
es-ES Spanish (Spain) Quimopapaina
it-IT Italian (Italy) Chimopapaina
tr-TR Turkish (Turkey) Kimopapain
ru-RU Russian (Russian Federation) Химопапаин
nl-NL Dutch (Netherlands) chymopapaïne
fr-BE French (Belgium) Chymopapaïne