Version 2.78

Description

Dermatan sulfate is a derived disaccharide that accumulates in lysosomes, extracellular matrix, and body fluids of people with mucopolysaccharidoses (MPSs). MPSs are rare disorders caused by a deficiency of enzymes that break down glycosaminoglycans (GAGs). Symptoms of MPS vary due to which storage product accumulates and the level of enzymatic function or concentration that remains. Symptoms include musculoskeletal, airway, cardiac, and central nervous system disorders. Treatments include hematopoietic stem cell transplantation for the more critical forms of MPS and intravenous enzyme replacement therapy for the others. Treatment is most effective when it is initiated before irreversible tissue damage has occurred. Because MPS is so rare and the symptoms so variable, it is difficult to diagnose in its earliest stages. A solution to that problem is the development of newborn screening assays that can detect dermatan sulfate, though the levels in the dried blood spot samples do not appear to predict the severity of disease. The pattern of dermatan and heparan sulfate can help distinguish between the different MPSs. PMID: 23084433 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Dermatan sulfate
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
Dermatan Sulfate

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP15532-2
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 硫酸皮肤素
Synonyms: 硫酸软骨素 B;软骨素 B 硫酸酯
fr-CA French (Canada) Dermatane-sulfate
et-EE Estonian (Estonia) Dermataansulfaat
es-ES Spanish (Spain) Dermatan sulfato
it-IT Italian (Italy) Dermatan solfato
tr-TR Turkish (Turkey) Dermatan sülfat
ru-RU Russian (Russian Federation) Дерматан сульфат
Synonyms: Дерматансульфат
nl-NL Dutch (Netherlands) dermatansulfaat
fr-BE French (Belgium) Dermatane-sulfate