LP15560-3
Estrone
Active
Descriptions
Estrone (C 18 H 22 O 2), an estrogenic hormone secreted by the ovary, has a melting point of 254.5 degrees Celsius. It is one of three estrogens which also include estriol and estradiol. Estrone is the least prevalent of the three hormones, estradiol being often more prevalent in normal females whereas estriol is prevalent primarily during pregnancy. Estrone sulfate is important in health and disease beause of its conversion to estrone sulfate, a long-lived derivative of estrone. Estrone sulfate acts as a pool of estrone which can be converted as needed to the more active estradiol. Estrone is synthesized from androstenedione, a derivative of progesterone. The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring. This reaction is similar to the conversion of testosterone to estradiol. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Estrone (Wikipedia)
An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from androstenedione directly, or from testosterone via estradiol. In humans, it is produced primarily by the cyclic ovaries, the placenta, and the adipose tissue of men and postmenopausal women. Source: National Library of Medicine, MeSH 2006
Estrone has low biological activity compared with estridiol. In humans the major source of E1 is the extraglandular conversion of androstenedione secreted by the adrenal gland. In women the sequence of events during the menstrual cycle depends on the stimulation of the ovary by gonadotropins and feedback by the estrogens on the hypothalamus and pituitary. Under normal circumstances the amount of E1 generated is small and does not play a significant role in feedback, but under abnormal conditions [e.g. obesity] the amount may become sufficient to interfere with normal feedback mechanisms and produce disturbances of the ovarian cycle. In men, E1 levels may be helpful in the diagnosis of gynecomastia or the detection of estrogen-producing tumors. Source: Regenstrief Institute
Basic Part Properties
- Part Display Name
- Estrone
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Estrone
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 雌酮 Synonyms: E1; |
| fr-CA | French (Canada) | Oestrone |
| et-EE | Estonian (Estonia) | Östroon |
| es-ES | Spanish (Spain) | Estrona |
| it-IT | Italian (Italy) | Estrone |
| tr-TR | Turkish (Turkey) | Östron |
| ru-RU | Russian (Russian Federation) | Эстрон |
| nl-NL | Dutch (Netherlands) | oestron |
| fr-BE | French (Belgium) | Oestrone Synonyms: E1 |
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