LP15573-6
Fibronectin
Active
Description
Fibronectin is a high-molecular weight (~440kDa) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins. In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin and heparan sulfate proteoglycans (e.g. syndecans).
Fibronectin exists as a dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds. The fibronectin protein is produced from a single gene, but alternative splicing of its pre-mRNA leads to the creation of several isoforms.
Two types of fibronectin are present in vertebrates:
- soluble plasma fibronectin (formerly called "cold-insoluble globulin", or CIg) is a major protein component of blood plasma (300 μg/ml) and is produced in the liver by hepatocytes.
- insoluble cellular fibronectin is a major component of the extracellular matrix. It is secreted by various cells, primarily fibroblasts, as a soluble dimer and is then assembled into an insoluble matrix in a complex cell-mediated process.
Fibronectin plays a major role in cell adhesion, growth, migration and differentiation, and it is important for processes such as wound healing and embryonic development. Altered fibronectin expression, degradation, and organization has been associated with a number of pathologies, including cancer and fibrosis.
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Source: Wikipedia, Wikipedia
Basic Part Properties
- Part Display Name
- Fibronectin
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Fibronectin
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 纤维连接蛋白 Synonyms: FN; |
| fr-CA | French (Canada) | Fibronectine |
| et-EE | Estonian (Estonia) | Fibronektiin |
| es-ES | Spanish (Spain) | Fibronectina |
| it-IT | Italian (Italy) | Fibronectina |
| tr-TR | Turkish (Turkey) | Fibronektin |
| ru-RU | Russian (Russian Federation) | Фибронектин |
| nl-NL | Dutch (Netherlands) | fibronectine |
| fr-BE | French (Belgium) | Fibronectine |
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