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4-Hydroxyproline, or hydroxyproline (C 5 H 9 O 3 N), is an uncommon amino acid, abbreviated as HYP. Hydroxyproline differs from proline by the presence of a hydroxyl (OH) group attached to the C (gamma) atom.

Proline hydroxylation requires ascorbic acid (vitamin C). The most obvious, first effects (gingival and hair problems) of absence of ascorbic acid in humans come from the resulting defect in hydroxylation of proline residues of collagen, with reduced stability of the collagen molecule, causing scurvy.
Increased serum and urine levels of hydroxyproline have also been demonstrated in Paget's disease. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, Hydroxyproline (Wikipedia)

A hydroxylated form of the amino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation. Source: National Library of Medicine, MeSH 2006

Hydroxyproline is a hydrophilic amino acid with uncharged polar groups and is a major component of collagen. Increased with hydroxyprolinemia and iminoglycinuria. Decreased with chronic Vitamin C deficiency. (Information from ARUP Laboratories 9/14/06) Source: Regenstrief Institute

Basic Part Properties

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Component (Describes the core component or analyte measured)
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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 羟基脯氨酸
Synonyms: Hyp;OH-脯氨酸;羟脯氨酸
fr-CA French (Canada) Hydroxyproline
et-EE Estonian (Estonia) Hüdroksüproliin
es-ES Spanish (Spain) Hidroxiprolina
it-IT Italian (Italy) Idrossiprolina
tr-TR Turkish (Turkey) Hidroksiprolin
ru-RU Russian (Russian Federation) Гидроксипролин
nl-NL Dutch (Netherlands) hydroxyproline
fr-BE French (Belgium) Hydroxyproline
Synonyms: OH-Proline