LP15673-4
Intrinsic factor
Active
Descriptions
Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 later on in the small intestine. Upon entry into the stomach, vitamin B12 becomes bound to one of two B12 binding proteins present in gastric juice. In the less acidic environment of the small intestine, these proteins dissociate from the vitamin, enabling it to bind to intrinsic factor and enter the portal circulation through a receptor in the ileal mucosa specific for the B12 -intrinsic factor complex. In pernicious anemia, an autoimmune disease, autoantibodies directed against intrinsic factor or parietal cells themselves lead to an intrinsic factor deficiency, malabsorption of vitamin B12, and subsequent megaloblastic anemia. Atrophic gastritis can also cause intrinsic factor deficiency and anemia through damage to the parietal cells of the stomach wall. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, intrinsic factor (Wikipedia)
A glycoprotein secreted by the cells of the gastric glands that is required for the absorption of VITAMIN B 12. Deficiency of intrinsic factor results in ANEMIA, PERNICIOUS. Source: National Library of Medicine, MeSH 2006
Basic Part Properties
- Part Display Name
- Intrinsic factor
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- IF
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 内因子 Synonyms: IF; |
| fr-CA | French (Canada) | Facteur intrinsèque |
| et-EE | Estonian (Estonia) | Sisemine faktor |
| es-ES | Spanish (Spain) | Factor intrínseco |
| it-IT | Italian (Italy) | Fattore intrinseco |
| tr-TR | Turkish (Turkey) | İntrinsik faktör |
| ru-RU | Russian (Russian Federation) | Внутренний фактор |
| nl-NL | Dutch (Netherlands) | intrinsieke factor |
| fr-BE | French (Belgium) | Facteur intrinsèque Synonyms: FI |
| pl-PL | Polish (Poland) | Czynnik wewnętrzny |
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