LP157423-7

CYP1A2 gene

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Description

The CYP1A2 gene (cytochrome P450, family 1, subfamily A, polypeptide 2) [HGNC Gene ID:2596] is located on chromosome 15q24.1. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1544] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Name

CYP1A2 gene

Part Display Name

CYP1A2 gene

Part Type

Component (Describes the core component or analyte measured)

Created On

2012-09-21

Construct for LOINC Short Name

CYP1A2

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