LP157474-0
WT1 gene exon 1+2 transcript
Active
Description
WT1 gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an important role in cell growth and differentiation. Initially isolated as the gene responsible for Wilms' tumor, it is implicated in several cancers. WT1 is expressed at high levels in most acute myeloid leukemias, AML (and in ALL too), making it a tumor marker for leukemic blasts. It is also expressed at high levels in solid tumors. The WT1 gene expression is used as a specific molecular marker to improve diagnosis, prognosis and follow-up of adult acute myeloid leukemia (AML) patients. Early decreased expression of WT1 copy number in peripheral blood predicts better outcome for AML patients. Regarding mutations, multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. Authors of PMID: 7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- WT1 gene exon 1+2 transcript
- Part Display Name
- WT1 gene exon 1+2 transcript
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2012-09-26
- Construct for LOINC Short Name
- WT1 ex 1+2
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP157474-0
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | WT1 基因外显子 1+2 转录物 Synonyms: WT1 基因外显子 1+2 转录物（转录本、 |
| es-ES | Spanish (Spain) | Transcrito del gen WT1 exón 1+2 |
| it-IT | Italian (Italy) | WT1, gene, esoni 1+2 trascritti Synonyms: Esoni 1+2 trascritti del gene WT1 |
| tr-TR | Turkish (Turkey) | WT1 geni ekzon 1+2 transkript |
| ru-RU | Russian (Russian Federation) | WT1 ген экзон 1+2 транскрипт |
| nl-NL | Dutch (Netherlands) | WT1-gen exon 1+2 transcript |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://