LP157496-3
t(4;14)(p16;q32)(FGFR3,IGH)
Active
Description
The t(4;14)(p16;q32)(FGFR3,IGH) is detected by FISH and PCR methods, but poorly analyzed by conventional cytogenetic methods (e.g. karyotyping). The breakpoints on chromosome 4 occur within a 113-kb gene cluster region involving the fibroblast growth factor receptor 3 (FGFR3) gene. The fusion results in overexpression and activation of FGFR3, which causes oncogenic signal enhancing cell proliferation and survival. The t(4;14) translocation provides important prognostic information in patients with plasma cell myeloma. It is often associated with poor survival and poor response to chemotherapy. Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- t(4;14)(p16;q32)(FGFR3,IGH)
- Part Display Name
- t(4;14)(p16;q32)(FGFR3,IGH)
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2012-10-01
- Construct for LOINC Short Name
- t(4;14)(FGFR3,IGH)
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | t(4; Synonyms: 易位(4; |
| es-ES | Spanish (Spain) | t(4; |
| it-IT | Italian (Italy) | t(4,14)(p16,q32)(FGFR3,IGH) |
| tr-TR | Turkish (Turkey) | t(4; |
| ru-RU | Russian (Russian Federation) | t(4; |
| nl-NL | Dutch (Netherlands) | t(4; |
| fr-CA | French (Canada) | t(4; |
| fr-FR | French (France) | t(4; |
| pl-PL | Polish (Poland) | t (4; Synonyms: Translokacja (4; |
| el-GR | Greek (Greece) | t(4; Synonyms: t(4; |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://