Version 2.80

Description

The t(4;14)(p16;q32)(FGFR3,IGH) is detected by FISH and PCR methods, but poorly analyzed by conventional cytogenetic methods (e.g. karyotyping). The breakpoints on chromosome 4 occur within a 113-kb gene cluster region involving the fibroblast growth factor receptor 3 (FGFR3) gene. The fusion results in overexpression and activation of FGFR3, which causes oncogenic signal enhancing cell proliferation and survival. The t(4;14) translocation provides important prognostic information in patients with plasma cell myeloma. It is often associated with poor survival and poor response to chemotherapy. Source: Regenstrief LOINC

Basic Part Properties

Part Name
t(4;14)(p16;q32)(FGFR3,IGH)
Part Display Name
t(4;14)(p16;q32)(FGFR3,IGH)
Part Type
Component (Describes the core component or analyte measured)
Created On
2012-10-01
Construct for LOINC Short Name
t(4;14)(FGFR3,IGH)

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP157496-3

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) t(4;14)(p16;q32)(FGFR3,IGH)
Synonyms: 易位(4;14)(p16;q32)(FGFR3,IGH)
ru-RU Russian (Russian Federation) t(4;14)(p16;q32)(FGFR3,IGH)
es-ES Spanish (Spain) t(4;14)(p16;q32)(FGFR3,IGH)
it-IT Italian (Italy) t(4;14)(p16;q32)(FGFR3,IGH)
tr-TR Turkish (Turkey) t(4;14)(p16;q32)(FGFR3,IGH)
nl-NL Dutch (Netherlands) t(4;14)(p16;q32)(FGFR3,IGH)
fr-CA French (Canada) t(4;14)(p16;q32)(FGFR3,IGH)
pl-PL Polish (Poland) t (4; 14) (p16; q32) (FGFR3,IGH)
Synonyms: Translokacja (4; 14) (p16; q32) (FGFR3,IGH)
el-GR Greek (Greece) t(4;14)(p16;q32)(FGFR3,IGH)
Synonyms: t(4;14)(p16;q32)(FGFR3,IGH)