LP15798-9
Phosphatidylglycerol
Active
Description
Phosphatidylglycerol is a glycerophospholipid found in pulmonary surfactant.
The general structure of phosphatidylglycerol consists of a L-glycerol 3-phosphate backbone ester-bonded to either saturated or unsaturated fatty acids on carbons 1 and 2. The head group substituent glycerol is bonded through a phosphomonoester. It is the precursor of surfactant and its presence in the amniotic fluid of the newborn indicates fetal lung maturity.
Approximately 98% of alveolar wall surface area is due to the presence of type I cells, with type II cells producing pulmonary surfactant covering around 2% of the alveolar walls. Once surfactant is secreted by the type II cells, it must be spread over the remaining type I cellular surface area. Phosphatidylglycerol is thought to be important in spreading of surfactant over the Type I cellular surface area. The major surfactant deficiency in premature infants is associated with the lack of phosphatidylglycerol, even though it comprises less than 5% of pulmonary surfactant phospholipids.
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Source: Wikipedia, Phosphatidylglycerol
Basic Part Properties
- Part Display Name
- Phosphatidylglycerol
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- PG
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 磷脂酰甘油 Synonyms: PG; |
| fr-CA | French (Canada) | Phosphatidylglycérol |
| et-EE | Estonian (Estonia) | Fosfaatidüülglütserool |
| es-ES | Spanish (Spain) | Fosfatidilglicerol |
| it-IT | Italian (Italy) | Fosfatidilglicerolo |
| tr-TR | Turkish (Turkey) | Fosfatidilgliserol |
| ru-RU | Russian (Russian Federation) | Фосфатидилглицерол |
| nl-NL | Dutch (Netherlands) | fosfatidylglycerol |
| fr-BE | French (Belgium) | Phosphatidylglycérol |
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