LP15821-9
Propionyl CO-A carboxylase
Active
Description
Propionyl-CoA carboxylase catalyses the carboxylation reaction of propionyl CoA. The product of the reaction is (S)-methylmalonyl CoA. Propionyl CoA is the end product of metabolism of odd-chain fatty acids, and is also a metabolite of most methyl-branched fatty acids. It is also the main metabolite of valine, and together with acetyl-CoA, is a metabolite of isoleucine, as well as a methionine metabolite. Propionyl-CoA is thus of great importance as a glucose precursor. (S)-Methylmalonyl-CoA is not directly utilizable by animals; it is acted on by a racemase to give (R)-methylmalonyl-CoA. The latter is converted by methylmalonyl-CoA mutase (one of a very few Vitamin B12 dependent enzymes) to give succinyl-CoA. The latter is converted to oxaloacetate and then malate in the Krebs cycle. Export of malate into the cytosol leads to formation of oxaloacetate, phosphoenol pyruvate, and other gluconeogenic intermediates.
A deficiency is associated with propionic acidemia.
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Source: Wikipedia, Wikipedia
Basic Part Properties
- Part Display Name
- Propionyl CoA Carboxylase
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- PCCA
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 丙酰 CoA 羧化酶 Synonyms: PCC; |
| fr-CA | French (Canada) | Propionyl-CoA carboxylase |
| et-EE | Estonian (Estonia) | Propionüül CoA karboksülaas |
| es-ES | Spanish (Spain) | Propionil CoA carboxilasa |
| it-IT | Italian (Italy) | Propionil CO-A carbossilasi Synonyms: Propionil CoA Carbossilasi |
| tr-TR | Turkish (Turkey) | Propiyonil KoA karboksilaz |
| ru-RU | Russian (Russian Federation) | Пропионил CoA карбоксилаза Synonyms: Пропионил КоА карбоксилаза |
| nl-NL | Dutch (Netherlands) | propionyl CO-A carboxylase |
| fr-BE | French (Belgium) | Propionyl-CoA carboxylase |
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