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Sarcosine is the N-methyl derivative of glycine. It is a natural amino acid found in muscles and other body tissues. In the laboratory, it may be synthesized from chloroacetic acid and methylamine. Sarcosine is found naturally as an intermediate in the metabolism of choline to glycine. Sarcosine is sweet to the taste and dissolves in water. It is used in manufacturing biodegradable surfactants and toothpastes as well as in other applications. Sarcosine is ubiquitous in biological materials and is present in such foods as egg yolks, turkey, ham, vegetables, legumes, etc. Sarcosine is reported to be formed from dietary intake of choline and from the metabolism of methionine and is rapidly degraded to glycine, which, in addition to its importance as a constituent of protein, plays a significant role in various physiological processes as a prime metabolic source of components of living cells such as glutathione, creatine, purines and serine.

Sarcosinemia can result from severe folate deficiency because of the folate requirement for the conversion of sarcosine to glycine. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, Sarcosine (Wikipedia)

An amino acid intermediate in the metabolism of choline. Source: National Library of Medicine, MeSH 2006

High levels of sarcosine may occur as a result of vitamin B2 insufficiency as vitamin B2 is required to metabolize sarcosine. Information from Metamatrix Clinical Laboratory 2006 12 01. Source: Regenstrief Institute

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Tag Language Translation
zh-CN Chinese (China) 肌氨酸
Synonyms: N甲基甘氨酸;N-甲基甘氨酸
fr-CA French (Canada) Sarcosine
et-EE Estonian (Estonia) Sarkosiin
es-ES Spanish (Spain) Sarcosina
it-IT Italian (Italy) Sarcosina
tr-TR Turkish (Turkey) Sarkozin
ru-RU Russian (Russian Federation) Саркозин
nl-NL Dutch (Netherlands) sarcosine
fr-BE French (Belgium) Sarcosine