LP15884-7
Tetrahydrodeoxycortisol
Active
Description
Tetrahydrodeoxycortisol (THS) is a mineralocorticoid the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approximately 5% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4%) and the T-allele of the -344 C/T polymorphism of CYP11B2 is more strongly associated with higher THS levels than the C-allele. PMID: 16984984, PMID: 15522937, PMID: 15272911. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Tetrahydrodeoxycortisol
Basic Part Properties
- Part Display Name
- Tetrahydrodeoxycortisol
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- TH-DC
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 四氢脱氧皮质醇 Synonyms: TH-DC; |
| et-EE | Estonian (Estonia) | Tetrahüdrodeoksükortisool |
| es-ES | Spanish (Spain) | Tetrahidrodesoxicortisol |
| it-IT | Italian (Italy) | Tetraidrodeossicortisolo |
| tr-TR | Turkish (Turkey) | Tetrahidrodeoksikortizol |
| ru-RU | Russian (Russian Federation) | Тетрагидродеоксикортизол Synonyms: Тетрагидродезоксикортизол |
| nl-NL | Dutch (Netherlands) | tetrahydrodeoxycortisol |
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